Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle
Eliasof, Scott, Lazarus, Douglas, Peters, Christian G., Case, Roy I., Cole, Roderic O., Hwang, Jungyeon, Schluep, Thomas, Chao, Joseph, Lin, James, Yen, Yun, Han, Han, Wiley, Devin T., Zuckerman, Jonathan E., Davis, Mark E.
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2013)
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Discovery of a Novel Cabazitaxel Nanoparticle–Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β‑Cyclodextrin–PEG Copolymer Based Delivery Platform
Metcalf, Chester A, Svenson, Sonke, Hwang, Jungyeon, Tripathi, Snehlata, Gangal, Geeti, Kabir, Sujan, Lazarus, Douglas, Cole, Roderic, Sweryda-Krawiec, Beata, Shum, Pochi, Brown, Donna, Case, Roy I, van der Poll, Derek, Rohde, Ellen, Harlfinger, Stephanie, Teng, Chi-Hse, Eliasof, Scott
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Journal Article
Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical
Svenson, Sonke, Case, Roy I, Cole, Roderick O, Hwang, Jungyeon, Kabir, Sujan R, Lazarus, Douglas, Lim Soo, Patrick, Ng, Pei-Sze, Peters, Christian, Shum, Pochi, Sweryda-Krawiec, Beata, Tripathi, Snehlata, van der Poll, Derek, Eliasof, Scott
Published in Molecular pharmaceutics (07.03.2016)
Published in Molecular pharmaceutics (07.03.2016)
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Abstract 5135: Sustained and controlled in vivo therapeutic levels of drug payloads in tumors using two separate drug combination platforms: Antibody nanoparticle-drug conjugates and multi-drug nanoparticle-drug conjugates, with the potential for improved drug combinability and anticancer effects
Metcalf, Chester A., Poll, Derek van der, Zhao, Liang, Case, Roy I., Lazarus, Doug, Brown, Donna, Halo, Tiffany, Jayaraman, Lata, Peters, Christian, Rohde, Ellen, Eliasof, Scott
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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