Identification of KasA as the cellular target of an anti-tubercular scaffold
Abrahams, Katherine A, Chung, Chun-Wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S, Cox, Jonathan A G, Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J, Moynihan, Patrick J, Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C, Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S, Bates, Robert H
Published in Nature communications (01.09.2016)
Published in Nature communications (01.09.2016)
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Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis
Guardia, Ana, Baiget, Jessica, Cacho, Mónica, Pérez, Arancha, Ortega-Guerra, Montserrat, Nxumalo, Winston, Khanye, Setshaba D, Rullas, Joaquín, Ortega, Fátima, Jiménez, Elena, Pérez-Herrán, Esther, Fraile-Gabaldón, María Teresa, Esquivias, Jorge, Fernández, Raquel, Porras-De Francisco, Esther, Encinas, Lourdes, Alonso, Marta, Giordano, Ilaria, Rivero, Cristina, Miguel-Siles, Juan, Osende, Javier G, Badiola, Katrina A, Rutledge, Peter J, Todd, Matthew H, Remuiñán, Modesto, Alemparte, Carlos
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
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Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
Remuiñán, Modesto J, Pérez-Herrán, Esther, Rullás, Joaquín, Alemparte, Carlos, Martínez-Hoyos, María, Dow, David J, Afari, Johnson, Mehta, Nalini, Esquivias, Jorge, Jiménez, Elena, Ortega-Muro, Fátima, Fraile-Gabaldón, María Teresa, Spivey, Vickey L, Loman, Nicholas J, Pallen, Mark J, Constantinidou, Chrystala, Minick, Douglas J, Cacho, Mónica, Rebollo-López, María José, González, Carolina, Sousa, Verónica, Angulo-Barturen, Iñigo, Mendoza-Losana, Alfonso, Barros, David, Besra, Gurdyal S, Ballell, Lluís, Cammack, Nicholas
Published in PloS one (17.04.2013)
Published in PloS one (17.04.2013)
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Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection
Negatu, Dereje A, González Del Río, Rubén, Cacho-Izquierdo, Mónica, Barros-Aguirre, David, Lelievre, Joël, Rullas, Joaquín, Casado, Patricia, Ganapathy, Uday S, Zimmerman, Matthew D, Gengenbacher, Martin, Dartois, Véronique, Dick, Thomas
Published in Antimicrobial agents and chemotherapy (16.02.2023)
Published in Antimicrobial agents and chemotherapy (16.02.2023)
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A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity
Ganapathy, Uday S, González del Rio, Rubén, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Published in Antimicrobial agents and chemotherapy (19.04.2021)
Published in Antimicrobial agents and chemotherapy (19.04.2021)
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A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus
Ganapathy, Uday S, Del Río, Rubén González, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D, Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Published in Antimicrobial agents and chemotherapy (17.11.2021)
Published in Antimicrobial agents and chemotherapy (17.11.2021)
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Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides
Brana, MF, Cacho, M, Ramos, A, Dominguez, MT, Pozuelo, JM, Abradelo, C, Rey-Stolle, MF, Yuste, M, Carrasco, C, Bailly, C
Published in Organic & biomolecular chemistry (21.02.2003)
Published in Organic & biomolecular chemistry (21.02.2003)
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Synthesis, Antitumor Activity, Molecular Modeling, and DNA Binding Properties of a New Series of Imidazonaphthalimides
Braña, Miguel F, Cacho, Mónica, García, Mario A, de Pascual-Teresa, Beatriz, Ramos, Ana, Acero, Nuria, Llinares, Francisco, Muñoz-Mingarro, Dolores, Abradelo, Cristina, Rey-Stolle, María Fernanda, Yuste, Mercedes
Published in Journal of medicinal chemistry (19.12.2002)
Published in Journal of medicinal chemistry (19.12.2002)
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Synthesis, Biological Evaluation, and Three-Dimensional Quantitative Structure−Activity Relationship Study of Small-Molecule Positive Modulators of Adrenomedullin
García, Mario A, Martín-Santamaría, Sonsoles, Cacho, Mónica, Moreno de la Llave, Fernando, Julián, Miguel, Martínez, Alfredo, de Pascual-Teresa, Beatriz, Ramos, Ana
Published in Journal of medicinal chemistry (16.06.2005)
Published in Journal of medicinal chemistry (16.06.2005)
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Mycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs
