IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
Lückel, Christina, Picard, Felix, Raifer, Hartmann, Campos Carrascosa, Lucia, Guralnik, Anna, Zhang, Yajuan, Klein, Matthias, Bittner, Stefan, Steffen, Falk, Moos, Sonja, Marini, Federico, Gloury, Renee, Kurschus, Florian C., Chao, Ying-Yin, Bertrams, Wilhelm, Sexl, Veronika, Schmeck, Bernd, Bonetti, Lynn, Grusdat, Melanie, Lohoff, Michael, Zielinski, Christina E., Zipp, Frauke, Kallies, Axel, Brenner, Dirk, Berger, Michael, Bopp, Tobias, Tackenberg, Björn, Huber, Magdalena
Published in Nature communications (16.12.2019)
Published in Nature communications (16.12.2019)
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Journal Article
Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules
Zhou, Guoying, Sprengers, Dave, Mancham, Shanta, Erkens, Remco, Boor, Patrick P.C., van Beek, Adriaan A., Doukas, Michail, Noordam, Lisanne, Campos Carrascosa, Lucia, de Ruiter, Valeska, van Leeuwen, Roelof W.F., Polak, Wojciech G., de Jonge, Jeroen, Groot Koerkamp, Bas, van Rosmalen, Belle, van Gulik, Thomas M., Verheij, Joanne, IJzermans, Jan N.M., Bruno, Marco J., Kwekkeboom, Jaap
Published in Journal of hepatology (01.10.2019)
Published in Journal of hepatology (01.10.2019)
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Journal Article
GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma
Beek, Adriaan A., Zhou, Guoying, Doukas, Michail, Boor, Patrick P.C., Noordam, Lisanne, Mancham, Shanta, Campos Carrascosa, Lucia, Heide‐Mulder, Marieke, Polak, Wojciech G., Ijzermans, Jan N.M., Pan, Qiuwei, Heirman, Carlo, Mahne, Ashley, Bucktrout, Samantha L., Bruno, Marco J., Sprengers, Dave, Kwekkeboom, Jaap
Published in International journal of cancer (15.08.2019)
Published in International journal of cancer (15.08.2019)
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Journal Article
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
Campos Carrascosa, Lucia, Klein, Matthias, Kitagawa, Yohko, Lückel, Christina, Marini, Federico, König, Anika, Guralnik, Anna, Raifer, Hartmann, Hagner-Benes, Stefanie, Rädler, Diana, Böck, Andreas, Kang, Cholho, Lohoff, Michael, Garn, Holger, Schaub, Bianca, Berberich-Siebelt, Friederike, Sakaguchi, Shimon, Bopp, Tobias, Huber, Magdalena
Published in Nature communications (12.05.2017)
Published in Nature communications (12.05.2017)
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An engineered T-cell engager with selectivity for high mesothelin-expressing cells and activity in the presence of soluble mesothelin
Snell, Daniel, Gunde, Tea, Warmuth, Stefan, Chatterjee, Bithi, Brock, Matthias, Hess, Christian, Johansson, Maria, Simonin, Alexandre, Spiga, Fabio Mario, Weinert, Christopher, Kirk, Niels, Bassler, Nicole, Campos Carrascosa, Lucia, Flückiger, Naomi, Heiz, Robin, Wagen, Sandro, Giezendanner, Noreen, Alberti, Alessandra, Yaman, Yasemin, Mahler, Dana, Diem, Dania, Lichtlen, Peter, Urech, David
Published in Oncoimmunology (31.12.2023)
Published in Oncoimmunology (31.12.2023)
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Journal Article
Expression of Cancer Testis Antigens in Tumor-Adjacent Normal Liver Is Associated with Post-Resection Recurrence of Hepatocellular Carcinoma
Noordam, Lisanne, Ge, Zhouhong, Özturk, Hadiye, Doukas, Michail, Mancham, Shanta, Boor, Patrick P. C., Campos Carrascosa, Lucia, Zhou, Guoying, van den Bosch, Thierry P. P., Pan, Qiuwei, IJzermans, Jan N. M., Bruno, Marco J., Sprengers, Dave, Kwekkeboom, Jaap
Published in Cancers (20.05.2021)
Published in Cancers (20.05.2021)
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Journal Article
FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells
