A CRISPR toolbox to study virus–host interactions
Puschnik, Andreas S., Majzoub, Karim, Ooi, Yaw Shin, Carette, Jan E.
Published in Nature reviews. Microbiology (01.06.2017)
Published in Nature reviews. Microbiology (01.06.2017)
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Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
Marceau, Caleb D., Puschnik, Andreas S., Majzoub, Karim, Ooi, Yaw Shin, Brewer, Susan M., Fuchs, Gabriele, Swaminathan, Kavya, Mata, Miguel A., Elias, Joshua E., Sarnow, Peter, Carette, Jan E.
Published in Nature (London) (07.07.2016)
Published in Nature (London) (07.07.2016)
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RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.
Published in Molecular cell (20.11.2014)
Published in Molecular cell (20.11.2014)
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Differential and convergent utilization of autophagy components by positive-strand RNA viruses
Abernathy, Emma, Mateo, Roberto, Majzoub, Karim, van Buuren, Nick, Bird, Sara W, Carette, Jan E, Kirkegaard, Karla
Published in PLoS biology (04.01.2019)
Published in PLoS biology (04.01.2019)
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Gene essentiality and synthetic lethality in haploid human cells
Blomen, Vincent A., Májek, Peter, Jae, Lucas T., Bigenzahn, Johannes W., Nieuwenhuis, Joppe, Staring, Jacqueline, Sacco, Roberto, van Diemen, Ferdy R., Olk, Nadine, Stukalov, Alexey, Marceau, Caleb, Janssen, Hans, Carette, Jan E., Bennett, Keiryn L., Colinge, Jacques, Superti-Furga, Giulio, Brummelkamp, Thijn R.
Published in Science (American Association for the Advancement of Science) (27.11.2015)
Published in Science (American Association for the Advancement of Science) (27.11.2015)
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RNA–protein interaction detection in living cells
Ramanathan, Muthukumar, Majzoub, Karim, Rao, Deepti S, Neela, Poornima H, Zarnegar, Brian J, Mondal, Smarajit, Roth, Julien G, Gai, Hui, Kovalski, Joanna R, Siprashvili, Zurab, Palmer, Theo D, Carette, Jan E, Khavari, Paul A
Published in Nature methods (01.03.2018)
Published in Nature methods (01.03.2018)
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GPR108 Is a Highly Conserved AAV Entry Factor
Dudek, Amanda M., Zabaleta, Nerea, Zinn, Eric, Pillay, Sirika, Zengel, James, Porter, Caryn, Franceschini, Jennifer Santos, Estelien, Reynette, Carette, Jan E., Zhou, Guo Ling, Vandenberghe, Luk H.
Published in Molecular therapy (05.02.2020)
Published in Molecular therapy (05.02.2020)
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Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
Flynn, Ryan A., Belk, Julia A., Qi, Yanyan, Yasumoto, Yuki, Wei, Jin, Alfajaro, Mia Madel, Shi, Quanming, Mumbach, Maxwell R., Limaye, Aditi, DeWeirdt, Peter C., Schmitz, Cameron O., Parker, Kevin R., Woo, Elizabeth, Chang, Howard Y., Horvath, Tamas L., Carette, Jan E., Bertozzi, Carolyn R., Wilen, Craig B., Satpathy, Ansuman T.
Published in Cell (29.04.2021)
Published in Cell (29.04.2021)
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PLA2G16 represents a switch between entry and clearance of Picornaviridae
Staring, Jacqueline, von Castelmur, Eleonore, Blomen, Vincent A., van den Hengel, Lisa G., Brockmann, Markus, Baggen, Jim, Thibaut, Hendrik Jan, Nieuwenhuis, Joppe, Janssen, Hans, van Kuppeveld, Frank J. M., Perrakis, Anastassis, Carette, Jan E., Brummelkamp, Thijn R.
