PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases
Cushing, Timothy D, Metz, Daniela P, Whittington, Douglas A, McGee, Lawrence R
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
Get full text
Journal Article
Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
Get full text
Journal Article
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors
Shin, Youngsook, Suchomel, Julia, Cardozo, Mario, Duquette, Jason, He, Xiao, Henne, Kirk, Hu, Yi-Ling, Kelly, Ron C, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wong, Simon, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
Get full text
Journal Article
Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure–activity relationship, and co-crystal structures
Li, Kexue, McGee, Lawrence R., Fisher, Ben, Sudom, Athena, Liu, Jinsong, Rubenstein, Steven M., Anwer, Mohmed K., Cushing, Timothy D., Shin, Youngsook, Ayres, Merrill, Lee, Fei, Eksterowicz, John, Faulder, Paul, Waszkowycz, Bohdan, Plotnikova, Olga, Farrelly, Ellyn, Xiao, Shou-Hua, Chen, Guoqing, Wang, Zhulun
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Get full text
Journal Article
Synthesis and SAR study of potent and selective PI3Kδ inhibitors
Bui, Minna, Hao, Xiaolin, Shin, Youngsook, Cardozo, Mario, He, Xiao, Henne, Kirk, Suchomel, Julia, McCarter, John, McGee, Lawrence R., San Miguel, Tisha, Medina, Julio C., Mohn, Deanna, Tran, Thuy, Wannberg, Sharon, Wong, Jamie, Wong, Simon, Zalameda, Leeanne, Metz, Daniela, Cushing, Timothy D.
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Get full text
Journal Article
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430)
Gonzalez-Lopez de Turiso, Felix, Hao, Xiaolin, Shin, Youngsook, Bui, Minna, Campuzano, Iain D. G, Cardozo, Mario, Dunn, Michelle C, Duquette, Jason, Fisher, Benjamin, Foti, Robert S, Henne, Kirk, He, Xiao, Hu, Yi-Ling, Kelly, Ron C, Johnson, Michael G, Lucas, Brian S, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
Get full text
Journal Article
Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors
Gonzalez-Lopez de Turiso, Felix, Shin, Youngsook, Brown, Matthew, Cardozo, Mario, Chen, Yi, Fong, David, Hao, Xiaolin, He, Xiao, Henne, Kirk, Hu, Yi-Ling, Johnson, Michael G, Kohn, Todd, Lohman, Julia, McBride, Helen J, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, Miner, Kent, Mohn, Deanna, Pattaropong, Vatee, Seganish, Jennifer, Simard, Jillian L, Wannberg, Sharon, Whittington, Douglas A, Yu, Gang, Cushing, Timothy D
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
Get full text
Journal Article
Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity
Taygerly, Joshua P., McGee, Lawrence R., Rubenstein, Steven M., Houze, Jonathan B., Cushing, Timothy D., Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R., Jaen, Juan, Miao, Shichang, Timmermans, Pieter B., Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao
Published in Bioorganic & medicinal chemistry (15.02.2013)
Published in Bioorganic & medicinal chemistry (15.02.2013)
Get full text
Journal Article
Stereocontrolled Total Synthesis of (+)-Paraherquamide B
Cushing, Timothy D, Sanz-Cervera, Juan F, Williams, Robert M
Published in Journal of the American Chemical Society (24.01.1996)
Published in Journal of the American Chemical Society (24.01.1996)
Get full text
Journal Article
Stereocontrolled total synthesis of (+)-paraherquamide B
Cushing, Timothy D, Sanz-Cervera, Juan F, Williams, Robert M
Published in Journal of the American Chemical Society (01.10.1993)
Published in Journal of the American Chemical Society (01.10.1993)
Get full text
Journal Article
A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit
