PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
Milioto, Carmelo, Carcolé, Mireia, Giblin, Ashling, Coneys, Rachel, Attrebi, Olivia, Ahmed, Mhoriam, Harris, Samuel S, Lee, Byung Il, Yang, Mengke, Ellingford, Robert A, Nirujogi, Raja S, Biggs, Daniel, Salomonsson, Sally, Zanovello, Matteo, de Oliveira, Paula, Katona, Eszter, Glaria, Idoia, Mikheenko, Alla, Geary, Bethany, Udine, Evan, Vaizoglu, Deniz, Anoar, Sharifah, Jotangiya, Khrisha, Crowley, Gerard, Smeeth, Demelza M, Adams, Mirjam L, Niccoli, Teresa, Rademakers, Rosa, van Blitterswijk, Marka, Devoy, Anny, Hong, Soyon, Partridge, Linda, Coyne, Alyssa N, Fratta, Pietro, Alessi, Dario R, Davies, Ben, Busche, Marc Aurel, Greensmith, Linda, Fisher, Elizabeth M C, Isaacs, Adrian M
Published in Nature neuroscience (01.04.2024)
Published in Nature neuroscience (01.04.2024)
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Journal Article
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids
van der Geest, Astrid T, Jakobs, Channa E, Ljubikj, Tijana, Huffels, Christiaan F. M, Caéizares Luna, Marta, Vieira de Sá, Renata, Adolfs, Youri, de Wit, Marina, Rutten, Daan H, Kaal, Marthe, Zwartkruis, Maria M, Carcolé, Mireia, Groen, Ewout J. N, Hol, Elly M, Basak, Onur, Isaacs, Adrian M, Westeneng, Henk-Jan, van den Berg, Leonard H, Veldink, Jan H, Schlegel, Domino K, Pasterkamp, R. Jeroen
Published in Acta neuropathologica communications (18.09.2024)
Published in Acta neuropathologica communications (18.09.2024)
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Journal Article
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
Vahsen, Björn F, Nalluru, Sumedha, Morgan, Georgia R, Farrimond, Lucy, Carroll, Emily, Xu, Yinyan, Cramb, Kaitlyn M L, Amein, Benazir, Scaber, Jakub, Katsikoudi, Antigoni, Candalija, Ana, Carcolé, Mireia, Dafinca, Ruxandra, Isaacs, Adrian M, Wade-Martins, Richard, Gray, Elizabeth, Turner, Martin R, Cowley, Sally A, Talbot, Kevin
Published in Nature communications (22.09.2023)
Published in Nature communications (22.09.2023)
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Journal Article
Treatment with a heme oxygenase 1 inducer enhances the antinociceptive effects of µ-opioid, δ-opioid, and cannabinoid 2 receptors during inflammatory pain
Carcolé, Mireia, Castany, Sílvia, Leánez, Sergi, Pol, Olga
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
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Journal Article
Sigma‐1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain
Carcolé, Mireia, Kummer, Sami, Gonçalves, Leonor, Zamanillo, Daniel, Merlos, Manuel, Dickenson, Anthony H., Fernández‐Pastor, Begoña, Cabañero, David, Maldonado, Rafael
Published in British journal of pharmacology (01.10.2019)
Published in British journal of pharmacology (01.10.2019)
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Journal Article
Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain
Carcolé, Mireia, Zamanillo, Daniel, Merlos, Manuel, Fernández-Pastor, Begoña, Cabañero, David, Maldonado, Rafael
Published in Frontiers in pharmacology (2019)
Published in Frontiers in pharmacology (2019)
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Journal Article
Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons
Scaber, Jakub, Thomas-Wright, Iona, Clark, Alex J., Xu, Yinyan, Vahsen, Björn F., Carcolé, Mireia, Dafinca, Ruxandra, Farrimond, Lucy, Isaacs, Adrian M., Bennett, David L., Talbot, Kevin
Published in Stem cell reports (09.07.2024)
Published in Stem cell reports (09.07.2024)
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Journal Article
Toxicity of C9orf72 -associated dipeptide repeat peptides is modified by commonly used protein tags
Morón-Oset, Javier, Fischer, Lilly Ks, Carcolé, Mireia, Giblin, Ashling, Zhang, Pingze, Isaacs, Adrian M, Grönke, Sebastian, Partridge, Linda
Published in Life science alliance (01.09.2023)
