The Antitumor Activity of IMGN529, a CD37-Targeting Antibody-Drug Conjugate, Is Potentiated by Rituximab in Non-Hodgkin Lymphoma Models
Hicks, Stuart W., Lai, Katharine C., Gavrilescu, L. Cristina, Yi, Yong, Sikka, Surina, Shah, Prerak, Kelly, Meghan E., Lee, Jenny, Lanieri, Leanne, Ponte, Jose F., Sloss, Callum M., Romanelli, Angela
Published in Neoplasia (New York, N.Y.) (01.09.2017)
Published in Neoplasia (New York, N.Y.) (01.09.2017)
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The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models
Hicks, Stuart W, Tarantelli, Chiara, Wilhem, Alan, Gaudio, Eugenio, Li, Min, Arribas, Alberto J, Spriano, Filippo, Bordone, Roberta, Cascione, Luciano, Lai, Katharine C, Qiu, Qifeng, Taborelli, Monica, Rossi, Davide, Stussi, Georg, Zucca, Emanuele, Stathis, Anastasios, Sloss, Callum M, Bertoni, Francesco
Published in Haematologica (Roma) (01.08.2019)
Published in Haematologica (Roma) (01.08.2019)
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MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana
Al-Mutairi, Mashael S, Cadalbert, Laurence C, McGachy, H Adrienne, Shweash, Muhannad, Schroeder, Juliane, Kurnik, Magdalena, Sloss, Callum M, Bryant, Clare E, Alexander, James, Plevin, Robin
Published in PLoS pathogens (01.11.2010)
Published in PLoS pathogens (01.11.2010)
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Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells
Sloss, Callum M, Wang, Fang, Liu, Rong, Xia, Lijun, Houston, Michael, Ljungman, David, Palladino, Michael A, Cusack, Jr, James C
Published in Clinical cancer research (15.08.2008)
Published in Clinical cancer research (15.08.2008)
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Selective BRAFV600E Inhibition Enhances T-Cell Recognition of Melanoma without Affecting Lymphocyte Function
BONI, Andrea, COGDILL, Alexandria P, TSAO, Hensin, WARGO, Jennifer A, PING DANG, UDAYAKUMAR, Durga, NJAUW, Ching-Ni Jenny, SLOSS, Callum M, FERRONE, Cristina R, FLAHERTY, Keith T, LAWRENCE, Donald P, FISHER, David E
Published in Cancer research (Chicago, Ill.) (01.07.2010)
Published in Cancer research (Chicago, Ill.) (01.07.2010)
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Exposure-response relationships of mirvetuximab soravtansine in patients with folate receptor-α-positive ovarian cancer: Justification of therapeutic dose regimen
Tu, Ya-Ping, Lagraauw, H Maxime, Method, Michael, Wang, Yuemei, Hanze, Eva, Li, Lingling, Parrott, Timothy, Sloss, Callum M, Westin, Eric H
Published in British journal of clinical pharmacology (22.09.2024)
Published in British journal of clinical pharmacology (22.09.2024)
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Population pharmacokinetics of mirvetuximab soravtansine in patients with folate receptor‐α positive ovarian cancer: The antibody–drug conjugate, payload and metabolite
Tu, Ya‐Ping, Hanze, Eva, Zhu, Fengying, Lagraauw, H. Maxime, Sloss, Callum M., Method, Michael, Esteves, Brooke, Westin, Eric H., Berkenblit, Anna
Published in British journal of clinical pharmacology (01.02.2024)
Published in British journal of clinical pharmacology (01.02.2024)
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Development of an FRα Companion Diagnostic Immunohistochemical Assay for Mirvetuximab Soravtansine
James, Racheal L, Sisserson, Taryn, Cai, Zhuangyu, Dumas, Megan E, Inge, Landon J, Ranger-Moore, James, Mason, Albert, Sloss, Callum M, McArthur, Katherine
Published in Archives of pathology & laboratory medicine (1976) (01.11.2024)
Published in Archives of pathology & laboratory medicine (1976) (01.11.2024)
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IMGN779, a Novel CD33-Targeting Antibody-Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML
Kovtun, Yelena, Noordhuis, Paul, Whiteman, Kathleen R, Watkins, Krystal, Jones, Gregory E, Harvey, Lauren, Lai, Katharine C, Portwood, Scott, Adams, Sharlene, Sloss, Callum M, Schuurhuis, Gerrit Jan, Ossenkoppele, Gert, Wang, Eunice S, Pinkas, Jan
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Pivekimab sunirine (IMGN632), a novel CD123-targeting antibody–drug conjugate, in relapsed or refractory acute myeloid leukaemia: a phase 1/2 study
Daver, Naval G, Montesinos, Pau, DeAngelo, Daniel J, Wang, Eunice S, Papadantonakis, Nikolaos, Todisco, Elisabetta, Sweet, Kendra L, Pemmaraju, Naveen, Lane, Andrew A, Torres-Miñana, Laura, Thompson, James E, Konopleva, Marina Y, Sloss, Callum M, Watkins, Krystal, Bedse, Gaurav, Du, Yining, Malcolm, Kara E, Zweidler-McKay, Patrick A, Kantarjian, Hagop M
