Once‐daily oral small‐molecule glucagon‐like peptide‐1 receptor agonist lotiglipron (PF‐07081532) for type 2 diabetes and obesity: Two randomized, placebo‐controlled, multiple‐ascending‐dose Phase 1 studies
Buckeridge, Clare, Tsamandouras, Nikolaos, Carvajal‐Gonzalez, Santos, Brown, Lisa S., Hernandez‐Illas, Martha, Saxena, Aditi R.
Published in Diabetes, obesity & metabolism (01.08.2024)
Published in Diabetes, obesity & metabolism (01.08.2024)
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Journal Article
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver‐Targeting Acetyl‐CoA Carboxylase Inhibitor (PF‐05221304): A Three‐Part Randomized Phase 1 Study
Bergman, Arthur, Carvajal‐Gonzalez, Santos, Tarabar, Sanela, Saxena, Aditi R., Esler, William P., Amin, Neeta B.
Published in Clinical pharmacology in drug development (01.05.2020)
Published in Clinical pharmacology in drug development (01.05.2020)
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Journal Article
Pharmacokinetics and pharmacodynamics of PF‐05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects
Denney, William S., Sonnenberg, Gabriele E., Carvajal‐Gonzalez, Santos, Tuthill, Theresa, Jackson, V. Margaret
Published in British journal of clinical pharmacology (01.02.2017)
Published in British journal of clinical pharmacology (01.02.2017)
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Journal Article
Differential Loss of Presynaptic Dopaminergic Markers in Parkinsonian Monkeys
Stephenson, Diane T., Childs, Mary Abigail, Li, Qiu, Carvajal-Gonzalez, Santos, Opsahl, Alan, Tengowski, Mark, Meglasson, Martin D., Merchant, Kalpana, Emborg, Marina E.
Published in Cell transplantation (01.03.2007)
Published in Cell transplantation (01.03.2007)
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Journal Article
Effects of lasofoxifene on the pharmacokinetics and pharmacodynamics of single‐dose warfarin
Ouellet, Daniele, Bramson, Candace, Carvajal‐Gonzalez, Santos, Roman, Doina, Randinitis, Edward, Remmers, Ann, Gardner, Mark J.
Published in British journal of clinical pharmacology (01.06.2006)
Published in British journal of clinical pharmacology (01.06.2006)
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Journal Article
Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (High-Density Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated With Higher Risk of Coronary Heart Disease
Furtado, Jeremy D, Ruotolo, Giacomo, Nicholls, Stephen J, Dullea, Robert, Carvajal-Gonzalez, Santos, Sacks, Frank M
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2022)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2022)
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Journal Article
Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis
Amin, Neeta B, Carvajal-Gonzalez, Santos, Purkal, Julie, Zhu, Tong, Crowley, Collin, Perez, Sylvie, Chidsey, Kristin, Kim, Albert M, Goodwin, Bryan
Published in Science translational medicine (27.11.2019)
Published in Science translational medicine (27.11.2019)
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Journal Article
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials
Calle, Roberto A, Amin, Neeta B, Carvajal-Gonzalez, Santos, Ross, Trenton T, Bergman, Arthur, Aggarwal, Sudeepta, Crowley, Collin, Rinaldi, Anthony, Mancuso, Jessica, Aggarwal, Naresh, Somayaji, Veena, Inglot, Malgorzata, Tuthill, Theresa A, Kou, Kou, Boucher, Magalie, Tesz, Greg, Dullea, Robert, Bence, Kendra K, Kim, Albert M, Pfefferkorn, Jeffrey A, Esler, William P
Published in Nature medicine (01.10.2021)
Published in Nature medicine (01.10.2021)
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Journal Article
Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family
Lombet, A, Zujovic, V, Kandouz, M, Billardon, C, Carvajal-Gonzalez, S, Gompel, A, Rostène, W
Published in European journal of biochemistry (01.03.2001)
Published in European journal of biochemistry (01.03.2001)
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Journal Article
PS-109-Partial inhibition of de novo lipogenesis with the acetyl-CoA carboxylase inhibitor PF-05221304 does not increase circulating triglycerides in humans and is sufficient to lower steatosis in rats
Esler, William, Ross, Trenton, Bergman, Arthur, Crowley, Collin, Gonzalez, Santos Carvajal, Beebe, David, Pfefferkorn, Jeffrey A, Amin, Neeta
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging
Cline, Gary W., Naganawa, Mika, Chen, Laigao, Chidsey, Kristin, Carvajal-Gonzalez, Santos, Pawlak, Sylvester, Rossulek, Michelle, Zhang, Yanwei, Bini, Jason, McCarthy, Timothy J., Carson, Richard E., Calle, Roberto A.
