Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If : Novel electrophysiological insights and therapeutic potential
Capel, Rebecca A., DPhil, Herring, Neil, DPhil, MRCP, Kalla, Manish, BSc (Hons), MBBS MRCP, Yavari, Arash, BSc (Hons), MBBS, MRCP, DPhil, Mirams, Gary R., PhD, Douglas, Gillian, PhD, Bub, Gil, PhD, Channon, Keith, MD, FRCP, FMedSci, Paterson, David J., DPhil, DSc, Terrar, Derek A., PhD, Burton, Rebecca-Ann B., MSc, MBA, DPhil
Published in Heart rhythm (01.10.2015)
Published in Heart rhythm (01.10.2015)
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Journal Article
IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases
Capel, Rebecca A, Bose, Samuel J, Collins, Thomas P, Rajasundaram, Skanda, Ayagama, Thamali, Zaccolo, Manuela, Burton, Rebecca-Ann Beatrice, Terrar, Derek A
Published in American journal of physiology. Heart and circulatory physiology (01.01.2021)
Published in American journal of physiology. Heart and circulatory physiology (01.01.2021)
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Journal Article
Lysosomal calcium loading promotes spontaneous calcium release by potentiating ryanodine receptors
Meng, Zhaozheng, Capel, Rebecca A., Bose, Samuel J., Bosch, Erik, de Jong, Sophia, Planque, Robert, Galione, Antony, Burton, Rebecca A.B., Bueno-Orovio, Alfonso
Published in Biophysical journal (08.08.2023)
Published in Biophysical journal (08.08.2023)
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Journal Article
Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP
Akerman, Emily C, Read, Matthew J, Bose, Samuel J, Koschinski, Andreas, Capel, Rebecca A, Chao, Ying-Chi, Folkmanaite, Milda, Ayagama, Thamali, Broadbent, Steven D, Ahamed, Rufaida, Simon, Jillian N, Terrar, Derek A, Zaccolo, Manuela, Burton, Rebecca-Ann A B
Published in American journal of physiology. Heart and circulatory physiology (02.08.2024)
Published in American journal of physiology. Heart and circulatory physiology (02.08.2024)
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Journal Article
Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca2+ transients in murine heart
Wen, Q., Gandhi, K., Capel, Rebecca A., Hao, G., O'Shea, C., Neagu, G., Pearcey, S., Pavlovic, D., Terrar, Derek A., Wu, J., Faggian, G., Camelliti, Patrizia, Lei, M.
Published in The Journal of physiology (01.09.2018)
Published in The Journal of physiology (01.09.2018)
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Journal Article
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart
Capel, Rebecca A., Bolton, Emma L., Lin, Wee K., Aston, Daniel, Wang, Yanwen, Liu, Wei, Wang, Xin, Burton, Rebecca-Ann B., Bloor-Young, Duncan, Shade, Kai-Ting, Ruas, Margarida, Parrington, John, Churchill, Grant C., Lei, Ming, Galione, Antony, Terrar, Derek A.
Published in The Journal of biological chemistry (11.12.2015)
Published in The Journal of biological chemistry (11.12.2015)
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Journal Article
High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart
Aston, Daniel, Capel, Rebecca A., Ford, Kerrie L., Christian, Helen C., Mirams, Gary R., Rog-Zielinska, Eva A., Kohl, Peter, Galione, Antony, Burton, Rebecca A. B., Terrar, Derek A.
Published in Scientific reports (17.01.2017)
Published in Scientific reports (17.01.2017)
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Journal Article
IP 3 -mediated Ca 2+ release regulates atrial Ca 2+ transients and pacemaker function by stimulation of adenylyl cyclases
Capel, Rebecca A, Bose, Samuel J, Collins, Thomas P, Rajasundaram, Skanda, Ayagama, Thamali, Zaccolo, Manuela, Burton, Rebecca-Ann Beatrice, Terrar, Derek A
Published in American journal of physiology. Heart and circulatory physiology (01.01.2021)
Published in American journal of physiology. Heart and circulatory physiology (01.01.2021)
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Journal Article
Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate
Bose, Samuel J., Read, Matthew J., Akerman, Emily, Capel, Rebecca A., Ayagama, Thamali, Russell, Angela, Terrar, Derek A., Zaccolo, Manuela, Burton, Rebecca A. B.
