Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry
Cappell, Steven D, Chung, Mingyu, Jaimovich, Ariel, Spencer, Sabrina L, Meyer, Tobias
Published in Cell (30.06.2016)
Published in Cell (30.06.2016)
Get full text
Journal Article
Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
Chung, Mingyu, Liu, Chad, Yang, Hee Won, Köberlin, Marielle S., Cappell, Steven D., Meyer, Tobias
Published in Molecular cell (21.11.2019)
Published in Molecular cell (21.11.2019)
Get full text
Journal Article
Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation
Akef, Abdalla, McGraw, Kathy, Cappell, Steven D, Larson, Daniel R
Published in PLoS biology (01.11.2020)
Published in PLoS biology (01.11.2020)
Get full text
Journal Article
Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor
Paul, Debasish, Kales, Stephen C., Cornwell, James A., Afifi, Marwa M., Rai, Ganesha, Zakharov, Alexey, Simeonov, Anton, Cappell, Steven D.
Published in Nature communications (26.10.2022)
Published in Nature communications (26.10.2022)
Get full text
Journal Article
Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation
Yang, Hee Won, Cappell, Steven D, Jaimovich, Ariel, Liu, Chad, Chung, Mingyu, Daigh, Leighton H, Pack, Lindsey R, Fan, Yilin, Regot, Sergi, Covert, Markus, Meyer, Tobias
Published in eLife (07.04.2020)
Published in eLife (07.04.2020)
Get full text
Journal Article
Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
Afifi, Marwa M., Crncec, Adrijana, Cornwell, James A., Cataisson, Christophe, Paul, Debasish, Ghorab, Laila M., Hernandez, Maria O., Wong, Madeline, Kedei, Noemi, Cappell, Steven D.
Published in Cell reports (Cambridge) (26.09.2023)
Published in Cell reports (Cambridge) (26.09.2023)
Get full text
Journal Article
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response
Amin, Ruhul, Shukla, Anjali, Zhu, Jacqueline Jufen, Kim, Sohyoung, Wang, Ping, Tian, Simon Zhongyuan, Tran, Andy D., Paul, Debasish, Cappell, Steven D., Burkett, Sandra, Liu, Huaitian, Lee, Maxwell P., Kruhlak, Michael J., Dwyer, Jennifer E., Simpson, R. Mark, Hager, Gordon L., Ruan, Yijun, Hunter, Kent W.
Published in Nature communications (13.12.2021)
Published in Nature communications (13.12.2021)
Get full text
Journal Article
The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
Jang, Sang-Min, Nathans, Jenny F., Fu, Haiqing, Redon, Christophe E., Jenkins, Lisa M., Thakur, Bhushan L., Pongor, Lőrinc S., Baris, Adrian M., Gross, Jacob M., OʹNeill, Maura J., Indig, Fred E., Cappell, Steven D., Aladjem, Mirit I.
Published in Nature communications (07.01.2020)
Published in Nature communications (07.01.2020)
Get full text
Journal Article
EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle
Cappell, Steven D., Mark, Kevin G., Garbett, Damien, Pack, Lindsey R., Rape, Michael, Meyer, Tobias
Published in Nature (London) (01.06.2018)
Published in Nature (London) (01.06.2018)
Get full text
Journal Article
Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Lambert, Nevin A, Johnston, Christopher A, Cappell, Steven D, Kuravi, Sudhakiranmayi, Kimple, Adam J, Willard, Francis S, Siderovski, David P
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2010)
Get full text
Journal Article
Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal
Cornwell, James A., Crncec, Adrijana, Afifi, Marwa M., Tang, Kristina, Amin, Ruhul, Cappell, Steven D.
Published in Nature (London) (13.07.2023)
Published in Nature (London) (13.07.2023)
Get full text
Journal Article
EMI1 switches from being a substrate to an inhibitor of APC/C CDH1 to start the cell cycle
Cappell, Steven D, Mark, Kevin G, Garbett, Damien, Pack, Lindsey R, Rape, Michael, Meyer, Tobias
Published in Nature (London) (14.06.2018)
Published in Nature (London) (14.06.2018)
Get full text
Journal Article
Author Correction: Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal
Cornwell, James A., Crncec, Adrijana, Afifi, Marwa M., Tang, Kristina, Amin, Ruhul, Cappell, Steven D.
Published in Nature (London) (27.06.2024)
Published in Nature (London) (27.06.2024)
Get full text
Journal Article
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR
Zong, Dali, Koussa, Natasha C, Cornwell, James A, Pankajam, Ajith V, Kruhlak, Michael J, Wong, Nancy, Chari, Raj, Cappell, Steven D, Nussenzweig, André
Published in Genes & development (01.10.2023)
Published in Genes & development (01.10.2023)
Get full text
Journal Article
The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity
Awadia, Sahezeel, Sitto, Merna, Ram, Sundaresh, Ji, Wenbin, Liu, Yajing, Damani, Raheema, Ray, Dipankar, Lawrence, Theodore S., Galban, Craig J., Cappell, Steven D., Rehemtulla, Alnawaz
Published in The Journal of biological chemistry (01.06.2023)
Published in The Journal of biological chemistry (01.06.2023)
Get full text
Journal Article
Abrogation of the G2/M checkpoint as a chemosensitization approach for alkylating agents
Lang, Fengchao, Cornwell, James A, Kaur, Karambir, Elmogazy, Omar, Zhang, Wei, Zhang, Meili, Song, Hua, Sun, Zhonghe, Wu, Xiaolin, Aladjem, Mirit I, Aregger, Michael, Cappell, Steven D, Yang, Chunzhang
Published in Neuro-oncology (Charlottesville, Va.) (03.06.2024)
Published in Neuro-oncology (Charlottesville, Va.) (03.06.2024)
Get full text
Journal Article
Cell cycle inertia underlies a bifurcation in cell fates after DNA damage
Nathans, Jenny F, Cornwell, James A, Afifi, Marwa M, Paul, Debasish, Cappell, Steven D
Published in Science advances (01.01.2021)
Published in Science advances (01.01.2021)
Get full text
Journal Article
Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway
Park, Woo-Yong, Gray, Justin M, Holewinski, Ronald J, Andresson, Thorkell, So, Jae Young, Carmona-Rivera, Carmelo, Hollander, M Christine, Yang, Howard H, Lee, Maxwell, Kaplan, Mariana J, Cappell, Steven D, Yang, Li
Published in Nature cancer (01.03.2023)
Published in Nature cancer (01.03.2023)
Get more information
Journal Article