Mini‐Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study
Spracklin, Douglas K., Chen, Danny, Bergman, Arthur J., Callegari, Ernesto, Obach, R. Scott
Published in CPT: pharmacometrics and systems pharmacology (01.08.2020)
Published in CPT: pharmacometrics and systems pharmacology (01.08.2020)
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Journal Article
A comprehensive non‐clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder
Callegari, Ernesto, Malhotra, Bimal, Bungay, Peter J., Webster, Rob, Fenner, Katherine S., Kempshall, Sarah, LaPerle, Jennifer L., Michel, Martin C., Kay, Gary G.
Published in British journal of clinical pharmacology (01.08.2011)
Published in British journal of clinical pharmacology (01.08.2011)
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Journal Article
Physiologically‐Based Pharmacokinetic Modeling of the Drug–Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid
Callegari, Ernesto, Lin, Jian, Tse, Susanna, Goosen, Theunis C., Sahasrabudhe, Vaishali
Published in CPT: pharmacometrics and systems pharmacology (01.02.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.02.2021)
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Journal Article
Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model
Chen, Yuan, Cabalu, Tamara D., Callegari, Ernesto, Einolf, Heidi, Liu, Lichuan, Parrott, Neil, Peters, Sheila Annie, Schuck, Edgar, Sharma, Pradeep, Tracey, Helen, Upreti, Vijay V., Zheng, Ming, Zhu, Andy Z.X., Hall, Stephen D.
Published in CPT: pharmacometrics and systems pharmacology (01.09.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.09.2019)
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Journal Article
In vitro characterization of ertugliflozin glucuronidation
Lapham, Kimberly, Callegari, Ernesto, Lin, Jian, Niosi, Mark, Orozco, Christine, Sharma, Raman, Goosen, Theunis
Published in Drug metabolism and pharmacokinetics (01.01.2019)
Published in Drug metabolism and pharmacokinetics (01.01.2019)
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Journal Article
THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL
Doran, Angela, Obach, R Scott, Smith, Bill J, Hosea, Natilie A, Becker, Stacey, Callegari, Ernesto, Chen, Cuiping, Chen, Xi, Choo, Edna, Cianfrogna, Julie, Cox, Loretta M, Gibbs, John P, Gibbs, Megan A, Hatch, Heather, Hop, Cornelis E C A, Kasman, Ilana N, Laperle, Jennifer, Liu, Jianhua, Liu, Xingrong, Logman, Michael, Maclin, Debra, Nedza, Frank M, Nelson, Frederick, Olson, Emily, Rahematpura, Sandhya, Raunig, David, Rogers, Sabrinia, Schmidt, Kari, Spracklin, Douglas K, Szewc, Mark, Troutman, Matthew, Tseng, Elaine, Tu, Meihua, Van Deusen, Jeffrey W, Venkatakrishnan, Karthik, Walens, Gary, Wang, Ellen Q, Wong, Diane, Yasgar, Adam S, Zhang, Chenghong
Published in Drug metabolism and disposition (01.01.2005)
Published in Drug metabolism and disposition (01.01.2005)
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Journal Article
A comprehensive listing of bioactivation pathways of organic functional groups
Kalgutkar, Amit S, Gardner, Iain, Obach, R Scott, Shaffer, Christopher L, Callegari, Ernesto, Henne, Kirk R, Mutlib, Abdul E, Dalvie, Deepak K, Lee, Jae S, Nakai, Yasuhiro, O'Donnell, John P, Boer, Jason, Harriman, Shawn P
Published in Current drug metabolism (01.06.2005)
Published in Current drug metabolism (01.06.2005)
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Journal Article
End‐to‐end application of model‐informed drug development for ertugliflozin, a novel sodium‐glucose cotransporter 2 inhibitor
Fediuk, Daryl J., Nucci, Gianluca, Dawra, Vikas K., Callegari, Ernesto, Zhou, Susan, Musante, Cynthia J., Liang, Yali, Sweeney, Kevin, Sahasrabudhe, Vaishali
Published in CPT: pharmacometrics and systems pharmacology (01.06.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2021)
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Journal Article
Physiologically based pharmacokinetic modeling of the drug drug interaction between rifampin and SGLT2 inhibitors: The contribution of CYP induction to the observed interaction
