Identification of host antioxidant effectors as thioridazine targets: Impact on cardiomyocytes infection and Trypanosoma cruzi-induced acute myocarditis
Liz Belli Cassa Domingues, Elisa, Gonçalves-Santos, Elda, Santana Caldas, Ivo, Vilela Gonçalves, Reggiani, Caetano-da-Silva, José Edson, Cardoso Santos, Eliziária, Mól Pelinsari, Silvania, Figueiredo Diniz, Lívia, Dias Novaes, Rômulo
Published in Biochimica et biophysica acta. Molecular basis of disease (01.08.2024)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.08.2024)
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An evaluation of benznidazole as a Chagas disease therapeutic
Caldas, Ivo S, Santos, Elda G, Novaes, Rômulo D
Published in Expert opinion on pharmacotherapy (13.10.2019)
Published in Expert opinion on pharmacotherapy (13.10.2019)
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Fexinidazole: a potential new drug candidate for Chagas disease
Bahia, Maria Terezinha, de Andrade, Isabel Mayer, Martins, Tassiane Assíria Fontes, do Nascimento, Álvaro Fernando da Silva, Diniz, Lívia de Figueiredo, Caldas, Ivo Santana, Talvani, André, Trunz, Bernadette Bourdin, Torreele, Els, Ribeiro, Isabela
Published in PLoS neglected tropical diseases (01.11.2012)
Published in PLoS neglected tropical diseases (01.11.2012)
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Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments
Diniz, Lívia de Figueiredo, Urbina, Julio A, de Andrade, Isabel Mayer, Mazzeti, Ana Lia, Martins, Tassiane Assíria F, Caldas, Ivo Santana, Talvani, André, Ribeiro, Isabela, Bahia, Maria Terezinha
Published in PLoS neglected tropical diseases (01.08.2013)
Published in PLoS neglected tropical diseases (01.08.2013)
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Matrix metalloproteinases inhibition reveals the association between inflammation, collagen accumulation and intestinal translocation of Schistosoma mansoni eggs in vivo
Silva, Thiago D, Gonçalves-Santos, Elda, Gonçalves, Reggiani V, Souza, Raquel L M, Caetano, José Edson, Caldas, Ivo S, Diniz, Livia F, Marques, Marcos J, Novaes, Rômulo D
Published in International immunopharmacology (25.01.2024)
Published in International immunopharmacology (25.01.2024)
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Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice
Felizardo, Amanda A., Caldas, Ivo S., Mendonça, Andréa A.S., Gonçalves, Reggiani V., Tana, Fernanda L., Almeida, Leonardo A., Novaes, Rômulo D.
Published in Free radical biology & medicine (01.12.2018)
Published in Free radical biology & medicine (01.12.2018)
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Journal Article
Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy
Gonçalves-Santos, Elda, Vilas-Boas, Diego F., Diniz, Lívia F., Veloso, Marcia P., Mazzeti, Ana L., Rodrigues, Maria R., Oliveira, Carla M., Fernandes, Victor Hugo C., Novaes, Rômulo D., Chagas-Paula, Daniela A., Caldas, Ivo S.
Published in International immunopharmacology (01.12.2019)
Published in International immunopharmacology (01.12.2019)
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Applicability of plant-based products in the treatment of Trypanosoma cruzi and Trypanosoma brucei infections: a systematic review of preclinical in vivo evidence
PEREIRA, RODRIGO M., GRECO, GLÍCIA M. Z., MOREIRA, ANDREIA M., CHAGAS, PABLO F., CALDAS, IVO S., GONÇALVES, REGGIANI V., NOVAES, RÔMULO D.
Published in Parasitology (01.09.2017)
Published in Parasitology (01.09.2017)
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Pharmacological potential of new metronidazole/eugenol/dihydroeugenol hybrids against Trypanosoma cruzi in vitro and in vivo
Gonçalves-Santos, Elda, Caldas, Ivo S., Fernandes, Valquiria Â., Franco, Lucas L., Pelozo, Mônica F., Feltrim, Fernando, Maciel, Juliana S., Machado, Jose Vaz C., Gonçalves, Reggiani V., Novaes, Rômulo D.
Published in International immunopharmacology (01.08.2023)
Published in International immunopharmacology (01.08.2023)
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Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study
Souza-Silva, Thaiany G., Vilas-Boas, Diego F., Gonçalves-Santos, Elda, Mazzeti, Ana Lia, Caldas, Ivo S., Gonçalves, Reggiani V., Diniz, Lívia F., Novaes, Rômulo D.