Cushing, Timothy D., Baichwal, Vijay, Berry, Karen, Billedeau, Roland, Bordunov, Viola, Broka, Chris, Cardozo, Mario, Cheng, Peng, Clark, David, Dalrymple, Stacie, DeGraffenreid, Michael, Gill, Adrian, Hao, Xiaolin, Hawley, Ronald C., He, Xiao, Jaen, Juan C., Labadie, Sharada S., Labelle, Marc, Lehel, Csaba, Lu, Pu-Ping, McIntosh, Joel, Miao, Shichang, Parast, Camran, Shin, Youngsook, Sjogren, Eric B., Smith, Marie-Louise, Talamas, Francisco X., Tonn, George, Walker, Keith M., Walker, Nigel P.C., Wesche, Holger, Whitehead, Chris, Wright, Matt, Browner, Michelle F.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Get full text
Journal Article
A novel series of IKKβ inhibitors part II: Description of a potent and pharmacologically active series of analogs
Cushing, Timothy D., Baichwal, Vijay, Berry, Karen, Billedeau, Roland, Bordunov, Viola, Broka, Chris, Browner, Michelle F., Cardozo, Mario, Cheng, Peng, Clark, David, Dalrymple, Stacie, DeGraffenreid, Michael, Gill, Adrian, Hao, Xiaolin, Hawley, Ronald C., He, Xiao, Labadie, Sharada S., Labelle, Marc, Lehel, Csaba, Lu, Pu-Ping, McIntosh, Joel, Miao, Shichang, Parast, Camran, Shin, Youngsook, Sjogren, Eric B., Smith, Marie-Louise, Talamas, Francisco X., Tonn, George, Walker, Keith M., Walker, Nigel P.C., Wesche, Holger, Whitehead, Chris, Wright, Matt, Jaen, Juan C.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Get full text
Journal Article
HETEROCYCLIC COMPOUNDS AND THEIR USES
BUI MINNA HUE THANH, HAO XIAOLIN, CUSHING TIMOTHY D, LUCAS BRIAN, GONZALEZ LOPEZ DE TURISO FELIX
Year of Publication 05.12.2014
Get full text
Year of Publication 05.12.2014
Patent
HETEROCYCLIC COMPOUNDS AND THEIR USES
HE XIAO, LOHMAN JULIA WINSLOW, SHIN YOUNGSOOK, CUSHING TIMOTHY D, DUQUETTE JASON A
Year of Publication 23.09.2013
Get full text
Year of Publication 23.09.2013
Patent
HETEROCYCLIC COMPOUNDS AND THEIR USES
SIMARD JILLIAN L, KOHN TODD J, PATTAROPONG VATEE, CUSHING TIMOTHY D, DRANSFIELD PAUL JOHN, JOHNSON MICHAEL G, GONZALEZ LOPEZ DE TURISO FELIX
Year of Publication 06.02.2014
Get full text
Year of Publication 06.02.2014
Patent
PYRAZOLE AMIDE DERIVATIVE
HIRATA JUN, EPSTEIN OLEG, ZHENG XIAO MEI, KAKUDA SHINJI, NAKAJIMA RYOTA, BECK HILARY PLAKE, HUMAN JASON, CHAKKA NAGASREE, HIBIYA KENTA, PENNINGTON LEWIS D, WURZ RYAN P, SHIMADA KEIKO, FOX BRIAN M, HAO XIAOLIN, CEE VICTOR J, OONO HIROYUKI, SHIN YOUNGSOOK, HUA ZIHAO, SASAKI KOSUKE, WHITE RYAN D, BOOKER SHON KEITH, BREGMAN HOWARD, CUSHING TIMOTHY D, OKADA KAZUHISA, OLSON STEVEN H, YI SHUYAN, GEUNS MEYER STEPHANIE, LOPEZ PATRICIA
Year of Publication 09.12.2016
Get full text
Year of Publication 09.12.2016
Patent
POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES
CHEN YI, FISHER BENJAMIN, HE XIAO, BUI MINNA HUE THANH, HAO XIAOLIN, CUSHING TIMOTHY D, LUCAS BRIAN, JOHNSON MICHAEL G, DUQUETTE JASON A, GONZALEZ LOPEZ DE TURISO FELIX
Year of Publication 09.06.2014
Get full text
Year of Publication 09.06.2014
Patent
Template-Directed Interference Footprinting of Protein−Adenine Contacts
Min, Changhee, Cushing, Timothy D, Verdine, Gregory L
Published in Journal of the American Chemical Society (03.07.1996)
Published in Journal of the American Chemical Society (03.07.1996)
Get full text
Journal Article
A Practical Synthesis of a Potent and Selective Diacylglycerol Acyltransferase-1 (DGAT-1) Inhibitor
Shin, Youngsook, Bergeron, Philippe, Fox, Brian M., Kayser, Frank, McGee, Lawrence R., McKendry, Sharon, McMinn, Dustin L., Labelle, Marc, Cushing, Timothy D.
Published in Synthesis (Stuttgart) (01.07.2014)
Published in Synthesis (Stuttgart) (01.07.2014)
Get more information
Journal Article