Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
Carvajal, Luis A, Neriah, Daniela Ben, Senecal, Adrien, Benard, Lumie, Thiruthuvanathan, Victor, Yatsenko, Tatyana, Narayanagari, Swathi-Rao, Wheat, Justin C, Todorova, Tihomira I, Mitchell, Kelly, Kenworthy, Charles, Guerlavais, Vincent, Annis, D Allen, Bartholdy, Boris, Will, Britta, Anampa, Jesus D, Mantzaris, Ioannis, Aivado, Manuel, Singer, Robert H, Coleman, Robert A, Verma, Amit, Steidl, Ulrich
Published in Science translational medicine (11.04.2018)
Published in Science translational medicine (11.04.2018)
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Journal Article
Pharmacological inhibition of the transcription factor PU.1 in leukemia
Antony-Debré, Iléana, Paul, Ananya, Leite, Joana, Mitchell, Kelly, Kim, Hye Mi, Carvajal, Luis A, Todorova, Tihomira I, Huang, Kenneth, Kumar, Arvind, Farahat, Abdelbasset A, Bartholdy, Boris, Narayanagari, Swathi-Rao, Chen, Jiahao, Ambesi-Impiombato, Alberto, Ferrando, Adolfo A, Mantzaris, Ioannis, Gavathiotis, Evripidis, Verma, Amit, Will, Britta, Boykin, David W, Wilson, W David, Poon, Gregory Mk, Steidl, Ulrich
Published in The Journal of clinical investigation (01.12.2017)
Published in The Journal of clinical investigation (01.12.2017)
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Journal Article
p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints
Lukin, Dana J, Carvajal, Luis A, Liu, Wen-jun, Resnick-Silverman, Lois, Manfredi, James J
Published in Molecular cancer research (01.01.2015)
Published in Molecular cancer research (01.01.2015)
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Journal Article
The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo
Hamard, Pierre-Jacques, Barthelery, Nicolas, Hogstad, Brandon, Mungamuri, Sathish Kumar, Tonnessen, Crystal A, Carvajal, Luis A, Senturk, Emir, Gillespie, Virginia, Aaronson, Stuart A, Merad, Miriam, Manfredi, James J
Published in Genes & development (01.09.2013)
Published in Genes & development (01.09.2013)
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Journal Article
Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity
Zhou, Xiaolei, Singh, Madhurendra, Sanz Santos, Gema, Guerlavais, Vincent, Carvajal, Luis A, Aivado, Manuel, Zhan, Yue, Oliveira, Mariana M S, Westerberg, Lisa S, Annis, D Allen, Johnsen, John Inge, Selivanova, Galina
Published in Cancer discovery (01.12.2021)
Published in Cancer discovery (01.12.2021)
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Journal Article
IL1RAP potentiates multiple oncogenic signaling pathways in AML
Mitchell, Kelly, Barreyro, Laura, Todorova, Tihomira I, Taylor, Samuel J, Antony-Debré, Iléana, Narayanagari, Swathi-Rao, Carvajal, Luis A, Leite, Joana, Piperdi, Zubair, Pendurti, Gopichand, Mantzaris, Ioannis, Paietta, Elisabeth, Verma, Amit, Gritsman, Kira, Steidl, Ulrich
Published in The Journal of experimental medicine (04.06.2018)
Published in The Journal of experimental medicine (04.06.2018)
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Journal Article
PB1889: KB‐LANRA 1001: A PHASE 1B/2 STUDY ON SAFETY, PK, PD, AND PRELIMINARY EFFICACY OF THE SELECTIVE SYK INHIBITOR LANRAPLENIB IN COMBINATION WITH THE FLT3 INHIBITOR GILTERITINIB, IN FLT3‐MUTATED R/R AML
Patel, Anand, Michaelis, Laura, Schiller, Gary, Swords, Ronan, Morris, Lawrence E., Carvajal, Luis A., Bray, Gordon, Olek, Elizabeth A., Cutler, Richard, Dimartino, Jorge, Stein, Eytan
