Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer
Michaloglou, Chrysiis, Crafter, Claire, Siersbaek, Rasmus, Delpuech, Oona, Curwen, Jon O, Carnevalli, Larissa S, Staniszewska, Anna D, Polanska, Urszula M, Cheraghchi-Bashi, Azadeh, Lawson, Mandy, Chernukhin, Igor, McEwen, Robert, Carroll, Jason S, Cosulich, Sabina C
Published in Molecular cancer therapeutics (01.05.2018)
Published in Molecular cancer therapeutics (01.05.2018)
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Journal Article
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Scognamiglio, Roberta, Cabezas-Wallscheid, Nina, Thier, Marc Christian, Altamura, Sandro, Reyes, Alejandro, Prendergast, Áine M., Baumgärtner, Daniel, Carnevalli, Larissa S., Atzberger, Ann, Haas, Simon, von Paleske, Lisa, Boroviak, Thorsten, Wörsdörfer, Philipp, Essers, Marieke A.G., Kloz, Ulrich, Eisenman, Robert N., Edenhofer, Frank, Bertone, Paul, Huber, Wolfgang, van der Hoeven, Franciscus, Smith, Austin, Trumpp, Andreas
Published in Cell (11.02.2016)
Published in Cell (11.02.2016)
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Journal Article
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
Carnevalli, Larissa S., Masuda, Kouhei, Frigerio, Francesca, Le Bacquer, Olivier, Um, Sung Hee, Gandin, Valentina, Topisirovic, Ivan, Sonenberg, Nahum, Thomas, George, Kozma, Sara C.
Published in Developmental cell (18.05.2010)
Published in Developmental cell (18.05.2010)
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Journal Article
Therapeutic Approaches Targeting the Natural Killer-Myeloid Cell Axis in the Tumor Microenvironment
Carnevalli, Larissa S, Ghadially, Hormas, Barry, Simon T
Published in Frontiers in immunology (19.04.2021)
Published in Frontiers in immunology (19.04.2021)
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Journal Article
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
Basilico, Silvia, Wang, Xiaonan, Kennedy, Alison, Tzelepis, Konstantinos, Giotopoulos, George, Kinston, Sarah J., Quiros, Pedro M., Wong, Kim, Adams, David J., Carnevalli, Larissa S., Huntly, Brian J. P., Vassiliou, George S., Calero-Nieto, Fernando J., Göttgens, Berthold
Published in Nature communications (16.03.2020)
Published in Nature communications (16.03.2020)
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Journal Article
Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery
Taylor, Molly A., Hughes, Adina M., Walton, Josephine, Coenen-Stass, Anna M. L., Magiera, Lukasz, Mooney, Lorraine, Bell, Sigourney, Staniszewska, Anna D., Sandin, Linda C., Barry, Simon T., Watkins, Amanda, Carnevalli, Larissa S., Hardaker, Elizabeth L.
