Proteolysis‐targeting chimeras in drug development: A safety perspective
Moreau, Kevin, Coen, Muireann, Zhang, Andrew X., Pachl, Fiona, Castaldi, M. Paola, Dahl, Goran, Boyd, Helen, Scott, Clay, Newham, Pete
Published in British journal of pharmacology (01.04.2020)
Published in British journal of pharmacology (01.04.2020)
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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex
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Published in Cell chemical biology (16.01.2020)
Published in Cell chemical biology (16.01.2020)
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Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Wrobel, Lidia, Hill, Sandra M., Djajadikerta, Alvin, Fernandez-Estevez, Marian, Karabiyik, Cansu, Ashkenazi, Avraham, Barratt, Victoria J., Stamatakou, Eleanna, Gunnarsson, Anders, Rasmusson, Timothy, Miele, Eric W., Beaton, Nigel, Bruderer, Roland, Feng, Yuehan, Reiter, Lukas, Castaldi, M. Paola, Jarvis, Rebecca, Tan, Keith, Bürli, Roland W., Rubinsztein, David C.
Published in Nature communications (16.07.2022)
Published in Nature communications (16.07.2022)
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CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins
Kawatkar, Aarti, Schefter, Michelle, Hermansson, Nils-Olov, Snijder, Arjan, Dekker, Niek, Brown, Dean G, Lundbäck, Thomas, Zhang, Andrew X, Castaldi, M. Paola
Published in ACS chemical biology (20.09.2019)
Published in ACS chemical biology (20.09.2019)
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Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers
Koundinya, Malvika, Sudhalter, Judith, Courjaud, Albane, Lionne, Bruno, Touyer, Gaetan, Bonnet, Luc, Menguy, Isabelle, Schreiber, Isabelle, Perrault, Christelle, Vougier, Stephanie, Benhamou, Brigitte, Zhang, Bailin, He, Timothy, Gao, Qiang, Gee, Patricia, Simard, Daniel, Castaldi, M. Paola, Tomlinson, Ronald, Reiling, Stephan, Barrague, Matthieu, Newcombe, Richard, Cao, Hui, Wang, Yanjun, Sun, Fangxian, Murtie, Joshua, Munson, Mark, Yang, Eric, Harper, David, Bouaboula, Monsif, Pollard, Jack, Grepin, Claudine, Garcia-Echeverria, Carlos, Cheng, Hong, Adrian, Francisco, Winter, Christopher, Licht, Stuart, Cornella-Taracido, Ivan, Arrebola, Rosalia, Morris, Aaron
Published in Cell chemical biology (21.06.2018)
Published in Cell chemical biology (21.06.2018)
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Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
Doshi, Aatman S, Cantin, Susan, Hernandez, Marylens, Srinivasan, Srimathi, Tentarelli, Sharon, Griffin, Matthew, Wang, Yanjun, Pop-Damkov, Petar, Prickett, Laura B, Kankkonen, Cecilia, Shen, Minhui, Martin, Maryann San, Wu, Song, Castaldi, M Paola, Ghadially, Hormas, Varnes, Jeffrey, Gales, Sonya, Henry, David, Hoover, Clare, Mele, Deanna A, Simpson, Iain, Gangl, Eric T, Mlynarski, Scott N, Finlay, M Raymond V, Drew, Lisa, Fawell, Stephen E, Shao, Wenlin, Schuller, Alwin G
Published in Molecular cancer therapeutics (04.05.2023)
Published in Molecular cancer therapeutics (04.05.2023)
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Robotic-Assisted Surgery Training (RAST): Assessment of Surgeon Console Ergonomic Skills
Castaldi, M.T., Palmer, M., Con, J., Bergamaschi, R.
Published in Journal of surgical education (01.11.2023)
Published in Journal of surgical education (01.11.2023)
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Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA
Hermann, Thomas, Parsons, Jerod, Castaldi, M Paola, Dutta, Sanjay, Dibrov, Sergey M, Wyles, David L
Published in Nature chemical biology (01.11.2009)
Published in Nature chemical biology (01.11.2009)
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Development of a Novel B‑Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6
McCoull, William, Cheung, Tony, Anderson, Erica, Barton, Peter, Burgess, Jonathan, Byth, Kate, Cao, Qing, Castaldi, M. Paola, Chen, Huawei, Chiarparin, Elisabetta, Carbajo, Rodrigo J, Code, Erin, Cowan, Suzanna, Davey, Paul R, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gao, Ning, Hargreaves, David, Howard, Martin R, Hu, Jun, Kawatkar, Aarti, Kemmitt, Paul D, Leo, Elisabetta, Molina, Daniel M, O’Connell, Nichole, Petteruti, Philip, Rasmusson, Timothy, Raubo, Piotr, Rawlins, Philip B, Ricchiuto, Piero, Robb, Graeme R, Schenone, Monica, Waring, Michael J, Zinda, Michael, Fawell, Stephen, Wilson, David M
Published in ACS chemical biology (16.11.2018)
Published in ACS chemical biology (16.11.2018)
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Predictive factors for the development of surgical site infection in adults undergoing initial open inguinal hernia repair
Sereysky, J., Parsikia, A., Stone, M. E., Castaldi, M., McNelis, J.
