Plasmodial Kinase Inhibitors: License to Cure?
Cabrera, Diego González, Horatscheck, André, Wilson, Colin R, Basarab, Greg, Eyermann, Charles J, Chibale, Kelly
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential
Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Journal Article
Novel Orally Active Antimalarial Thiazoles
González Cabrera, Diego, Douelle, Frederic, Feng, Tzu-Shean, Nchinda, Aloysius T, Younis, Yassir, White, Karen L, Wu, Quoc, Ryan, Eileen, Burrows, Jeremy N, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Chibale, Kelly
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Journal Article
Structure–Activity-Relationship Studies around the 2‑Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral in Vivo Activity
Younis, Yassir, Douelle, Frederic, González Cabrera, Diego, Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Street, Leslie J, White, Karen L, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Chibale, Kelly
Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
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Journal Article
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials
van der Watt, Mariëtte E, Reader, Janette, Churchyard, Alisje, Nondaba, Sindisiwe H, Lauterbach, Sonja B, Niemand, Jandeli, Abayomi, Sijuade, van Biljon, Riëtte A, Connacher, Jessica I, van Wyk, Roelof D J, Le Manach, Claire, Paquet, Tanya, González Cabrera, Diego, Brunschwig, Christel, Theron, Anjo, Lozano-Arias, Sonia, Rodrigues, Janneth F I, Herreros, Esperanza, Leroy, Didier, Duffy, James, Street, Leslie J, Chibale, Kelly, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie
Published in Journal of antimicrobial chemotherapy (01.05.2018)
Published in Journal of antimicrobial chemotherapy (01.05.2018)
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Journal Article
Phenolic Profile, Antioxidant and Enzyme Inhibition Properties of the Chilean Endemic Plant Ovidia pillopillo (Gay) Meissner (Thymelaeaceae)
Cortés, Carmen, González-Cabrera, Diego A, Barrientos, Ruth, Parra, Claudio, Romero-Parra, Javier, Pertino, Mariano Walter, Areche, Carlos, Sepúlveda, Beatriz, Bórquez, Jorge, Torres-Benítez, Alfredo, Simirgiotis, Mario J
Published in Metabolites (18.01.2022)
Published in Metabolites (18.01.2022)
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Facile Formation of Redox-Active Totally Organic Nanoparticles in Water by In Situ Reduction of Organic Precursors Stabilized through Aromatic-Aromatic Interactions by Aromatic Polyelectrolytes
Flores, Mario E., Garcés-Jerez, Pablo, Fernández, Daniel, Aros-Perez, Gustavo, González-Cabrera, Diego, Álvarez, Eduardo, Cañas, Ignacio, Oyarzun-Ampuero, Felipe, Moreno-Villoslada, Ignacio
Published in Macromolecular rapid communications. (01.11.2016)
Published in Macromolecular rapid communications. (01.11.2016)
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Journal Article
Structure–Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2‑Aminopyridines
González Cabrera, Diego, Douelle, Frederic, Younis, Yassir, Feng, Tzu-Shean, Le Manach, Claire, Nchinda, Aloysius T, Street, Leslie J, Scheurer, Christian, Kamber, Jolanda, White, Karen L, Montagnat, Oliver D, Ryan, Eileen, Katneni, Kasiram, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Charman, Susan A, Wittlin, Sergio, Chibale, Kelly
Published in Journal of medicinal chemistry (27.12.2012)
Published in Journal of medicinal chemistry (27.12.2012)
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Journal Article
Epitaxial growth in one dimension
Álvarez-Cuartas, Juan David, González-Cabrera, Diego Luis, Camargo, Manuel
Published in Journal of physics. Condensed matter (20.11.2024)
Published in Journal of physics. Condensed matter (20.11.2024)
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Journal Article
2,4-Diaminothienopyrimidines as Orally Active Antimalarial Agents
González Cabrera, Diego, Le Manach, Claire, Douelle, Frederic, Younis, Yassir, Feng, Tzu-Shean, Paquet, Tanya, Nchinda, Aloysius T, Street, Leslie J, Taylor, Dale, de Kock, Carmen, Wiesner, Lubbe, Duffy, Sandra, White, Karen L, Zabiulla, K. Mohammed, Sambandan, Yuvaraj, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Charman, Susan A, Avery, Vicky M, Wittlin, Sergio, Chibale, Kelly
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Journal Article
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria
Kandepedu, Nishanth, Gonzàlez Cabrera, Diego, Eedubilli, Srinivas, Taylor, Dale, Brunschwig, Christel, Gibhard, Liezl, Njoroge, Mathew, Lawrence, Nina, Paquet, Tanya, Eyermann, Charles J, Spangenberg, Thomas, Basarab, Gregory S, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Journal Article
Identification of a Potential Antimalarial Drug Candidate from a Series of 2‑Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle
Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Han, Ze, Bashyam, Sridevi, Zabiulla, Mohammed, Taylor, Dale, Lawrence, Nina, White, Karen L, Charman, Susan A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Botha, Mariëtte E, Nondaba, Sindisiswe H, Reader, Janette, Birkholtz, Lyn-Marie, Jiménez-Díaz, María Belén, Martínez, María Santos, Ferrer, Santiago, Angulo-Barturen, Iñigo, Meister, Stephan, Antonova-Koch, Yevgeniya, Winzeler, Elizabeth A, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Journal Article
Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 2
Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, Lawrence, Nina, Schwager, Sylva, Waterson, David, Witty, Michael J, Wittlin, Sergio, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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Journal Article
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum -Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines
Le Manach, Claire, Paquet, Tanya, Brunschwig, Christel, Njoroge, Mathew, Han, Ze, Gonzàlez Cabrera, Diego, Bashyam, Sridevi, Dhinakaran, Rajkumar, Taylor, Dale, Reader, Janette, Botha, Mariette, Churchyard, Alisje, Lauterbach, Sonja, Coetzer, Theresa L, Birkholtz, Lyn-Marie, Meister, Stephan, Winzeler, Elizabeth A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Jiménez-Díaz, María-Belén, Santos Martínez, María, Ferrer, Santiago, Angulo-Barturen, Iñigo, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Journal Article
Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1
Le Manach, Claire, Gonzàlez Cabrera, Diego, Douelle, Frederic, Nchinda, Aloysius T, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, White, Karen L, Ryan, Eileen, March, Corinne, Duffy, Sandra, Avery, Vicky M, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Structure–Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines
Gonzàlez Cabrera, Diego, Douelle, Frederic, Le Manach, Claire, Han, Ze, Paquet, Tanya, Taylor, Dale, Njoroge, Mathew, Lawrence, Nina, Wiesner, Lubbe, Waterson, David, Witty, Michael J, Wittlin, Sergio, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
A metal-complex-tolerant CuAAC 'click' protocol exemplified through the preparation of homo- and mixed-metal-coordinated [2]rotaxanes
Cabrera, Diego Gonzalez, Koivisto, Bryan D., Leigh, David A.
Published in Chemical communications (Cambridge, England) (01.01.2007)
Published in Chemical communications (Cambridge, England) (01.01.2007)
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