4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
Cai, Jiaqiang, Fradera, Xavier, van Zeeland, Mario, Dempster, Maureen, Cameron, Kenneth S., Bennett, D. Jonathan, Robinson, John, Popplestone, Lucy, Baugh, Mark, Westwood, Paul, Bruin, John, Hamilton, William, Kinghorn, Emma, Long, Clive, Uitdehaag, Joost C.M.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pkₐ
Arbuckle, Wullie, Baugh, Mark, Belshaw, Simone, Bennett, D. Jonathan, Bruin, John, Cai, Jiaqiang, Cameron, Kenneth S, Claxton, Chris, Dempster, Maureen, Everett, Kathryn, Fradera, Xavier, Hamilton, William, Jones, Philip S, Kinghorn, Emma, Long, Clive, Martin, Iain, Robinson, John, Westwood, Paul
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Get full text
Journal Article
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Cai, Jiaqiang, Baugh, Mark, Black, Darcey, Long, Clive, Jonathan Bennett, D., Dempster, Maureen, Fradera, Xavier, Gillespie, Jonathan, Andrews, Fiona, Boucharens, Sylviane, Bruin, John, Cameron, Kenneth S., Cumming, Iain, Hamilton, William, Jones, Philip S., Kaptein, Allard, Kinghorn, Emma, Maidment, Maurice, Martin, Iain, Mitchell, Ann, Rankovic, Zoran, Robinson, John, Scullion, Paul, Uitdehaag, Joost C.M., Vink, Paul, Westwood, Paul, van Zeeland, Mario, van Berkom, Leon, Bastiani, Martijn, Meulemans, Tommi
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Cai, Jiaqiang, Bennett, D. Jonathan, Rankovic, Zoran, Dempster, Maureen, Fradera, Xavier, Gillespie, Jonathan, Cumming, Iain, Finlay, William, Baugh, Mark, Boucharens, Sylviane, Bruin, John, Cameron, Kenneth S., Hamilton, William, Kerr, Jennifer, Kinghorn, Emma, McGarry, George, Robinson, John, Scullion, Paul, Uitdehaag, Joost C.M., van Zeeland, Mario, Potin, Dominique, Saniere, Laurent, Fouquet, Andre, Chevallier, Francois, Deronzier, Hortense, Dorleans, Cecile, Nicolai, Eric
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pk sub(a)
Arbuckle, Wullie, Baugh, Mark, Belshaw, Simone, Bennett, DJonathan, Bruin, John, Cai, Jiaqiang, Cameron, Kenneth S, Claxton, Chris, Dempster, Maureen, Everett, Kathryn, Fradera, Xavier, Hamilton, William, Jones, Philip S, Kinghorn, Emma, Long, Clive, Martin, Iain, Robinson, John, Westwood, Paul
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Get full text
Journal Article
1 H-Imidazo[4,5- c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen p k a
Arbuckle, Wullie, Baugh, Mark, Belshaw, Simone, Bennett, D. Jonathan, Bruin, John, Cai, Jiaqiang, Cameron, Kenneth S., Claxton, Chris, Dempster, Maureen, Everett, Kathryn, Fradera, Xavier, Hamilton, William, Jones, Philip S., Kinghorn, Emma, Long, Clive, Martin, Iain, Robinson, John, Westwood, Paul
Published in Bioorganic & medicinal chemistry letters (2011)
Published in Bioorganic & medicinal chemistry letters (2011)
Get full text
Journal Article
Optimization of Reaction Conditions for REM Resin-Bound Quaternization Reactions
Cameron, Kenneth S, Morphy, J. Richard, Rankovic, Zoran, York, Mark
Published in Journal of combinatorial chemistry (01.05.2002)
Published in Journal of combinatorial chemistry (01.05.2002)
Get full text
Journal Article
An NMR study of cyclodextrin complexes of the steroidal neuromuscular blocker drug Rocuronium Bromide
Cameron, Kenneth S., Fletcher, Dan, Fielding, Lee
Published in Magnetic resonance in chemistry (01.04.2002)
Published in Magnetic resonance in chemistry (01.04.2002)
Get full text
Journal Article