Published in Diabetologia (01.12.2018)
Published in Diabetologia (01.12.2018)
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Journal Article
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition
Esler, William P, Tesz, Gregory J, Hellerstein, Marc K, Beysen, Carine, Sivamani, Raja, Turner, Scott M, Watkins, Steven M, Amor, Paul A, Carvajal-Gonzalez, Santos, Geoly, Frank J, Biddle, Kathleen E, Purkal, Julie J, Fitch, Mark, Buckeridge, Clare, Silvia, Annette M, Griffith, David A, Gorgoglione, Matthew, Hassoun, Lauren, Bosanac, Suzana S, Vera, Nicholas B, Rolph, Timothy P, Pfefferkorn, Jeffrey A, Sonnenberg, Gabriele E
Published in Science translational medicine (15.05.2019)
Published in Science translational medicine (15.05.2019)
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The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-Blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID
Krumholz, Harlan M., Sawano, Mitsuaki, Bhattacharjee, Bornali, Caraballo, César, Khera, Rohan, Li, Shu-Xia, Herrin, Jeph, Coppi, Andreas, Holub, Julie, Henriquez, Yashira, Johnson, Maria A., Goddard, Theresa B., Rocco, Erica, Hummel, Amy C., AL Mouslmani, Mohammad, Putrino, David F., Carr, Kevin D., Carvajal-Gonzalez, Santos, Charnas, Lawrence, De Jesus, Magdia, Ziegler, Frank W., Iwasaki, Akiko
Published in The American journal of medicine (10.05.2024)
Published in The American journal of medicine (10.05.2024)
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Journal Article
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Ross, Trenton T., Crowley, Collin, Kelly, Kenneth L., Rinaldi, Anthony, Beebe, David A., Lech, Matthew P., Martinez, Robert V., Carvajal-Gonzalez, Santos, Boucher, Magalie, Hirenallur-Shanthappa, Dinesh, Morin, Jeffrey, Opsahl, Alan C., Vargas, Sarah R., Bence, Kendra K., Pfefferkorn, Jeffrey A., Esler, William P.
Published in Cellular and molecular gastroenterology and hepatology (01.01.2020)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2020)
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Journal Article
Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes
Griffith, David A, Kung, Daniel W, Esler, William P, Amor, Paul A, Bagley, Scott W, Beysen, Carine, Carvajal-Gonzalez, Santos, Doran, Shawn D, Limberakis, Chris, Mathiowetz, Alan M, McPherson, Kirk, Price, David A, Ravussin, Eric, Sonnenberg, Gabriele E, Southers, James A, Sweet, Laurel J, Turner, Scott M, Vajdos, Felix F
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Journal Article
PS-132-The acetyl-CoA carboxylase inhibitor PF-05221304 exerts direct effects on hepatic inflammation and fibrosis independent of benefits on steatosis
Ross, Trenton, Kelly, Kenneth, Rinaldi, Anthony, Lech, Matthew, Martinez, Robert, Crowley, Collin, Gonzalez, Santos Carvajal, Boucher, Magalie, Shanthappa, Dinesh Hirenallur, Morin, Jeffrey, Opsahl, Alan C., RVargas, Sarah, Bence, Kendra, Pfefferkorn, Jeffrey A, Esler, William
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
De novo lipogenesis is essential for platelet production in humans
Kelly, Kenneth L, Reagan, William J, Sonnenberg, Gabriele E, Clasquin, Michelle, Hales, Katherine, Asano, Shoh, Amor, Paul A, Carvajal-Gonzalez, Santos, Shirai, Norimitsu, Matthews, Marcy D, Li, Kelvin W, Hellerstein, Marc K, Vera, Nicholas B, Ross, Trenton T, Cappon, Gregg, Bergman, Arthur, Buckeridge, Clare, Sun, Zhongyuan, Qejvanaj, Enida Ziso, Schmahai, Theodore, Beebe, David, Pfefferkorn, Jeffrey A, Esler, William P
Published in Nature metabolism (01.10.2020)
Published in Nature metabolism (01.10.2020)
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Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin
Dubins, Jeffrey S, Sanchez-Alavez, Manuel, Zhukov, Victor, Sanchez-Gonzalez, Alejandro, Moroncini, Gianluca, Carvajal-Gonzalez, Santos, Hadcock, John R, Bartfai, Tamas, Conti, Bruno
Published in Metabolism, clinical and experimental (01.10.2012)
Published in Metabolism, clinical and experimental (01.10.2012)
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Journal Article
Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes
Griffith, David A., Kung, Daniel W., Esler, William P., Amor, Paul A., Bagley, Scott W., Beysen, Carine, Carvajal-Gonzalez, Santos, Doran, Shawn D., Limberakis, Chris, Mathiowetz, Alan M., McPherson, Kirk, Price, David A., Ravussin, Eric, Sonnenberg, Gabriele E., Southers, James A., Sweet, Laurel J., Turner, Scott M., Vajdos, Felix F.
Published in Journal of medicinal chemistry (26.12.2014)
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Published in Journal of medicinal chemistry (26.12.2014)
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