Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning
Haber, Lauric, Olson, Kara, Kelly, Marcus P., Crawford, Alison, DiLillo, David J., Tavaré, Richard, Ullman, Erica, Mao, Shu, Canova, Lauren, Sineshchekova, Olga, Finney, Jennifer, Pawashe, Arpita, Patel, Supriya, McKay, Ryan, Rizvi, Sahar, Damko, Ermelinda, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, D’Orvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Chen, Ya Ping, Thwaites, Courtney, Dudgeon, Drew, Bray, Kevin, Rafique, Ashique, Huang, Tammy, Delfino, Frank, Hermann, Aynur, Kirshner, Jessica R., Retter, Marc W., Babb, Robert, MacDonald, Douglas, Chen, Gang, Olson, William C., Thurston, Gavin, Davis, Samuel, Lin, John C., Smith, Eric
Published in Scientific reports (13.07.2021)
Published in Scientific reports (13.07.2021)
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Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues
Kelly, Marcus P, Makonnen, Sosina, Hickey, Carlos, Arnold, T Cody, Giurleo, Jason T, Tavaré, Richard, Danton, Makenzie, Granados, Christian, Chatterjee, Ishita, Dudgeon, Drew, Retter, Marc W, Ma, Dangshe, Olson, William C, Thurston, Gavin, Kirshner, Jessica R
Published in Journal for immunotherapy of cancer (01.01.2021)
Published in Journal for immunotherapy of cancer (01.01.2021)
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Journal Article
A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer
Crawford, Alison, Haber, Lauric, Kelly, Marcus P, Vazzana, Kristin, Canova, Lauren, Ram, Priyanka, Pawashe, Arpita, Finney, Jennifer, Jalal, Sumreen, Chiu, Danica, Colleton, Curtis A, Garnova, Elena, Makonnen, Sosina, Hickey, Carlos, Krueger, Pamela, DelFino, Frank, Potocky, Terra, Kuhnert, Jessica, Godin, Stephen, Retter, Marc W, Duramad, Paurene, MacDonald, Douglas, Olson, William C, Fairhurst, Jeanette, Huang, Tammy, Martin, Joel, Lin, John C, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R
Published in Science translational medicine (19.06.2019)
Published in Science translational medicine (19.06.2019)
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Abstract P134: Novel EGFRvIII-selective antibody-drug conjugate REGN3124-PBD is strongly efficacious against orthotopic glioblastoma multiforme patient derived xenografts
Kelly, Marcus P., Makonnen, Sosina, Hickey, Carlos, Mao, Shu, Zhao, Feng, Kunz, Arthur, Delfino, Frank, Nittoli, Thomas, Ma, Dangshe, Olson, William C., Thurston, Gavin, Kirshner, Jessica R.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade
DaSilva, John O, Yang, Katie, Surriga, Oliver, Nittoli, Thomas, Kunz, Arthur, Franklin, Matthew C, Delfino, Frank J, Mao, Shu, Zhao, Feng, Giurleo, Jason T, Kelly, Marcus P, Makonnen, Sosina, Hickey, Carlos, Krueger, Pamela, Foster, Randi, Chen, Zhaoyuan, Retter, Marc W, Slim, Rabih, Young, Tara M, Olson, William C, Thurston, Gavin, Daly, Christopher
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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Journal Article
Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer
Kuhnert, Frank, Chen, Guoying, Coetzee, Sandra, Thambi, Nithya, Hickey, Carlos, Shan, Jing, Kovalenko, Pavel, Noguera-Troise, Irene, Smith, Eric, Fairhurst, Jeanette, Andreev, Julian, Kirshner, Jessica R, Papadopoulos, Nicholas, Thurston, Gavin
Published in Cancer research (Chicago, Ill.) (01.10.2015)
Published in Cancer research (Chicago, Ill.) (01.10.2015)
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Journal Article
Abstract 1131: CD8 immuno-PET using a fully human mAb can detect increases in tumor-infiltrating T cells by a T cell activating immunotherapy
Tavare, Richard, Danton, Makenzie, Giurleo, Jason T., Kelly, Marcus P., Makonnen, Sosina, Hickey, Carlos, Arnold, Tomas C., Ma, Dangshe, Olson, William C., Thurston, Gavin, Kirshner, Jessica R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Antibody drug conjugates of cleavable amino-benzoyl-maytansinoids
Nittoli, Thomas, Delfino, Frank, Kelly, Marcus, Carosso, Serena, Markotan, Thomas, Kunz, Arthur, Chen, Zhaoyuan, Mao, Shu, Shan, Jing, Navarro, Elizabeth, Zhao, Feng, Makonnen, Sosina, Hickey, Carlos, Spink, Jan, Olson, William, Kirshner, Jessica R., Thurston, Gavin, Papadopoulos, Nicholas
Published in Bioorganic & medicinal chemistry (01.12.2020)
Published in Bioorganic & medicinal chemistry (01.12.2020)
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Journal Article
Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids
Nittoli, Thomas, Kelly, Marcus P., Delfino, Frank, Rudge, John, Kunz, Arthur, Markotan, Thomas, Spink, Jan, Chen, Zhaoyuan, Shan, Jing, Navarro, Elizabeth, Tait, Michele, Provoncha, Kathleen, Giurleo, Jason, Zhao, Feng, Jiang, Xiaobo, Hylton, Donna, Makonnen, Sosina, Hickey, Carlos, Kirshner, Jessica R., Thurston, Gavin, Papadopoulos, Nicholas
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
