Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors: P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties
Semple, J. Edward, Rowley, David C, Brunck, Terence K, Ha-Uong, Theresa, Minami, Nathaniel K, Owens, Timothy D, Tamura, Susan Y, Goldman, Erick A, Siev, Daniel V, Ardecky, Robert J, Carpenter, Stephen H, Ge, Yu, Richard, Brigitte M, Nolan, Thomas G, Håkanson, Kjell, Tulinsky, Al, Nutt, Ruth F, Ripka, William C
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Journal Article
Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
Tamura, Susan Y., Edward Semple, J., Reiner, John E., Goldman, Erick A., Brunck, Terence K., Lim-Wilby, Marguerita S., Carpenter, Stephen H., Rote, William E., Oldeshulte, Gerard L., Richard, Brigitte M., Nutt, Ruth F., Ripka, William C.
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
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Journal Article
AROMATISCHE HETEROCYCLISCHE DERIVATE ALS ENZYMINHIBITOREN
SEMPLE, JOSEPH EDWARD, ARDECKY, ROBERT JOHN, NUTT, RUTH F, RIPKA, WILLIAM CHARLES, GE, YU, CARPENTER, STEPHEN H, ABELMAN, MATTHEW MARK, TAMURA, SUSAN YOSHIKO, BRUNCK, TERENCE KEVIN, LIM-WILBY, MARGUERITA S
Year of Publication 05.12.2002
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Year of Publication 05.12.2002
Patent
AROMATISCHE HETEROCYCLISCHE DERIVATE ALS ENZYMINHIBITOREN
SEMPLE, JOSEPH EDWARD, ARDECKY, ROBERT JOHN, NUTT, RUTH F, RIPKA, WILLIAM CHARLES, GE, YU, CARPENTER, STEPHEN H, ABELMAN, MATTHEW MARK, TAMURA, SUSAN YOSHIKO, BRUNCK, TERENCE KEVIN, LIM-WILBY, MARGUERITA S
Year of Publication 15.05.2002
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Year of Publication 15.05.2002
Patent
AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS
SEMPLE, JOSEPH EDWARD, ARDECKY, ROBERT JOHN, NUTT, RUTH F, RIPKA, WILLIAM CHARLES, GE, YU, CARPENTER, STEPHEN H, ABELMAN, MATTHEW MARK, TAMURA, SUSAN YOSHIKO, BRUNCK, TERENCE KEVIN, LIM-WILBY, MARGUERITA S
Year of Publication 08.05.2002
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Year of Publication 08.05.2002
Patent
3-amino-1,2-dihydropyrid-1-yl(and 5-amino-1,6-dihydro-6-oxo(and 5,6-dioxo)pyrimidin-1-yl)-acetyl-argininal derivatives, useful for the treatment of blood coagulation and thrombosis
SEMPLE, JOSEPH EDWARD, ARDECKY, ROBERT JOHN, NUTT, RUTH F, RIPKA, WILLIAM CHARLES, CARPENTER, STEPHEN H, ABELMAN, MATTHEW MARK, GE, YU, TAMURA, SUSAN YOSHIKO, BRUNCK, TERENCE KEVIN, LIM-WILBY, MARGUERITA S
Year of Publication 30.03.2001
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Year of Publication 30.03.2001
Patent
Aromatic heterocyclic derivatives as enzyme inhibitors
TAMURA; SUSAN YOSHIKO, GE; YU, CARPENTER; STEPHEN H, BRUNCK; TERENCE K, RIPKA; WILLIAM CHARLES, SEMPLE; JOSEPH EDWARD, ARDECKY; ROBERT JOHN
Year of Publication 19.08.1997
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Year of Publication 19.08.1997
Patent
Aromatic heterocyclic derivatives as enzyme inhibitors
TAMURA; SUSAN YOSHIKO, GE; YU, CARPENTER; STEPHEN H, BRUNCK; TERENCE K, RIPKA; WILLIAM CHARLES, SEMPLE; JOSEPH EDWARD, ARDECKY; ROBERT JOHN
Year of Publication 12.08.1997
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Year of Publication 12.08.1997
Patent
Aromatic heterocyclic derivatives as enzyme inhibitors
ABELMAN; MATTHEW M, TAMURA; SUSAN YOSHIKO, GE; YU, LIM-WILBY; MARGUERITA S. L, CARPENTER; STEPHEN H, BRUNCK; TERENCE K, RIPKA; WILLIAM CHARLES, NUTT; RUTH F, SEMPLE; JOSEPH EDWARD, ARDECKY; ROBERT JOHN
