High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines
Li, Yilai, Cash, Jennifer N., Tesmer, John J.G., Cianfrocco, Michael A.
Published in Structure (London) (07.07.2020)
Published in Structure (London) (07.07.2020)
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Journal Article
Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma
Lu, Tsan-Wen, Aoto, Phillip C, Weng, Jui-Hung, Nielsen, Cole, Cash, Jennifer N, Hall, James, Zhang, Ping, Simon, Sanford M, Cianfrocco, Michael A, Taylor, Susan S
Published in PLoS biology (01.12.2020)
Published in PLoS biology (01.12.2020)
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Journal Article
Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold
Cash, Jennifer N, Urata, Sarah, Li, Sheng, Ravala, Sandeep K, Avramova, Larisa V, Shost, Michael D, Gutkind, J Silvio, Tesmer, John J G, Cianfrocco, Michael A
Published in Science advances (16.10.2019)
Published in Science advances (16.10.2019)
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Journal Article
New insights into regulation of P-Rex1 autoinhibition
Ravala, Sandeep Kaur, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Cash, Jennifer N, Tesmer, John J G
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
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Journal Article
Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1
Bandekar, Sumit J., Chen, Chun-Liang, Ravala, Sandeep K., Cash, Jennifer N., Avramova, Larisa V., Zhalnina, Mariya V., Gutkind, J. Silvio, Li, Sheng, Tesmer, John J.G.
Published in The Journal of biological chemistry (01.08.2022)
Published in The Journal of biological chemistry (01.08.2022)
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Journal Article
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding
Ravala, Sandeep K., Hopkins, Jesse B., Plescia, Caroline B., Allgood, Samantha R., Kane, Madison A., Cash, Jennifer N., Stahelin, Robert V., Tesmer, John J.G.
Published in The Journal of biological chemistry (04.09.2020)
Published in The Journal of biological chemistry (04.09.2020)
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Journal Article
Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils
Cash, Jennifer N., Chandan, Naincy R., Hsu, Alan Y., Sharma, Prateek V., Deng, Qing, Smrcka, Alan V., Tesmer, John J.G.
Published in Molecular pharmacology (01.03.2020)
Published in Molecular pharmacology (01.03.2020)
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Journal Article
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4
Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG
Published in eLife (31.07.2024)
Published in eLife (31.07.2024)
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Journal Article
Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding
Cash, Jennifer N, Angerman, Elizabeth B, Kattamuri, Chandramohan, Nolan, Kristof, Zhao, Huaying, Sidis, Yisrael, Keutmann, Henry T, Thompson, Thomas B
Published in The Journal of biological chemistry (06.01.2012)
Published in The Journal of biological chemistry (06.01.2012)
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Journal Article
Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP 3 )-Dependent Rac Exchanger 1 (P-Rex1) PIP 3 -Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils
Cash, Jennifer N, Chandan, Naincy R, Hsu, Alan Y, Sharma, Prateek V, Deng, Qing, Smrcka, Alan V, Tesmer, John J G
Published in Molecular pharmacology (01.03.2020)
Published in Molecular pharmacology (01.03.2020)
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Journal Article
Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A
Cash, Jennifer N, Angerman, Elizabeth B, Kirby, R Jason, Merck, Lisa, Seibel, William L, Wortman, Matthew D, Papoian, Ruben, Nelson, Sandra, Thompson, Thomas B
Published in Journal of biomolecular screening (01.08.2013)
Published in Journal of biomolecular screening (01.08.2013)
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Journal Article
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4
Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG
Published in eLife (31.07.2024)
Published in eLife (31.07.2024)
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Journal Article
Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4
Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John J G
Published in eLife (31.07.2024)
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Published in eLife (31.07.2024)
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