Published in Nature (London) (19.01.2017)
Published in Nature (London) (19.01.2017)
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A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity
Cao, Jennifer Yinuo, Poddar, Aunoy, Magtanong, Leslie, Lumb, Jennifer H., Mileur, Trevor R., Reid, Michael A., Dovey, Cole M., Wang, Jin, Locasale, Jason W., Stone, Everett, Cole, Susan P.C., Carette, Jan E., Dixon, Scott J.
Published in Cell reports (Cambridge) (05.02.2019)
Published in Cell reports (Cambridge) (05.02.2019)
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Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity
Napier, Brooke A, Brubaker, Sky W, Sweeney, Timothy E, Monette, Patrick, Rothmeier, Greggory H, Gertsvolf, Nina A, Puschnik, Andreas, Carette, Jan E, Khatri, Purvesh, Monack, Denise M
Published in The Journal of experimental medicine (17.10.2016)
Published in The Journal of experimental medicine (17.10.2016)
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Lipid droplets can promote drug accumulation and activation
Dubey, Ramin, Stivala, Craig E., Nguyen, Huy Quoc, Goo, Young-Hwa, Paul, Antoni, Carette, Jan E., Trost, Barry M., Rohatgi, Rajat
Published in Nature chemical biology (01.02.2020)
Published in Nature chemical biology (01.02.2020)
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Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
Deans, Richard M, Morgens, David W, Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A, Kampmann, Martin, Gilbert, Luke A, Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S, Carette, Jan E, Khosla, Chaitan, Bassik, Michael C
Published in Nature chemical biology (01.05.2016)
Published in Nature chemical biology (01.05.2016)
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KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses
Staring, Jacqueline, van den Hengel, Lisa G., Raaben, Matthijs, Blomen, Vincent A., Carette, Jan E., Brummelkamp, Thijn R.
Published in Cell host & microbe (09.05.2018)
Published in Cell host & microbe (09.05.2018)
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Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry
Jae, Lucas T., Raaben, Matthijs, Riemersma, Moniek, van Beusekom, Ellen, Blomen, Vincent A., Velds, Arno, Kerkhoven, Ron. M., Carette, Jan E., Topaloglu, Haluk, Meinecke, Peter, Wessels, Marja W., Lefeber, Dirk J., Whelan, Sean P., van Bokhoven, Hans, Brummelkamp, Thijn R.
Published in Science (American Association for the Advancement of Science) (26.04.2013)
Published in Science (American Association for the Advancement of Science) (26.04.2013)
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Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens
Carette, Jan E, Guimaraes, Carla P, Varadarajan, Malini, Park, Annie S, Wuethrich, Irene, Godarova, Alzbeta, Kotecki, Maciej, Cochran, Brent H, Spooner, Eric, Ploegh, Hidde L, Brummelkamp, Thijn R
Published in Science (American Association for the Advancement of Science) (27.11.2009)
Published in Science (American Association for the Advancement of Science) (27.11.2009)
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MYADM binds human parechovirus 1 and is essential for viral entry
Qiao, Wenjie, Richards, Christopher M., Kim, Youlim, Zengel, James R., Ding, Siyuan, Greenberg, Harry B., Carette, Jan E.
Published in Nature communications (24.04.2024)
Published in Nature communications (24.04.2024)
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MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
Birsoy, Kivanç, Wang, Tim, Possemato, Richard, Yilmaz, Omer H, Koch, Catherine E, Chen, Walter W, Hutchins, Amanda W, Gultekin, Yetis, Peterson, Tim R, Carette, Jan E, Brummelkamp, Thijn R, Clish, Clary B, Sabatini, David M
Published in Nature genetics (01.01.2013)
Published in Nature genetics (01.01.2013)
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STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
Ding, Siyuan, Diep, Jonathan, Feng, Ningguo, Ren, Lili, Li, Bin, Ooi, Yaw Shin, Wang, Xin, Brulois, Kevin F., Yasukawa, Linda L., Li, Xingnan, Kuo, Calvin J., Solomon, David A., Carette, Jan E., Greenberg, Harry B.
Published in Nature communications (16.04.2018)
Published in Nature communications (16.04.2018)
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