Published in Journal for immunotherapy of cancer (28.11.2019)
Published in Journal for immunotherapy of cancer (28.11.2019)
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Journal Article
Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer
Revenko, Alexey, Carnevalli, Larissa S, Sinclair, Charles, Johnson, Ben, Peter, Alison, Taylor, Molly, Hettrick, Lisa, Chapman, Melissa, Klein, Stephanie, Solanki, Anisha, Gattis, Danielle, Watt, Andrew, Hughes, Adina M, Magiera, Lukasz, Kar, Gozde, Ireland, Lucy, Mele, Deanna A, Sah, Vasu, Singh, Maneesh, Walton, Josephine, Mairesse, Maelle, King, Matthew, Edbrooke, Mark, Lyne, Paul, Barry, Simon T, Fawell, Stephen, Goldberg, Frederick W, MacLeod, A Robert
Published in Journal for immunotherapy of cancer (01.04.2022)
Published in Journal for immunotherapy of cancer (01.04.2022)
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Journal Article
PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8 + T-cell activity
Carnevalli, Larissa S, Sinclair, Charles, Taylor, Molly A, Gutierrez, Pablo Morentin, Langdon, Sophie, Coenen-Stass, Anna M L, Mooney, Lorraine, Hughes, Adina, Jarvis, Laura, Staniszewska, Anna, Crafter, Claire, Sidders, Ben, Hardaker, Elizabeth, Hudson, Kevin, Barry, Simon T
Published in Journal for immunotherapy of cancer (27.12.2018)
Published in Journal for immunotherapy of cancer (27.12.2018)
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Journal Article
Modeling Dose and Schedule Effects of AZD2811 Nanoparticles Targeting Aurora B Kinase for Treatment of Diffuse Large B-cell Lymphoma
Floc'h, Nicolas, Ashton, Susan, Ferguson, Douglas, Taylor, Paula, Carnevalli, Larissa S, Hughes, Adina M, Harris, Emily, Hattersley, Maureen, Wen, Shenghua, Curtis, Nicola J, Pilling, James E, Young, Lucy A, Maratea, Kim, Pease, Elizabeth J, Barry, Simon T
Published in Molecular cancer therapeutics (01.05.2019)
Published in Molecular cancer therapeutics (01.05.2019)
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Journal Article
Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity
Langdon, Sophie, Hughes, Adina, Taylor, Molly A., Kuczynski, Elizabeth A., Mele, Deanna A., Delpuech, Oona, Jarvis, Laura, Staniszewska, Anna, Cosulich, Sabina, Carnevalli, Larissa S., Sinclair, Charles
Published in Oncoimmunology (01.01.2018)
Published in Oncoimmunology (01.01.2018)
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Journal Article
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability
Kuczynski, Elizabeth A, Morlino, Giulia, Peter, Alison, Coenen‐Stass, Anna M L, Moss, Jennifer I, Wali, Neha, Delpuech, Oona, Reddy, Avinash, Solanki, Anisha, Sinclair, Charles, Calado, Dinis P, Carnevalli, Larissa S
Published in EMBO molecular medicine (08.06.2022)
Published in EMBO molecular medicine (08.06.2022)
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Journal Article
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma
Thomas, Hala Elnakat, Mercer, Carol A, Carnevalli, Larissa S, Park, Jongsun, Andersen, Jesper B, Conner, Elizabeth A, Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J, Manway, Liu, Maira, S Michel, Thorgeirsson, Snorri S, Mischel, Paul S, Thomas, George, Kozma, Sara C
Published in Science translational medicine (20.06.2012)
Published in Science translational medicine (20.06.2012)
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Journal Article
Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models
Hopcroft, Lorna, Wigmore, Eleanor M., Williamson, Stuart C., Ros, Susana, Eberlein, Cath, Moss, Jennifer I., Urosevic, Jelena, Carnevalli, Larissa S., Talbot, Sara, Bradshaw, Lauren, Blaker, Catherine, Gunda, Sreeharsha, Owenson, Venetia, Hoffmann, Scott, Sutton, Daniel, Jones, Stewart, Goodwin, Richard J. A., Willis, Brandon S., Rooney, Claire, de Bruin, Elza C., Barry, Simon T.
Published in NPJ breast cancer (05.08.2023)
Published in NPJ breast cancer (05.08.2023)
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Journal Article
Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach
Johnson, Timothy I., Minteer, Christopher J., Kottmann, Daniel, Dunlop, Charles R., Fernández, Sandra Bernaldo de Quirós, Carnevalli, Larissa S., Wallez, Yann, Lau, Alan, Richards, Frances M., Jodrell, Duncan I.