Published in The lancet oncology (01.03.2024)
Published in The lancet oncology (01.03.2024)
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Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic
Kearns, Jeffrey D, Bukhalid, Raghida, Sevecka, Mark, Tan, Gege, Gerami-Moayed, Nastaran, Werner, Shannon L, Kohli, Neeraj, Burenkova, Olga, Sloss, Callum M, King, Anne M, Fitzgerald, Jonathan B, Nielsen, Ulrik B, Wolf, Beni B
Published in Molecular cancer therapeutics (01.07.2015)
Published in Molecular cancer therapeutics (01.07.2015)
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A Study of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate, for Patients with Frontline and Relapsed/Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Pemmaraju, Naveen, Marconi, Giovanni, Todisco, Elisabetta, Montesinos, Pau, Lane, Andrew A., Sweet, Kendra, Wang, Eunice S., Deconinck, Eric, Rizzieri, David A, Walter, Roland B., Aribi, Ahmed, Lebon, Delphine, Levy, Moshe Y., Mazzarella, Luca, Martinelli, Giovanni, Gigli, Federica, Erba, Harry P., Acuña-Cruz, Evelyn, Konopleva, Marina, Kantarjian, Hagop, Sloss, Callum M, Wang, Jiuzhou, Malcolm, Kara E, Zweidler-McKay, Patrick A, DeAngelo, Daniel J., Daver, Naval
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-lndependent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells
SLOSS, Callum M, FANG WANG, RONG LIU, LIJUN XIA, HOUSTON, Michael, LJUNGMAN, David, PALLADINO, Michael A, CUSACK, James C
Published in Clinical cancer research (15.08.2008)
Published in Clinical cancer research (15.08.2008)
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Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2
Cadalbert, Laurence C., Sloss, Callum M., Cunningham, Margaret R., Al-Mutairi, Mashael, McIntire, Alan, Shipley, Janet, Plevin, Robin
Published in Cellular signalling (01.03.2010)
Published in Cellular signalling (01.03.2010)
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Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase
Cadalbert, Laurence, Sloss, Callum M., Cameron, Pamela, Plevin, Robin
Published in Cellular signalling (01.10.2005)
Published in Cellular signalling (01.10.2005)
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Journal Article
Disruption of two putative nuclear localization sequences is required for cytosolic localization of mitogen-activated protein kinase phosphatase-2
Sloss, Callum M., Cadalbert, Laurence, Finn, Stephen G., Fuller, Stephen J., Plevin, Robin
Published in Cellular signalling (01.06.2005)
Published in Cellular signalling (01.06.2005)
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Combining IMGN632, a Novel CD123-Targeting Antibody Drug Conjugate with Azacitidine and Venetoclax Facilitates Apoptosis in Vitro and Prolongs Survival In Vivo in AML Models
Kuruvilla, Vinitha Mary, Zhang, Qi, Daver, Naval, Watkins, Krystal, Sloss, Callum M, Zweidler-McKay, Patrick A, Romanelli, Angela, Konopleva, Marina
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia
Lock, Richard B, Evans, Kathryn, Randall, Joanna, Erickson, Stephen W, Earley, Eric J, Neuhauser, Steven, Stearns, Tim, Philip, Vivek, Teicher, Beverly A, Watkins, Krystal, Sloss, Callum M, Zweidler-McKay, Patrick A, Smith, Malcolm A
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Abstract 1841: IMGC936, an investigational ADAM9-targeting antibody drug conjugate, is active against patient-derived ADAM9-expressing xenograft models
Ab, Olga, Scribner, Juniper A., Sinkevicius, Kerstin, Loo, Deryk, Hicks, Stuart W., Watkins, Krystal, Chen, Francine Z., Espelin, Christopher, Themeles, Marian, Li, Ying, Bohac, Chet, McKay, Patrick Zweidler, Moore, Paul A., Sloss, Callum M., Bonvini, Ezio, Westin, Eric H.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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IMGN632, a CD123-Alkylating ADC Bearing a DNA-Alkylating IGN Payload, Combines Effectively with Azacitidine and Venetoclax In Vivo, Prolonging Survival in Preclinical Models of Human Acute Myeloid Leukemia (AML)
Kuruvilla, Vinitha Mary, McCarthy, Rebecca, Zhang, Qi, Sloss, Callum M., Zweidler-McKay, Patrick A., Romanelli, Angela, Adams, Sharlene, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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