Published in Life sciences (1973) (15.09.2020)
Published in Life sciences (1973) (15.09.2020)
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Antitrypanosomal Activity of Fexinidazole Metabolites, Potential New Drug Candidates for Chagas Disease
BAHIA, Maria T, NASCIMENTO, Alvaro F. S, KOLTUN, Maria, SAUNDERS, Jessica, WHITE, Karen L, SCANDALE, Ivan, CHARMAN, Susan A, CHATELAIN, Eric, MAZZETI, Ana Lia, MARQUES, Luiz F, GONCALVES, Karolina R, MOTA, Ludmilla W. R, DINIZ, Lívia de F, CALDAS, Ivo S, TALVANI, André, SHACKLEFORD, David M
Published in Antimicrobial agents and chemotherapy (01.08.2014)
Published in Antimicrobial agents and chemotherapy (01.08.2014)
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The mitochondrial uncoupler 2,4-dinitrophenol modulates inflammatory and oxidative responses in Trypanosoma cruzi-induced acute myocarditis in mice
Caetano-da-Silva, José Edson, Gonçalves-Santos, Elda, Domingues, Elisa L.B.C., Caldas, Ivo S., Lima, Graziela D.A., Diniz, Lívia F., Gonçalves, Reggiani V., Novaes, Rômulo D.
Published in Cardiovascular pathology (01.09.2024)
Published in Cardiovascular pathology (01.09.2024)
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Schistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy
Lozano, Kelly J.G., Gonçalves Santos, Elda, Vilas Boas, Diego F., Oliveira, Raphaela R.G., Diniz, Lívia F., Benedetti, Monique D., Carneiro, Cláudia M., C. Bandeira, Lorena, Faria, Gilson, Gonçalves, Reggiani V., Novaes, Rômulo D., Caldas, Sérgio, Caldas, Ivo S.
Published in International immunopharmacology (15.02.2024)
Published in International immunopharmacology (15.02.2024)
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Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?
Mendonça, Andréa A.S., Gonçalves-Santos, Elda, Souza-Silva, Thaiany G., González-Lozano, Kelly J., Caldas, Ivo S., Gonçalves, Reggiani V., Diniz, Lívia F., Novaes, Rômulo D.
Published in Pharmacological research (01.08.2020)
Published in Pharmacological research (01.08.2020)
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4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection
Vilas-Boas, Diego F., Oliveira, Raphaela R.G., Gonçalves-Santos, Elda, Silva, Luana S., Diniz, Lívia F., Mazzeti, Ana L., Brancaglion, Guilherme A., Carvalho, Diogo T., Caldas, Sergio, Novaes, Rômulo D., Caldas, Ivo S.
Published in Acta tropica (01.04.2022)
Published in Acta tropica (01.04.2022)
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Effects of Ravuconazole Treatment on Parasite Load and Immune Response in Dogs Experimentally Infected with Trypanosoma cruzi
DE FIGUEIREDO DINIZ, Lívia, SANTANA CALDAS, Ivo, DA MATTA GUEDES, Paulo Marcos, CREPALDE, Geovam, DE LANA, Marta, MARTINS CARNEIRO, Cláudia, TALVANI, André, URBINA, Julio Alberto, TEREZINHA BAHIA, Maria
Published in Antimicrobial Agents and Chemotherapy (01.07.2010)
Published in Antimicrobial Agents and Chemotherapy (01.07.2010)
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Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice
Mendonça, Andréa A.S., Gonçalves-Santos, Elda, Souza-Silva, Thaiany G., González-Lozano, Kelly J., Caldas, Ivo S., Gonçalves, Reggiani V., Diniz, Lívia F., Novaes, Rômulo D.
Published in International immunopharmacology (01.08.2020)
Published in International immunopharmacology (01.08.2020)
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Journal Article
Real-time PCR strategy for parasite quantification in blood and tissue samples of experimental Trypanosoma cruzi infection
Caldas, Sérgio, Caldas, Ivo Santana, Diniz, Lívia de Figueiredo, Lima, Wanderson Geraldo de, Oliveira, Riva de Paula, Cecílio, Alzira Batista, Ribeiro, Isabela, Talvani, André, Bahia, Maria Terezinha
Published in Acta tropica (01.09.2012)
Published in Acta tropica (01.09.2012)
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Anti-urolithiatic and anti-inflammatory activities through a different mechanism of actions of Cissus gongylodes corroborated its ethnopharmacological historic
Salem, Paula P.O., Vieira, Nátalie B., Garcia, Daniela A., Nicácio, Karen J., Dias, Danielle F., de Paula, Ana C.C., Assis, Diego M., Caldas, Ivo S., Novaes, Romulo D., Marinho, Maria V., Rosa, Iara M.L., Soares, Marisi G., Chagas-Paula, Daniela A.
Published in Journal of ethnopharmacology (10.05.2020)
Published in Journal of ethnopharmacology (10.05.2020)
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Journal Article
Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions
Caldas, Ivo Santana, Talvani, André, Caldas, Sérgio, Carneiro, Cláudia Martins, de Lana, Marta, da Matta Guedes, Paulo Marcos, Bahia, Maria Terezinha
Published in Parasitology research (1987) (01.07.2008)
Published in Parasitology research (1987) (01.07.2008)
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