Published in EBioMedicine (01.06.2021)
Published in EBioMedicine (01.06.2021)
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Journal Article
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B
Carnevalli, Larissa S, Scognamiglio, Roberta, Cabezas-Wallscheid, Nina, Rahmig, Susann, Laurenti, Elisa, Masuda, Kohei, Jöckel, Lars, Kuck, Andrea, Sujer, Stefanie, Polykratis, Apostolos, Erlacher, Miriam, Pasparakis, Manolis, Essers, Marieke A G, Trumpp, Andreas
Published in The Journal of experimental medicine (05.05.2014)
Published in The Journal of experimental medicine (05.05.2014)
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Journal Article
Author Correction: Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models
Hopcroft, Lorna, Wigmore, Eleanor M., Williamson, Stuart C., Ros, Susana, Eberlein, Cath, Moss, Jennifer I., Urosevic, Jelena, Carnevalli, Larissa S., Talbot, Sara, Bradshaw, Lauren, Blaker, Catherine, Gunda, Sreeharsha, Owenson, Venetia, Hoffmann, Scott, Sutton, Daniel, Jones, Stewart, Goodwin, Richard J. A., Willis, Brandon S., Rooney, Claire, de Bruin, Elza C., Barry, Simon T.
Published in NPJ breast cancer (19.09.2023)
Published in NPJ breast cancer (19.09.2023)
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Journal Article
Author Correction: Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models
Hopcroft, Lorna, Wigmore, Eleanor M., Williamson, Stuart C., Ros, Susana, Eberlein, Cath, Moss, Jennifer I., Urosevic, Jelena, Carnevalli, Larissa S., Talbot, Sara, Bradshaw, Lauren, Blaker, Catherine, Gunda, Sreeharsha, Owenson, Venetia, Hoffmann, Scott, Sutton, Daniel, Jones, Stewart, Goodwin, Richard J. A., Willis, Brandon S., Rooney, Claire, DeBruin, Elza, Barry, Simon T.
Published in NPJ breast cancer (18.08.2023)
Published in NPJ breast cancer (18.08.2023)
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Journal Article
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response
Georgopoulou, Dimitra, Callari, Maurizio, Rueda, Oscar M., Shea, Abigail, Martin, Alistair, Giovannetti, Agnese, Qosaj, Fatime, Dariush, Ali, Chin, Suet-Feung, Carnevalli, Larissa S., Provenzano, Elena, Greenwood, Wendy, Lerda, Giulia, Esmaeilishirazifard, Elham, O’Reilly, Martin, Serra, Violeta, Bressan, Dario, Mills, Gordon B., Ali, H. Raza, Cosulich, Sabina S., Hannon, Gregory J., Bruna, Alejandra, Caldas, Carlos
Published in Nature communications (31.03.2021)
Published in Nature communications (31.03.2021)
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Journal Article
Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer
Harrod, Alison, Lai, Chun-Fui, Goldsbrough, Isabella, Simmons, Georgia M., Oppermans, Natasha, Santos, Daniela B., Győrffy, Balazs, Allsopp, Rebecca C., Toghill, Bradley J., Balachandran, Kirsty, Lawson, Mandy, Morrow, Christopher J., Surakala, Manasa, Carnevalli, Larissa S., Zhang, Pei, Guttery, David S., Shaw, Jacqueline A., Coombes, R. Charles, Buluwela, Lakjaya, Ali, Simak
Published in Oncogene (28.10.2022)
Published in Oncogene (28.10.2022)
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Journal Article
The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance
Lawson, Mandy, Cureton, Natalie, Ros, Susana, Cheraghchi-Bashi, Azadeh, Urosevic, Jelena, D'Arcy, Sophie, Delpuech, Oona, DuPont, Michelle, Fisher, David I, Gangl, Eric T, Lewis, Hilary, Trueman, Dawn, Wali, Neha, Williamson, Stuart C, Moss, Jennifer, Montaudon, Elodie, Derrien, Heloise, Marangoni, Elisabetta, Miragaia, Ricardo J, Gagrica, Sladjana, Morentin-Gutierrez, Pablo, Moss, Thomas A, Maglennon, Gareth, Sutton, Daniel, Polanski, Radoslaw, Rosen, Alan, Cairns, Jonathan, Zhang, Pei, Sánchez-Guixé, Mònica, Serra, Violeta, Critchlow, Susan E, Scott, James S, Lindemann, Justin P O, Barry, Simon T, Klinowska, Teresa, Morrow, Christopher J, Carnevalli, Larissa
Published in Cancer research (Chicago, Ill.) (01.12.2023)
Published in Cancer research (Chicago, Ill.) (01.12.2023)
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