Published in Hernia : the journal of hernias and abdominal wall surgery (01.02.2020)
Published in Hernia : the journal of hernias and abdominal wall surgery (01.02.2020)
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Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS): A Multiplexed Microarray Platform for Targeted Proteomics
Hamza, Ghaith M, Bergo, Vladislav B, Mamaev, Sergey, Wojchowski, Don M, Toran, Paul, Worsfold, Camilla R, Castaldi, M Paola, Silva, Jeffrey C
Published in International journal of molecular sciences (16.03.2020)
Published in International journal of molecular sciences (16.03.2020)
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Genomic Discovery and Structure–Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors
Davison, Jack R., Hadjithomas, Michalis, Romeril, Stuart P., Choi, Yoon Jong, Bentley, Keith W., Biggins, John B., Chacko, Nadia, Castaldi, M. Paola, Chan, Lawrence K., Cumming, Jared N., Downes, Thomas D., Eisenhauer, Eric L., Fei, Fan, Fontaine, Benjamin M., Endalur Gopinarayanan, Venkatesh, Gurnani, Srishti, Hecht, Audrey, Hosford, Christopher J., Ibrahim, Ashraf, Jagels, Annika, Joubran, Camil, Kim, Ji-Nu, Lisher, John P., Liu, Daniel D., Lyles, James T., Mannara, Matteo N., Murray, Gordon J., Musial, Emilia, Niu, Mengyao, Olivares-Amaya, Roberto, Percuoco, Marielle, Saalau, Susanne, Sharpe, Kristen, Sheahan, Anjali V., Thevakumaran, Neroshan, Thompson, James E., Thompson, Dawn A., Wiest, Aric, Wyka, Stephen A., Yano, Jason, Verdine, Gregory L.
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit
Kawatkar, Aarti, Clark, Roger A., Hopcroft, Lorna, Roaquin, Debora Ann, Tomlinson, Ronald, Zuhl, Andrea M., Lamont, Gillian M., Kettle, Jason G., Critchlow, Susan E., Castaldi, M. Paola, Goldberg, Frederick W., Zhang, Andrew X.
Published in ACS chemical biology (17.02.2023)
Published in ACS chemical biology (17.02.2023)
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C3 Symmetry: Molecular Design Inspired by Nature
Gibson, Susan E., Castaldi, M. Paola
Published in Angewandte Chemie International Edition (17.07.2006)
Published in Angewandte Chemie International Edition (17.07.2006)
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Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods
Hendricks, J. Adam, Beaton, Nigel, Chernobrovkin, Alexey, Miele, Eric, Hamza, Ghaith M, Ricchiuto, Piero, Tomlinson, Ronald C, Friman, Tomas, Borenstain, Cassandra, Barlaam, Bernard, Hande, Sudhir, Lamb, Michelle L, De Savi, Chris, Davies, Rick, Main, Martin, Hellner, Joakim, Beeler, Kristina, Feng, Yuehan, Bruderer, Roland, Reiter, Lukas, Molina, Daniel Martinez, Castaldi, M. Paola
Published in ACS chemical biology (21.01.2022)
Published in ACS chemical biology (21.01.2022)
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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors
Stefaniak, Jakub, Lewis, Andrew M, Conole, Daniel, Galan, Sébastien R. G, Bataille, Carole J. R, Wynne, Graham M, Castaldi, M. Paola, Lundbäck, Thomas, Russell, Angela J, Huber, Kilian V. M
Published in ACS chemical biology (19.10.2018)
Published in ACS chemical biology (19.10.2018)
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A new spontaneous pupillary oscillation-based verification system
Villalobos-Castaldi, Fabiola M., Suaste-Gómez, Ernesto
Published in Expert systems with applications (01.10.2013)
Published in Expert systems with applications (01.10.2013)
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