Published in Life science alliance (01.09.2023)
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Journal Article
Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Wilson, Katherine M, Glaria, Idoia, Swift, Imogen J, Heller, Carolin, Bouzigues, Arabella, Heslegrave, Amanda J, Keshavan, Ashvini, Knowles, Kathryn, Patil, Saurabh, Mohapatra, Susovan, Liu, Yuanjing, Goyal, Jaya, Sanchez-Valle, Raquel, Finger, Elizabeth, Vandenberghe, Rik, Seelaar, Harro, Borroni, Barbara, de Mendonça, Alexandre, Otto, Markus, Ducharme, Simon, Schott, Jonathan M, Isaacs, Adrian M, Afonso, Sónia, Anderl-Straub, Sarah, Antonell, Anna, Archetti, Silvana, Balasa, Mircea, Barandiaran, Myriam, Bargalló, Nuria, Bartha, Robart, Bender, Benjamin, Bertoux, Maxime, Bertrand, Anne, Black, Sandra, Bocchetta, Martina, Borrego-Ecija, Sergi, Bras, Jose, Brice, Alexis, Bruffaerts, Rose, Camuzat, Agnès, Cash, David, Castelo-Branco, Miguel, Danek, Adrian, Deramecourt, Vincent, Díez, Alina, Duro, Diana, Fenoglio, Chiara, Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, Funkiewiez, Aurélie, Gazzina, Stefano, Gorostidi, Ana, Graf, Lisa, Greaves, Caroline, Hoegen, Tobias, Jelic, Vesna, Keren, Ron, Langheinrich, Tobias, Ber, Isabelle Le, Lebouvier, Thibaud, Levin, Johannes, Lladó, Albert, Lombardi, Jolina, Loosli, Sandra, Mead, Simon, Minkelen, Rick van, Mitchell, Sara, Nacmias, Benedetta, Nelson, Annabel, Papma, Janne M., Pasquier, Florence, Peakman, Georgia, Pijnenburg, Yolande, Polito, Cristina, Premi, Enrico, Redaelli, Veronica, Rinaldi, Daisy, Rogaeva, Ekaterina, Santana, Isabel, Saracino, Dario, Scarpini, Elio, Schönecker, Sonja, Shafei, Rachelle, Shoesmith, Christen, Sorbi, Sandro, Tábuas-Pereira, Miguel, Tagliavini, Fabrizio, Tainta, Mikel, Taipa, Ricardo, Tang-Wai, David, Thomas, David L, Thompson, Paul, Todd, Emily, Damme, Philip Van, Vandenbulcke, Mathieu, Verdelho, Ana, Warren, Jason, Wilke, Carlo, Wlasich, Elisabeth
Published in Journal of neurology, neurosurgery and psychiatry (01.07.2022)
Published in Journal of neurology, neurosurgery and psychiatry (01.07.2022)
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Journal Article
Neuronal polyunsaturated fatty acids are protective in FTD/ALS
Giblin, Ashling, Cammack, Alexander J, Blomberg, Niek, Mikheenko, Alla, Carcole, Mireia, Coneys, Rachel, Zhou, Lele, Yassene Mohammed, Olivier-Jimenez, Damien, Atilano, Magda L, Niccoli, Teresa, Coyne, Alyssa N, Van Der Kant, Rik, Lashley, Tammaryn, Giera, Martin, Partridge, Linda, Isaacs, Adrian M
Published in bioRxiv (17.01.2024)
Published in bioRxiv (17.01.2024)
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Paper
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo
Kempthorne, Liam, Vaizoglu, Deniz, Cammack, Alexander J, Carcole, Mireia, Suklai, Pacharaporn, Muralidharan, Bhavana, Kroll, Francois, Moens, Thomas G, Yshii, Lidia, Verschoren, Stijn, Holbling, Benedikt V, Katona, Eszter, Mikheenko, Alla, Coneys, Rachel, De Oliveira, Paula, Yong-Jie, Zhang, Jensen, Karen, Daughrity, Lillian M, Mcgown, Alexander, Ramesh, Tennore M, Van Den Bosch, Ludo, Rahim, Ahad A, Petrucelli, Leonard, Rihel, Jason, Isaacs, Adrian M
Published in bioRxiv (28.01.2024)
Published in bioRxiv (28.01.2024)
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Paper
USE OF (R)-9-(2,5-DIFLUOROPHENETHYL)-4-ETHYL-2-METHYL-1-OXA-4,9-DIAZASPIRO[5.5]UNDECAN-3-ONE FOR THE TREATMENT OF NOCICEPTIVE PAIN, NEUROPATHIC PAIN, OSTEOARTHRITIS PAIN AND CANCER PAIN, WHILE HAVING REDUCED SIDE EFFECTS COMPARED TO OPIOIDS
VIDAL-TORRES, Alba, VELA-HERNANDEZ, Jose-Miguel, MALDONADO-LOPEZ, Rafael, MERLOS ROCA, Manuel, ZAMANILLO CASTANEDO, Daniel, CARCOLE-ESTRADA, Mireia, FERNANDEZ-PASTOR, Begoña
Year of Publication 04.02.2021
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Year of Publication 04.02.2021
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