A Win–Win Solution in Oral Delivery of Lipophilic Drugs: Supersaturation via Amorphous Solid Dispersions Increases Apparent Solubility without Sacrifice of Intestinal Membrane Permeability
Miller, Jonathan M, Beig, Avital, Carr, Robert A, Spence, Julie K, Dahan, Arik
Published in Molecular pharmaceutics (02.07.2012)
Published in Molecular pharmaceutics (02.07.2012)
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The Solubility–Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation
Miller, Jonathan M, Beig, Avital, Krieg, Brian J, Carr, Robert A, Borchardt, Thomas B, Amidon, Gregory E, Amidon, Gordon L, Dahan, Arik
Published in Molecular pharmaceutics (03.10.2011)
Published in Molecular pharmaceutics (03.10.2011)
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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity
von Geldern, Thomas W, Morton, Howard E, Clark, Rick F, Brown, Brian S, Johnston, Kelly L, Ford, Louise, Specht, Sabine, Carr, Robert A, Stolarik, Deanne F, Ma, Junli, Rieser, Matthew J, Struever, Dominique, Frohberger, Stefan J, Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D, Hübner, Marc P, Hoerauf, Achim, Taylor, Mark J, Ward, Stephen A, Marsh, Kennan, Kempf, Dale J
Published in PLoS neglected tropical diseases (01.02.2019)
Published in PLoS neglected tropical diseases (01.02.2019)
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Randomized, Phase II Study of the Thrombospondin-1-Mimetic Angiogenesis Inhibitor ABT-510 in Patients With Advanced Soft Tissue Sarcoma
BAKER, Laurence H, ROWINSKY, Eric K, MENDELSON, David, HUMERICKHOUSE, Rod A, KNIGHT, Raymond A, JIANG QIAN, CARR, Robert A, GORDON, Gary B, DEMETRI, George D
Published in Journal of clinical oncology (01.12.2008)
Published in Journal of clinical oncology (01.12.2008)
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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Thrombospondin-1–Mimetic Angiogenesis Inhibitor ABT-510 in Patients With Advanced Cancer
Hoekstra, Ronald, de Vos, Filip Y F L, Eskens, Ferry A L M, Gietema, Jourik A, van der Gaast, Ate, Groen, Harry J M, Knight, Raymond A, Carr, Robert A, Humerickhouse, Rod A, Verweij, Jaap, de Vries, Elisabeth G E
Published in Journal of clinical oncology (01.08.2005)
Published in Journal of clinical oncology (01.08.2005)
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Atrasentan, an Endothelin-Receptor Antagonist for Refractory Adenocarcinomas: Safety and Pharmacokinetics
CARDUCCI, Michael A, NELSON, Joel B, JANUS, Todd J, ANDRE, Amy, HOSMANE, Balakrishna S, PADLEY, Robert J, BOWLING, M. Kathy, ROGERS, Theresa, EISENBERGER, Mario A, SINIBALDI, Victoria, DONEHOWER, Ross, LEAHY, Terri L, CARR, Robert A, ISAACSON, Jeffrey D
Published in Journal of clinical oncology (15.04.2002)
Published in Journal of clinical oncology (15.04.2002)
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Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease
Rosebraugh, Matthew, Voight, Eric A., Moussa, Ehab M., Jameel, Feroz, Lou, Xiaochun, Zhang, Geoff G. Z., Mayer, Peter T., Stolarik, Deanne, Carr, Robert A., Enright, Brian P., Liu, Wei, Facheris, Maurizio F., Kym, Philip R.