Campos Carrascosa, Lucia, van Beek, Adriaan A, de Ruiter, Valeska, Doukas, Michail, Wei, Jie, Fisher, Timothy S, Ching, Keith, Yang, Wenjing, van Loon, Karlijn, Boor, Patrick P C, Rakké, Yannick S, Noordam, Lisanne, Doornebosch, Pascal, Grünhagen, Dirk, Verhoef, Kees, Polak, Wojciech G, IJzermans, Jan N M, Ni, Irene, Yeung, Yik Andy, Salek-Ardakani, Shahram, Sprengers, Dave, Kwekkeboom, Jaap
Published in Journal for immunotherapy of cancer (01.09.2020)
Published in Journal for immunotherapy of cancer (01.09.2020)
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Journal Article
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
Luu, Maik, Pautz, Sabine, Kohl, Vanessa, Singh, Rajeev, Romero, Rossana, Lucas, Sébastien, Hofmann, Jörg, Raifer, Hartmann, Vachharajani, Niyati, Carrascosa, Lucia Campos, Lamp, Boris, Nist, Andrea, Stiewe, Thorsten, Shaul, Yoav, Adhikary, Till, Zaiss, Mario M., Lauth, Matthias, Steinhoff, Ulrich, Visekruna, Alexander
Published in Nature communications (15.02.2019)
Published in Nature communications (15.02.2019)
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Journal Article
TIGIT and PD1 Co-blockade Restores ex vivo Functions of Human Tumor-Infiltrating CD8+ T Cells in Hepatocellular Carcinoma
Ge, Zhouhong, Zhou, Guoying, Campos Carrascosa, Lucia, Gausvik, Erik, Boor, Patrick P.C., Noordam, Lisanne, Doukas, Michael, Polak, Wojciech G., Terkivatan, Türkan, Pan, Qiuwei, Takkenberg, R. Bart, Verheij, Joanne, Erdmann, Joris I., IJzermans, Jan N.M., Peppelenbosch, Maikel P., Kraan, Jaco, Kwekkeboom, Jaap, Sprengers, Dave
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
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Journal Article
1389 An assessment of ROR1 expression across tumor tissue and the investigation of a ROR1-targeted T cell engager as a therapeutic strategy to target ROR1 positive tumors
Snell, Daniel, Kirk, Niels, Bassler, Nicole, Carrascosa, Lucia Campos, Chrom, Pawel, Lichtlen, Peter, Urech, David
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells
Rakké, Yannick S., Campos Carrascosa, Lucia, van Beek, Adriaan A., de Ruiter, Valeska, van Gemerden, Rachelle S., Doukas, Michail, Doornebosch, Pascal G., Vermaas, Maarten, ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L.O., Kliffen, Mike, Grünhagen, Dirk J., Verhoef, Cornelis, IJzermans, Jan N.M., Kwekkeboom, Jaap, Sprengers, Dave
Published in Cellular and molecular gastroenterology and hepatology (01.01.2023)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2023)
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Journal Article
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance
Liu, Jiaye, Li, Pengfei, Wang, Ling, Li, Meng, Ge, Zhouhong, Noordam, Lisanne, Lieshout, Ruby, Verstegen, Monique M.A., Ma, Buyun, Su, Junhong, Yang, Qin, Zhang, Ruyi, Zhou, Guoying, Carrascosa, Lucia Campos, Sprengers, Dave, IJzermans, Jan N.M., Smits, Ron, Kwekkeboom, Jaap, van der Laan, Luc J.W., Peppelenbosch, Maikel P., Pan, Qiuwei, Cao, Wanlu
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
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Journal Article
Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
Zhou, Guoying, Lieshout, Ruby, van Tienderen, Gilles S., de Ruiter, Valeska, van Royen, Martin E., Boor, Patrick P. C., Magré, Luc, Desai, Jyaysi, Köten, Kübra, Kan, Yik Yang, Ge, Zhouhong, Campos Carrascosa, Lucia, Geuijen, Cecile, Sprengers, Dave, van der Laan, Luc J. W., Verstegen, Monique M. A., Kwekkeboom, Jaap
Published in British journal of cancer (01.09.2022)
Published in British journal of cancer (01.09.2022)
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Journal Article
TIGIT and PD1 dual checkpoint blockade restores functionality of tumor-infiltrating T cells in hepatocellular carcinoma