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
Ueda, Koki, Kumari, Rajni, Schwenger, Emily, Wheat, Justin C., Bohorquez, Oliver, Narayanagari, Swathi-Rao, Taylor, Samuel J., Carvajal, Luis A., Pradhan, Kith, Bartholdy, Boris, Todorova, Tihomira I., Goto, Hiroki, Sun, Daqian, Chen, Jiahao, Shan, Jidong, Song, Yinghui, Montagna, Cristina, Xiong, Shunbin, Lozano, Guillermina, Pellagatti, Andrea, Boultwood, Jacqueline, Verma, Amit, Steidl, Ulrich
Published in Cancer cell (12.04.2021)
Published in Cancer cell (12.04.2021)
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Journal Article
The Combination of Lanraplenib, a Selective SYK Inhibitor, and Gilteritinib, a FLT3 Inhibitor, Targets Aberrant Proliferation and Differentiation Blockade in Acute Myeloid Leukemia
Carvajal, Luis A., McKeown, Michael R., Hood, Tressa, Guo, Linlin, Lin, Charles Y., DiMartino, Jorge F.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Responses in patients with AML and treated with entospletinib monotherapy
Lin, Tara L., Cutler, Richard E., Olek, Elizabeth, Carvajal, Luis A., DiMartino, Jorge F., Walker, Alison R.
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Combined Single Cell Flow Cytometry and Imaging Analyses Reveal Immunomodulatory Effects Exerted By Targeted Phospho-SYK Inhibitors with Elevated Sensitivity in NPM1 Mutated AML
Robinson, Bridget A, Sergeev, Philipp, Kosaka, Yoko, Jacob, Thomas, Kaempf, Andy, Lind, Evan F., Tognon, Cristina, Carvajal, Luis A., DiMartino, Jorge F., Heckman, Caroline A., Vu, Tania Q
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
KB-Lanra 1001: A Phase 1b/2 Study of Safety, PK, PD, and Preliminary Efficacy of the Selective SYK Inhibitor Lanraplenib in Combination with the FLT3 Inhibitor Gilteritinib in FLT3-Mutated R/R AML
Arnan, Monteserrat, Patel, Anand Ashwin, Esteve, Jordi, Morris, Lawrence, Schiller, Gary J., Swords, Ronan T., Alonso-Dominguez, Juan M., Michaelis, Laura C., Daver, Naval, Carvajal, Luis A., Bray, Gordon, Olek, Elizabeth, Cutler, Richard E., DiMartino, Jorge F., Stein, Eytan M.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
The Novel Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) Platform Identifies Synergistic Activity of Lanraplenib and Ruxolitinib in Hematological Malignancies
Pandey, Akanksha, Carvajal, Luis A., Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Hood, Tressa, Guo, Linlin, Hopkins, Tamara D, Obholzer, Nikolaus, McKeown, Michael R., DiMartino, Jorge F., Lin, Charles Y.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Development of a Standardized, DNA-Based Next Generation Sequencing Assay for Assessment of Measurable Residual Disease (MRD) in Acute Myeloid Leukemia (AML) As the Primary Endpoint in the Agility Study
Carvajal, Luis A., Hood, Tressa, Bevan, Yana, Dillon, Richard, Potter, Nicola, Thomas, Ian, Johnson, Sean, Othman, Jad, Gilkes, Amanda, Russell, Nigel H., Sikorski, Adam, Ellis, Pete, Marsico, Giovanni, Jones, Greg, MacKenzie, Crystal, To, Zung, DiMartino, Jorge, Kumar, Pavan
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Abstract C064: The investigational peptide drug ALRN-6924, a dual inhibitor of MDMX and MDM2, is an effective myelopreservation agent
Carvajal, Luis A, Sutton, David, Mounir, Mariam, McClanaghan, Joseph, Guerlavais, Vincent, Aivado, Manuel, Vukovic, Vojislav, Annis, Allen
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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