Callegari, Ernesto, Lin, Jian, Tse, Susanna, Goosen, Theunis C., Sahasrabudhe, Vaishali, Kumar, Vikas
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Journal Article
Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration
XINGRONG LIU, SMITH, Bill J, HOSEA, Natilie, JIANHUA LIU, NELSON, Frederick R, SZEWC, Mark A, VAN DEUSEN, Jeffrey, CUIPING CHEN, CALLEGARI, Ernesto, BECKER, Stacey L, XI CHEN, CIANFROGNA, Julie, DORAN, Angela C, DORAN, Shawn D, GIBBS, John P
Published in Drug metabolism and disposition (01.09.2006)
Published in Drug metabolism and disposition (01.09.2006)
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Journal Article
Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding
Liu, Xingrong, Smith, Bill J, Chen, Cuiping, Callegari, Ernesto, Becker, Stacey L, Chen, Xi, Cianfrogna, Julie, Doran, Angela C, Doran, Shawn D, Gibbs, John P, Hosea, Natilie, Liu, Jianhua, Nelson, Frederick R, Szewc, Mark A, Van Deusen, Jeffery
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
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Journal Article
Physiologically Based Pharmacokinetic Modeling of the Drug-Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical Study
Callegari, Ernesto, Tse, Susanna, Doran, Angela C, Goosen, Theunis C, Shaik, Naveed
Published in Journal of clinical pharmacology (01.01.2024)
Published in Journal of clinical pharmacology (01.01.2024)
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Journal Article
Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects
Miao, Zhuang, Nucci, Gianluca, Amin, Neeta, Sharma, Raman, Mascitti, Vincent, Tugnait, Meera, Vaz, Alfin D, Callegari, Ernesto, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.02.2013)
Published in Drug metabolism and disposition (01.02.2013)
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Journal Article
In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
Lapham, Kimberly, Callegari, Ernesto, Cianfrogna, Julie, Lin, Jian, Niosi, Mark, Orozco, Christine C, Sharma, Raman, Goosen, Theunis C
Published in Drug metabolism and disposition (01.12.2020)
Published in Drug metabolism and disposition (01.12.2020)
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Journal Article
Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model
Ji, Changhua, Guha, Mausumee, Zhu, Xu, Whritenour, Jessica, Hemkens, Michelle, Tse, Susanna, Walker, Gregory S, Evans, Ellen, Khan, Nasir K, Finkelstein, Martin B, Callegari, Ernesto, Obach, R. Scott
Published in Chemical research in toxicology (21.01.2020)
Published in Chemical research in toxicology (21.01.2020)
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Journal Article
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S‑Warfarin: In Vitro Studies and Mechanistic Evaluation
Bi, Yi-an, Lin, Jian, Mathialagan, Sumathy, Tylaska, Laurie, Callegari, Ernesto, Rodrigues, A. David, Varma, Manthena V. S
Published in Molecular pharmaceutics (05.03.2018)
Published in Molecular pharmaceutics (05.03.2018)
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Journal Article
Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data
Nguyen, Hoa Q, Kimoto, Emi, Callegari, Ernesto, Obach, R Scott
Published in Drug metabolism and disposition (01.05.2016)
Published in Drug metabolism and disposition (01.05.2016)
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Journal Article
Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models
Nguyen, Hoa Q., Lin, Jian, Kimoto, Emi, Callegari, Ernesto, Tse, Susanna, Obach, R. Scott
Published in Journal of pharmaceutical sciences (01.09.2017)
Published in Journal of pharmaceutical sciences (01.09.2017)
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Journal Article
The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine
Nguyen, Hoa Q, Callegari, Ernesto, Obach, R Scott
Published in Drug metabolism and disposition (01.10.2016)
Published in Drug metabolism and disposition (01.10.2016)
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Journal Article