Ge, Zhouhong, Zhou, Guoying, Carrascosa, Lucia Campos, Gausvik, Erik, Boor, Patrick, Noordam, Lisanne, Pan, Qiuwei, Verheij, Joanne, Erdmann, Joris, Doukas, Michael, IJzermans, Jan, Kraan, Jaco, Peppelenbosch, Maikel, Kwekkeboom, Jaap, Sprengers, Dave
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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Journal Article
FRI484 - TIGIT and PD1 dual checkpoint blockade restores functionality of tumor-infiltrating T cells in hepatocellular carcinoma
Ge, Zhouhong, Zhou, Guoying, Carrascosa, Lucia Campos, Gausvik, Erik, Boor, Patrick, Noordam, Lisanne, Pan, Qiuwei, Verheij, Joanne, Erdmann, Joris, Doukas, Michael, IJzermans, Jan, Kraan, Jaco, Peppelenbosch, Maikel, Kwekkeboom, Jaap, Sprengers, Dave
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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Journal Article
An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity
Xu, Yuanming, Carrascosa, Lucia Campos, Yeung, Yik Andy, Chu, Matthew Ling-Hon, Yang, Wenjing, Djuretic, Ivana, Pappas, Danielle C, Zeytounian, John, Ge, Zhouhong, de Ruiter, Valeska, Starbeck-Miller, Gabriel R, Patterson, James, Rigas, Diamanda, Chen, Shih-Hsun, Kraynov, Eugenia, Boor, Patrick P, Noordam, Lisanne, Doukas, Michael, Tsao, Dave, Ijzermans, Jan N, Guo, Jie, Grünhagen, Dirk J, Erdmann, Joris, Verheij, Joanne, van Royen, Martin E, Doornebosch, Pascal G, Feldman, Renny, Park, Terrence, Mahmoudi, Salah, Dorywalska, Magdalena, Ni, Irene, Chin, Sherman M, Mistry, Tina, Mosyak, Lidia, Lin, Laura, Ching, Keith A, Lindquist, Kevin C, Ji, Changhua, Londono, Luz Marina, Kuang, Bing, Rickert, Robert, Kwekkeboom, Jaap, Sprengers, Dave, Huang, Tzu-Hsuan, Chaparro-Riggers, Javier
Published in Cancer immunology research (01.10.2021)
Published in Cancer immunology research (01.10.2021)
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Journal Article
GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T CellsSummary
Yannick S. Rakké, Lucia Campos Carrascosa, Adriaan A. van Beek, Valeska de Ruiter, Rachelle S. van Gemerden, Michail Doukas, Pascal G. Doornebosch, Maarten Vermaas, Susan ter Borg, Erwin van der Harst, Peter Paul L.O. Coene, Mike Kliffen, Dirk J. Grünhagen, Cornelis Verhoef, Jan N.M. IJzermans, Jaap Kwekkeboom, Dave Sprengers
Published in Cellular and molecular gastroenterology and hepatology (01.01.2023)
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Published in Cellular and molecular gastroenterology and hepatology (01.01.2023)
Journal Article
588 Targeting GITR enhances human tumour-infiltrating T cell functionality in mismatch repair proficient primary colorectal carcinoma and liver metastases
Rakké, Yannick, Lucia Campos Carrascosa, Adriaan van Beek, de Ruiter, Valeska, Doukas, Michael, Susan ter Borg, Doornebosch, Pascal, Vermaas, Maarten, van der Harst, Erwin, Coene, Peter Paul, Grünhagen, Dirk, Verhoef, Cornelis, IJzermans, Jan, Sprengers, Dave, Kwekkeboom, Jaap
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
TIGIT and PD1 Co-blockade Restores ex vivo Functions of Human Tumor-Infiltrating CD8+ T Cells in Hepatocellular CarcinomaSummary
Zhouhong Ge, Guoying Zhou, Lucia Campos Carrascosa, Erik Gausvik, Patrick P.C. Boor, Lisanne Noordam, Michael Doukas, Wojciech G. Polak, Türkan Terkivatan, Qiuwei Pan, R. Bart Takkenberg, Joanne Verheij, Joris I. Erdmann, Jan N.M. IJzermans, Maikel P. Peppelenbosch, Jaco Kraan, Jaap Kwekkeboom, Dave Sprengers
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
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Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
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