Published in Frontiers in pharmacology (29.08.2022)
Published in Frontiers in pharmacology (29.08.2022)
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Journal Article
Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies
Chan, Xin Hui S., Chotsiri, Palang, Capel, Rebecca A., Pike, James, Hanboonkunupakarn, Borimas, Lee, Sue J., Hanafiah, Maryam, Win, Yan Naung, Cremer, Maegan A., Kiechel, Jean‐René, Ogutu, Bernhards, Taylor, Walter R. J., Burton, Rebecca‐Ann B., Tarning, Joel, White, Nicholas J.
Published in British journal of clinical pharmacology (01.03.2023)
Published in British journal of clinical pharmacology (01.03.2023)
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Journal Article
Load-dependent effects of apelin on murine cardiomyocytes
Peyronnet, Rémi, Bollensdorff, Christian, Capel, Rebecca A., Rog-Zielinska, Eva A., Woods, Christopher E., Charo, David N., Lookin, Oleg, Fajardo, Giovanni, Ho, Michael, Quertermous, Thomas, Ashley, Euan A., Kohl, Peter
Published in Progress in biophysics and molecular biology (01.11.2017)
Published in Progress in biophysics and molecular biology (01.11.2017)
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Journal Article
Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine
Whittaker, Dominic G, Capel, Rebecca A, Hendrix, Maurice, Chan, Xin Hui S, Herring, Neil, White, Nicholas J, Mirams, Gary R, Burton, Rebecca-Ann B
Published in Royal Society open science (13.04.2021)
Published in Royal Society open science (13.04.2021)
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Journal Article
Mapping cardiac microstructure of rabbit heart in different mechanical states by high resolution diffusion tensor imaging: A proof-of-principle study
Teh, Irvin, Burton, Rebecca A.B., McClymont, Darryl, Capel, Rebecca A., Aston, Daniel, Kohl, Peter, Schneider, Jürgen E.
Published in Progress in biophysics and molecular biology (01.07.2016)
Published in Progress in biophysics and molecular biology (01.07.2016)
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Journal Article
Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation
Ayagama, Thamali, Charles, Philip D., Bose, Samuel J., Boland, Barry, Priestman, David A., Aston, Daniel, Berridge, Georgina, Fischer, Roman, Cribbs, Adam P., Song, Qianqian, Mirams, Gary R., Amponsah, Kwabena, Heather, Lisa, Galione, Antony, Herring, Neil, Kramer, Holger, Capel, Rebecca A., Platt, Frances M., Schotten, Ulrich, Verheule, Sander, Burton, Rebecca A.B.
Published in iScience (21.06.2024)
Published in iScience (21.06.2024)
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Journal Article
Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca 2+ transients in murine heart
Wen, Q, Gandhi, K, Capel, Rebecca A, Hao, G, O'Shea, C, Neagu, G, Pearcey, S, Pavlovic, D, Terrar, Derek A, Wu, J, Faggian, G, Camelliti, Patrizia, Lei, M
Published in The Journal of physiology (01.09.2018)
Published in The Journal of physiology (01.09.2018)
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Journal Article
A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue
Ayagama, Thamali, Bose, Samuel J., Capel, Rebecca A., Priestman, David A., Berridge, Georgina, Fischer, Roman, Galione, Antony, Platt, Frances M., Kramer, Holger, Burton, Rebecca A.B.
Published in iScience (24.09.2021)
Published in iScience (24.09.2021)
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Journal Article
Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics
Burton, Rebecca-Ann B., Tomek, Jakub, Ambrosi, Christina M., Larsen, Hege E., Sharkey, Amy R., Capel, Rebecca A., Corbett, Alexander D., Bilton, Samuel, Klimas, Aleksandra, Stephens, Guy, Cremer, Maegan, Bose, Samuel J., Li, Dan, Gallone, Giuseppe, Herring, Neil, Mann, Edward O., Kumar, Abhinav, Kramer, Holger, Entcheva, Emilia, Paterson, David J., Bub, Gil
Published in iScience (24.07.2020)
Published in iScience (24.07.2020)
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Journal Article