Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Published in The EMBO journal (15.09.2020)
Published in The EMBO journal (15.09.2020)
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Inhibitors of SARS-CoV-2 PLpro
Calleja, Dale J, Lessene, Guillaume, Komander, David
Published in Frontiers in chemistry (26.04.2022)
Published in Frontiers in chemistry (26.04.2022)
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Journal Article
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Balka, Katherine R., Louis, Cynthia, Saunders, Tahnee L., Smith, Amber M., Calleja, Dale J., D’Silva, Damian B., Moghaddas, Fiona, Tailler, Maximilien, Lawlor, Kate E., Zhan, Yifan, Burns, Christopher J., Wicks, Ian P., Miner, Jonathan J., Kile, Benjamin T., Masters, Seth L., De Nardo, Dominic
Published in Cell reports (Cambridge) (07.04.2020)
Published in Cell reports (Cambridge) (07.04.2020)
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Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape
Wu, Xinyu, Go, Margareta, Nguyen, Julie V., Kuchel, Nathan W., Lu, Bernadine G. C., Zeglinski, Kathleen, Lowes, Kym N., Calleja, Dale J., Mitchell, Jeffrey P., Lessene, Guillaume, Komander, David, Call, Matthew E., Call, Melissa J.
Published in Nature communications (23.07.2024)
Published in Nature communications (23.07.2024)
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Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Published in Nature communications (02.12.2021)
Published in Nature communications (02.12.2021)
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Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Published in Nature communications (01.12.2023)
Published in Nature communications (01.12.2023)
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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
Calleja, Dale J, Kuchel, Nathan, Lu, Bernadine G C, Birkinshaw, Richard W, Klemm, Theresa, Doerflinger, Marcel, Cooney, James P, Mackiewicz, Liana, Au, Amanda E, Yap, Yu Q, Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E, Call, Melissa J, Lechtenberg, Bernhard C, Czabotar, Peter E, Pellegrini, Marc, Charman, Susan A, Lowes, Kym N, Mitchell, Jeffrey P, Nachbur, Ueli, Lessene, Guillaume, Komander, David
Published in Frontiers in chemistry (12.04.2022)
Published in Frontiers in chemistry (12.04.2022)
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Journal Article
Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
Yabal, Monica, Calleja, Dale J., Simpson, Daniel S., Lawlor, Kate E.
Published in Journal of leukocyte biology (01.02.2019)
Published in Journal of leukocyte biology (01.02.2019)
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Journal Article
Understanding SOCS protein specificity
Linossi, Edmond M., Calleja, Dale J., Nicholson, Sandra E.
Published in Growth factors (Chur, Switzerland) (04.07.2018)
Published in Growth factors (Chur, Switzerland) (04.07.2018)
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Journal Article
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
Yu, Chien-Hsiung, Davidson, Sophia, Harapas, Cassandra R., Hilton, James B., Mlodzianoski, Michael J., Laohamonthonkul, Pawat, Louis, Cynthia, Low, Ronnie Ren Jie, Moecking, Jonas, De Nardo, Dominic, Balka, Katherine R., Calleja, Dale J., Moghaddas, Fiona, Ni, Erya, McLean, Catriona A., Samson, Andre L., Tyebji, Shiraz, Tonkin, Christopher J., Bye, Christopher R., Turner, Bradley J., Pepin, Genevieve, Gantier, Michael P., Rogers, Kelly L., McArthur, Kate, Crouch, Peter J., Masters, Seth L.
Published in Cell (29.10.2020)
Published in Cell (29.10.2020)
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NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity
Moecking, Jonas, Laohamonthonkul, Pawat, Chalker, Katelyn, White, Marquitta J., Harapas, Cassandra R., Yu, Chien-Hsiung, Davidson, Sophia, Hrovat-Schaale, Katja, Hu, Donglei, Eng, Celeste, Huntsman, Scott, Calleja, Dale J., Horvat, Jay C., Hansbro, Phil M., O’Donoghue, Robert J.J., Ting, Jenny P., Burchard, Esteban G., Geyer, Matthias, Gerlic, Motti, Masters, Seth L.
Published in Journal of allergy and clinical immunology (01.06.2021)
Published in Journal of allergy and clinical immunology (01.06.2021)
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Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
Wilde, Mary-Louise, Ruparel, Ushma, Klemm, Theresa, Lee, V Vern, Calleja, Dale J, Komander, David, Tonkin, Christopher J
Published in Life science alliance (01.06.2023)
Published in Life science alliance (01.06.2023)
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Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24
Davidson, Sophia, Yu, Chien-Hsiung, Steiner, Annemarie, Ebstein, Frédéric, Baker, Paul J, Jarur-Chamy, Valentina, Hrovat Schaale, Katja, Laohamonthonkul, Pawat, Kong, Klara, Calleja, Dale J, Harapas, Cassandra R, Balka, Katherine R, Mitchell, Jacob, Jackson, Jacob T, Geoghegan, Niall D, Moghaddas, Fiona, Rogers, Kelly L, Mayer-Barber, Katrin D, De Jesus, Adriana A, De Nardo, Dominic, Kile, Benjamin T, Sadler, Anthony J, Poli, M Cecilia, Krüger, Elke, Goldbach Mansky, Raphaela, Masters, Seth L
Published in Science immunology (11.02.2022)
Published in Science immunology (11.02.2022)
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Journal Article
Mechanism and inhibition of SARS-CoV-2 PLpro
Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine G C, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Zhong Yan Gan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi-Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Published in bioRxiv (19.06.2020)
Published in bioRxiv (19.06.2020)
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