Published in Annals of neurology (01.07.2021)
Published in Annals of neurology (01.07.2021)
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Head-To-Head Comparison of Different Solubility-Enabling Formulations of Etoposide and Their Consequent Solubility–Permeability Interplay
Beig, Avital, Miller, Jonathan M., Lindley, David, Carr, Robert A., Zocharski, Philip, Agbaria, Riad, Dahan, Arik
Published in Journal of pharmaceutical sciences (01.09.2015)
Published in Journal of pharmaceutical sciences (01.09.2015)
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Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound—The Venetoclax Story
Emami Riedmaier, Arian, Lindley, David J., Hall, Jeffrey A., Castleberry, Steven, Slade, Russell T., Stuart, Patricia, Carr, Robert A., Borchardt, Thomas B., Bow, Daniel A.J., Nijsen, Marjoleen
Published in Journal of pharmaceutical sciences (01.01.2018)
Published in Journal of pharmaceutical sciences (01.01.2018)
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Dual effects of rifampin on the pharmacokinetics of atrasentan
Xiong, Hao, Carr, Robert A, Locke, Charles S, Katz, David A, Achari, Ramanuj, Doan, Thao T, Wang, Perry, Jankowski, James R, Sleep, Darryl J
Published in Journal of clinical pharmacology (01.04.2007)
Published in Journal of clinical pharmacology (01.04.2007)
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A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity
Alami, Negar, Carter, David C, Kwatra, Nisha V, Zhao, Weihan, Snodgrass, Linda, Porcalla, Ariel R, Klein, Cheri E, Cohen, Daniel E, Gallenberg, Loretta, Neenan, Melina, Carr, Robert A, Marsh, Kennan C, Kempf, Dale J
Published in PLoS neglected tropical diseases (10.07.2023)
Published in PLoS neglected tropical diseases (10.07.2023)
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Dose-Ranging Study of the Safety and Pharmacokinetics of Atrasentan in Patients with Refractory Malignancies
RYAN, Christopher W, VOGELZANG, Nicholas J, VOKES, Everett E, KINDLER, Hedy L, UNDEVIA, Samir D, HUMERICKHOUSE, Rod, ANDRE, Amy K, QIANG WANG, CARR, Robert A, RATAIN, Mark J
Published in Clinical cancer research (01.07.2004)
Published in Clinical cancer research (01.07.2004)
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Prediction of Clinical Drug–Drug Interactions of Veliparib (ABT-888) with Human Renal Transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K)
Kikuchi, Ryota, Lao, Yanbin, Bow, Daniel A.J., Chiou, William J., Andracki, Mark E., Carr, Robert A., Voorman, Richard L., De Morais, Sonia M.
Published in Journal of pharmaceutical sciences (01.12.2013)
Published in Journal of pharmaceutical sciences (01.12.2013)
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Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors
Randolph, John T., Li, Tongmei, Chris Krueger, A., Heyman, Howard R., Chen, Hui-Ju, Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle, Krishnan, Preethi, Wagner, Rolf, DeGoey, David A.
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
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Synthesis and evaluation of 2′-dihalo ribonucleotide prodrugs with activity against hepatitis C virus
Chris Krueger, A., Chen, Hui-Ju, Randolph, John T., Brown, Brian S., Halvorsen, Geoff T., Heyman, Howard R., Li, Tongmei, Marvin, Christopher C., Shanley, Jason P., Voight, Eric A., Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle L., Krishnan, Preethi, Henry, Rodger F., Wagner, Rolf, DeGoey, David A.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling
Gao, Yi, Carr, Robert A, Spence, Julie K, Wang, Weili W, Turner, Teresa M, Lipari, John M, Miller, Jonathan M
Published in Molecular pharmaceutics (04.10.2010)
Published in Molecular pharmaceutics (04.10.2010)
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In vitro characterization of drug metabolizing enzymes and transporters to enable a mechanistic drug-drug interaction assessment for venetoclax
Kikuchi, Ryota, Shebley, Mohamad, Bow, Daniel A.J., Carr, Robert A., Nijsen, Marjoleen, de Morais, Sonia M.
Published in Drug metabolism and pharmacokinetics (01.01.2017)
Published in Drug metabolism and pharmacokinetics (01.01.2017)
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Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751
Innocenti, Federico, Ramírez, Jacqueline, Obel, Jennifer, Xiong, Julia, Mirkov, Snezana, Chiu, Yi-Lin, Katz, David A, Carr, Robert A, Zhang, Wei, Das, Soma, Adjei, Araba, Moyer, Ann M, Chen, Pei Xian, Krivoshik, Andrew, Medina, Diane, Gordon, Gary B, Ratain, Mark J, Sahelijo, Leonardo, Weinshilboum, Richard M, Fleming, Gini F, Bhathena, Anahita
Published in Pharmacogenetics and genomics (01.07.2013)
Published in Pharmacogenetics and genomics (01.07.2013)
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Steady-State Pharmacokinetics and Electrocardiographic Pharmacodynamics of Clarithromycin and Loratadine after Individual or Concomitant Administration
CARR, R. A, EDMONDS, A, SHI, H, LOCKE, C. S, GUSTAVSON, L. E, CRAFT, J. C, HARRIS, S. I, PALMER, R
Published in Antimicrobial Agents and Chemotherapy (01.05.1998)
Published in Antimicrobial Agents and Chemotherapy (01.05.1998)
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