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Journal Article
Abstract 4555: Selection of CD3 affinity allows generation of T-cell redirecting bispecific antibodies with unique pharmacokinetic and biodistribution properties
Haber, Lauric, Olson, Kara, Babb, Robert, Kelly, Marcus, Crawford, Alison, Retter, Marc, DiLillo, David, Ullman, Erica, Finney, Jennifer, Canova, Lauren, Pawashe, Arpita, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, Dorvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Patel, Supriya, Tavare, Richard, Chen, Ya Ping, Chen, Gang, Olson, William, Thurston, Gavin, Lin, John Chia-Yang, Hermann, Aynur, Kirshner, Jessica, Smith, Eric J.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers
Kelly, Marcus P, Hickey, Carlos, Makonnen, Sosina, Coetzee, Sandra, Jalal, Sumreen, Wang, Yu, Delfino, Frank, Shan, Jing, Potocky, Terra B, Chatterjee, Ishita, Andreev, Julian, Kunz, Arthur, D'Souza, Christopher, Giurleo, Jason T, Nittoli, Thomas, Trail, Pamela A, Thurston, Gavin, Kirshner, Jessica R
Published in Molecular cancer therapeutics (01.07.2017)
Published in Molecular cancer therapeutics (01.07.2017)
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Journal Article
Abstract 3033: Immuno-PET detection of LAG-3 expressing intratumoral lymphocytes using the zirconium-89 radiolabeled fully human anti-LAG-3 antibody REGN3767
Kelly, Marcus P., Tavare, Richard, Giurleo, Jason T., Makonnen, Sosina, Hickey, Carlos, Danton, Makenzie A., Arnold, T Cody, Ma, Dangshe, Dai, Jie, Pei, Jerry, Kirshner, Jessica R., Olson, William C., Thurston, Gavin
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 1777: REGN4018, a novel MUC16xCD3 bispecific T-cell engager for the treatment of ovarian cancer
Crawford, Alison, Haber, Lauric, Vazzana, Kristin, Canova, Lauren, Ram, Priyanka, Principio, Jennifer, Pawashe, Arpita, Colleton, Curtis, Kelly, Marcus, Makkonen, Sosina, Hickey, Carlos, Duramad, Paurene, Godin, Stephen, Lin, John, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Immuno-PET using Zirconium-89 (^sup 89^Zr) radiolabeled fully human anti-PD-L1 antibody successfully images PD-L1 positive tumors in preclinical mouse models
Kelly, Marcus, Giurleo, Jason, Makonnen, Sosina, Hickey, Carlos, Arnold, T Cody, Ma, Dangshe, Dai, Jie, Pei, Jerry, Tavare, Richard, Kirshner, Jessica, Olson, William, Thurston, Gavin
Published in The Journal of nuclear medicine (1978) (01.05.2017)
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Published in The Journal of nuclear medicine (1978) (01.05.2017)
Journal Article
Preclinical PET imaging with the novel human antibody 89 Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues
Kelly, Marcus P, Makonnen, Sosina, Hickey, Carlos, Arnold, T Cody, Giurleo, Jason T, Tavaré, Richard, Danton, Makenzie, Granados, Christian, Chatterjee, Ishita, Dudgeon, Drew, Retter, Marc W, Ma, Dangshe, Olson, William C, Thurston, Gavin, Kirshner, Jessica R
Published in Journal for immunotherapy of cancer (01.01.2021)
Published in Journal for immunotherapy of cancer (01.01.2021)
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Journal Article
Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054
Tavaré, Richard, Danton, Makenzie, Giurleo, Jason T, Makonnen, Sosina, Hickey, Carlos, Arnold, Tomas C, Kelly, Marcus P, Fredriksson, Fanny, Bruestle, Karina, Hermann, Aynur, Ullman, Erica, Edelmann, Kurt H, Potocky, Terra, Dudgeon, Drew, Bhatt, Nikunj B, Doubrovin, Mikhail, Barry, Thomas, Kyratsous, Christos A, Gurer, Cagan, Tu, Naxin, Gartner, Hans, Murphy, Andrew, Macdonald, Lynn E, Popke, Jon, Mintz, Akiva, Griesemer, Adam, Olson, William C, Thurston, Gavin, Ma, Dangshe, Kirshner, Jessica R
Published in Cancer immunology research (04.10.2022)
Published in Cancer immunology research (04.10.2022)
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Correction: Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lymphoma
Gavin Thurston, Richard Tavare, Marcus P Kelly, Sosina Makonnen, Carlos Hickey, T Cody Arnold, Jason T Giurleo, Makenzie Danton, Christian Granados, Ishita Chatterjee, Drew Dudgeon, Marc W Retter, Dangshe Ma, William C Olson, Jessica R Kirshner
Published in Journal for immunotherapy of cancer (01.01.2021)
Published in Journal for immunotherapy of cancer (01.01.2021)
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Journal Article
Abstract C126: PRLR ADC: A novel antibody drug-conjugate for the treatment of PRLR positive breast cancer
Kelly, Marcus P., Coetzee, Sandra, Hickey, Carlos, Makonnen, Sosina, Delfino, Frank, Andreev, Julian, Kunz, Arthur, D'Souza, Christopher, Giurleo, Jason, Nittoli, Thomas, Trail, Pamela A., Papadopoulos, Nicholas, Thurston, Gavin, Kirshner, Jessica R.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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