Year of Publication 04.01.2000
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Year of Publication 04.01.2000
Patent
Aromatic hetherocyclic derivatives as enzyme inhibitors
ABELMAN; MATTHEW M, TAMURA; SUSAN YOSHIKO, GE; YU, LIM-WILBY; MARGUERITA S. L, CARPENTER; STEPHEN H, BRUNCK; TERENCE K, RIPKA; WILLIAM CHARLES, NUTT; RUTH F, SEMPLE; JOSEPH EDWARD, ARDECKY; ROBERT JOHN
Year of Publication 28.12.1999
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Year of Publication 28.12.1999
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AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS
SEMPLE,JOSEPH EDWARD, CARPENTER,STEPHEN H, NUTT,RUTH F, TAMURA,SUSAN YOSHIKO, RIPKA,WILLIAM CHARLES, ARDECKY,ROBERT JOHN, LIM-WILBY,MARGUERITA S, BRUNCK,TERENCE KEVIN, GE,YU, ABELMAN,MATTHEW MARK
Year of Publication 28.09.1998
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Year of Publication 28.09.1998
Patent
Aromatic heterocyclic derivatives as enzyme inhibitors
MARGUERITA S LIM-WILBY, SUSAN YOSHIKO TAMURA, YU GE, WILLIAM CHARLES RIPKA, RUTH F. NUTT, ROBERT JOHN ARDECKY, MATTHEW MARK ABELMAN, TERENCE KEVIN BRUNCK, JOSEPH EDWARD SEMPLE, STEPHEN H CARPENTER
Year of Publication 02.07.1998
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Year of Publication 02.07.1998
Patent
Derivados heterocíclicos aromáticos como inibidores de enzimas
SUSAN YOSHIKO TAMURA, YU GE, STEPHEN H. CARPENTER, WILLIAM CHARLES RIPKA, MARGUERITA S. LIM-WILBY, RUTH F. NUTT, ROBERT JOHN ARDECKY, MATTHEW MARK ABELMAN, TERENCE KEVIN BRUNCK, JOSEPH EDWARD SEMPLE
Year of Publication 30.12.1997
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Year of Publication 30.12.1997
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AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS
SEMPLE, JOSEPH EDWARD, ARDECKY, ROBERT JOHN, NUTT, RUTH F, RIPKA, WILLIAM CHARLES, GE, YU, CARPENTER, STEPHEN H, ABELMAN, MATTHEW MARK, TAMURA, SUSAN YOSHIKO, BRUNCK, TERENCE KEVIN, LIM-WILBY, MARGUERITA S
Year of Publication 05.11.1997
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Year of Publication 05.11.1997
Patent
Aromatic heterocyclic derivatives as enzyme inhibitors
MARGUERITA S LIM-WILBY, SUSAN YOSHIKO TAMURA, YU GE, WILLIAM CHARLES RIPKA, RUTH F. NUTT, ROBERT JOHN ARDECKY, MATTHEW MARK ABELMAN, TERENCE KEVIN BRUNCK, JOSEPH EDWARD SEMPLE, STEPHEN H CARPENTER
Year of Publication 03.07.1996
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Year of Publication 03.07.1996
Patent
AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS
NUTT, RUTH, F, ARDECKY, ROBERT, JOHN, GE, YU, LIM-WILBY, MARGUERITA, S, CARPENTER, STEPHEN, H, RIPKA, WILLIAM, CHARLES, ABELMAN, MATTHEW, MARK, TAMURA, SUSAN, YOSHIKO, BRUNCK, TERENCE, KEVIN, SEMPLE, JOSEPH, EDWARD
Year of Publication 20.06.1996
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Year of Publication 20.06.1996
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AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS
SEMPLE, JOSEPH EDWARD, ARDECKY, ROBERT JOHN, NUTT, RUTH F, GE, YU, RIPKA, WILLIAM CHARLES, ABELMAN, MATTHEW MARK, CARPENTER, STEPHEN H, TAMURA, SUSAN YOSHIKO, BRUNCK, TERENCE KEVIN, LIM-WILBY, MARGUERITA S
Year of Publication 20.06.1996
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Year of Publication 20.06.1996
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