Combining Antivirals and Immunomodulators to Fight COVID-19
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Shannon, Ashleigh, Selisko, Barbara, Le, Nhung-Thi-Tuyet, Huchting, Johanna, Touret, Franck, Piorkowski, Géraldine, Fattorini, Véronique, Ferron, François, Decroly, Etienne, Meier, Chris, Coutard, Bruno, Peersen, Olve, Canard, Bruno
Published in Nature communications (17.09.2020)
Published in Nature communications (17.09.2020)
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Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA
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Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2018)
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RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex
Bouvet, Mickaël, Imbert, Isabelle, Subissi, Lorenzo, Gluais, Laure, Canard, Bruno, Decroly, Etienne
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Shannon, Ashleigh, Fattorini, Véronique, Sama, Bhawna, Selisko, Barbara, Feracci, Mikael, Falcou, Camille, Gauffre, Pierre, El Kazzi, Priscila, Delpal, Adrien, Decroly, Etienne, Alvarez, Karine, Eydoux, Cécilia, Guillemot, Jean-Claude, Moussa, Adel, Good, Steven S., La Colla, Paolo, Lin, Kai, Sommadossi, Jean-Pierre, Zhu, Yingxiao, Yan, Xiaodong, Shi, Hui, Ferron, François, Canard, Bruno
Published in Nature communications (02.02.2022)
Published in Nature communications (02.02.2022)
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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
Subissi, Lorenzo, Posthuma, Clara C, Collet, Axelle, Zevenhoven-Dobbe, Jessika C, Gorbalenya, Alexander E, Decroly, Etienne, Snijder, Eric J, Canard, Bruno, Imbert, Isabelle
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
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Snapshots of ADP-ribose bound to Getah virus macro domain reveal an intriguing choreography
Ferreira-Ramos, Ana Sofia, Sulzenbacher, Gerlind, Canard, Bruno, Coutard, Bruno
Published in Scientific reports (02.09.2020)
Published in Scientific reports (02.09.2020)
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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective
Seifert, Mona, Bera, Subhas C, van Nies, Pauline, Kirchdoerfer, Robert N, Shannon, Ashleigh, Le, Thi-Tuyet-Nhung, Meng, Xiangzhi, Xia, Hongjie, Wood, James M, Harris, Lawrence D, Papini, Flavia S, Arnold, Jamie J, Almo, Steven, Grove, Tyler L, Shi, Pei-Yong, Xiang, Yan, Canard, Bruno, Depken, Martin, Cameron, Craig E, Dulin, David
Published in eLife (07.10.2021)
Published in eLife (07.10.2021)
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In vitro reconstitution of SARS-coronavirus mRNA cap methylation
Bouvet, Mickaël, Debarnot, Claire, Imbert, Isabelle, Selisko, Barbara, Snijder, Eric J, Canard, Bruno, Decroly, Etienne
Published in PLoS pathogens (01.04.2010)
Published in PLoS pathogens (01.04.2010)
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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
Lahouassa, Hichem, Daddacha, Waaqo, Hofmann, Henning, Ayinde, Diana, Logue, Eric C, Dragin, Loïc, Bloch, Nicolin, Maudet, Claire, Bertrand, Matthieu, Gramberg, Thomas, Pancino, Gianfranco, Priet, Stéphane, Canard, Bruno, Laguette, Nadine, Benkirane, Monsef, Transy, Catherine, Landau, Nathaniel R, Kim, Baek, Margottin-Goguet, Florence
Published in Nature immunology (01.03.2012)
Published in Nature immunology (01.03.2012)
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The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain
Potisopon, Supanee, Priet, Stéphane, Collet, Axelle, Decroly, Etienne, Canard, Bruno, Selisko, Barbara
Published in Nucleic Acids Research (13.10.2014)
Published in Nucleic Acids Research (13.10.2014)
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Regulation of Flavivirus RNA synthesis and replication
Selisko, Barbara, Wang, Chunling, Harris, Eva, Canard, Bruno
Published in Current opinion in virology (01.12.2014)
Published in Current opinion in virology (01.12.2014)
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Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex
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Published in PLoS pathogens (01.05.2011)
Published in PLoS pathogens (01.05.2011)
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Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes
Bouvet, Mickaël, Lugari, Adrien, Posthuma, Clara C., Zevenhoven, Jessika C., Bernard, Stéphanie, Betzi, Stéphane, Imbert, Isabelle, Canard, Bruno, Guillemot, Jean-Claude, Lécine, Patrick, Pfefferle, Susanne, Drosten, Christian, Snijder, Eric J., Decroly, Etienne, Morelli, Xavier
Published in The Journal of biological chemistry (12.09.2014)
Published in The Journal of biological chemistry (12.09.2014)
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The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution
Chazot, Aurélie, Zimberger, Claire, Feracci, Mikael, Moussa, Adel, Good, Steven, Sommadossi, Jean-Pierre, Alvarez, Karine, Ferron, François, Canard, Bruno
Published in PLoS biology (27.08.2024)
Published in PLoS biology (27.08.2024)
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Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase
Abdelnabi, Rana, Morais, Ana Theresa Silveira de, Leyssen, Pieter, Imbert, Isabelle, Beaucourt, Stéphanie, Blanc, Hervé, Froeyen, Mathy, Vignuzzi, Marco, Canard, Bruno, Neyts, Johan, Delang, Leen
Published in Journal of virology (15.06.2017)
Published in Journal of virology (15.06.2017)
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