Blanco, Delia, Perez-Herran, Esther, Cacho, Mónica, Ballell, Lluís, Castro, Julia, González Del Río, Rubén, Lavandera, José Luis, Remuiñán, Modesto J, Richards, Cindy, Rullas, Joaquin, Vázquez-Muñiz, María Jesús, Woldu, Ermias, Zapatero-González, María Cleofé, Angulo-Barturen, Iñigo, Mendoza, Alfonso, Barros, David
Published in Antimicrobial agents and chemotherapy (01.04.2015)
Published in Antimicrobial agents and chemotherapy (01.04.2015)
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Exploring the SAR of the β‑Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite
Cunningham, Fraser, Esquivias, Jorge, Fernández-Menéndez, Raquel, Pérez, Arancha, Guardia, Ana, Escribano, Jaime, Rivero, Cristina, Vimal, Mythily, Cacho, Mónica, de Dios-Antón, Paco, Martínez-Martínez, María Santos, Jiménez, Elena, Huertas Valentín, Leticia, Rebollo-López, María José, López-Román, Eva María, Sousa-Morcuende, Verónica, Rullas, Joaquín, Neu, Margaret, Chung, Chun-wa, Bates, Robert H
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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Journal Article
High-throughput screen with the -transpeptidase Ldt of reveals novel classes of covalently reacting inhibitors
de Munnik, Mariska, Lang, Pauline A, De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H, Brem, Jürgen, Rodríguez Miquel, Beatriz, Schofield, Christopher J
Published in Chemical science (Cambridge) (05.07.2023)
Published in Chemical science (Cambridge) (05.07.2023)
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Journal Article
High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors
de Munnik, Mariska, Lang, Pauline A, De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H, Brem, Jürgen, Beatriz Rodríguez Miquel, Schofield, Christopher J
Published in Chemical science (Cambridge) (30.05.2023)
Published in Chemical science (Cambridge) (30.05.2023)
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Journal Article
High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors
de Munnik, Mariska, Lang, Pauline A, De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H, Brem, Jürgen, Rodríguez Miquel, Beatriz, Schofield, Christopher J
Published in Chemical science (Cambridge) (05.07.2023)
Published in Chemical science (Cambridge) (05.07.2023)
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Journal Article
New Analogues of Amonafide and Elinafide, Containing Aromatic Heterocycles: Synthesis, Antitumor Activity, Molecular Modeling, and DNA Binding Properties
Braña, Miguel F, Cacho, Mónica, García, Mario A, de Pascual-Teresa, Beatriz, Ramos, Ana, Domínguez, M. Teresa, Pozuelo, José M, Abradelo, Cristina, Rey-Stolle, María Fernanda, Yuste, Mercedes, Báñez-Coronel, Mónica, Lacal, Juan Carlos
Published in Journal of medicinal chemistry (11.03.2004)
Published in Journal of medicinal chemistry (11.03.2004)
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Journal Article
Chromophore-Modified Bisnaphthalimides: DNA Recognition, Topoisomerase Inhibition, and Cytotoxic Properties of Two Mono- and Bisfuronaphthalimides
Bailly, Christian, Carrasco, Carolina, Joubert, Alexandra, Bal, Christine, Wattez, Nicole, Hildebrand, Marie-Paule, Lansiaux, Amélie, Colson, Pierre, Houssier, Claude, Cacho, Monica, Ramos, Ana, Braña, Miguel F
Published in Biochemistry (Easton) (15.04.2003)
Published in Biochemistry (Easton) (15.04.2003)
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Journal Article
Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities
Julián, Miguel, Cacho, Mónica, García, Mario A., Martín-Santamaría, Sonsoles, de Pascual-Teresa, Beatriz, Ramos, Ana, Martínez, Alfredo, Cuttitta, Frank
Published in European journal of medicinal chemistry (01.08.2005)
Published in European journal of medicinal chemistry (01.08.2005)
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Journal Article
Pyrazolo[3,4-c]pyridazines as Novel and Selective Inhibitors of Cyclin-Dependent Kinases
Braña, Miguel F, Cacho, Mónica, García, M. Luisa, Mayoral, Elena P, López, Berta, de Pascual-Teresa, Beatriz, Ramos, Ana, Acero, Nuria, Llinares, Francisco, Muñoz-Mingarro, Dolores, Lozach, Olivier, Meijer, Laurent
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Journal Article
A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity
Ganapathy, Uday S, Del Rio, Rubén González, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Published in Antimicrobial agents and chemotherapy (01.05.2023)
Published in Antimicrobial agents and chemotherapy (01.05.2023)
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