Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity
Siegal, Deborah M, Curnutte, John T, Connolly, Stuart J, Lu, Genmin, Conley, Pamela B, Wiens, Brian L, Mathur, Vandana S, Castillo, Janice, Bronson, Michele D, Leeds, Janet M, Mar, Florie A, Gold, Alex, Crowther, Mark A
Published in The New England journal of medicine (17.12.2015)
Published in The New England journal of medicine (17.12.2015)
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Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model
Lu, Genmin, Pine, Polly, Leeds, Janet M, DeGuzman, Francis, Pratikhya, Pratikhya, Lin, Joyce, Malinowski, John, Hollenbach, Stanley J, Curnutte, John T, Conley, Pamela B
Published in PloS one (28.03.2018)
Published in PloS one (28.03.2018)
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Novel oral anticoagulants and reversal agents: Considerations for clinical development
Sarich, Troy C., PhD, Seltzer, Jonathan H., MD, Berkowitz, Scott D., MD, Costin', James, MD, Curnutte, John T., MD, Gibson, C. Michael, MD, Hoffman, Maureane, MD, PhD, Kaminskas, Edvardas, MD, Krucoff, Mitchell W., MD, Levy, Jerrold H., MD, Mintz, Paul D., MD, Reilly, Paul A., PhD, Sager, Philip T., MD, Singer, Daniel E., MD, Stockbridge, Norman, MD, PhD, Weitz, Jeffrey I., DM, Kowey, Peter R., MD
Published in The American heart journal (01.06.2015)
Published in The American heart journal (01.06.2015)
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Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa
Siegal, Deborah, Lu, Genmin, Leeds, Janet M., Karbarz, Mark, Castillo, Janice, Mathur, Vandana, Hutchaleelaha, Athiwat, Sinha, Uma, Kitt, Michael, McClure, Matt, Hollenbach, Stanley J., Curnutte, John T., Conley, Pamela B., Crowther, Mark
Published in Blood advances (26.09.2017)
Published in Blood advances (26.09.2017)
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Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors
Connolly, Stuart J, Crowther, Mark, Eikelboom, John W, Gibson, C. Michael, Curnutte, John T, Lawrence, John H, Yue, Patrick, Bronson, Michele D, Lu, Genmin, Conley, Pamela B, Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T, Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Demchuk, Andrew M, Pallin, Daniel J, Concha, Mauricio, Goodman, Shelly, Leeds, Janet, Souza, Sonia, Siegal, Deborah M, Zotova, Elena, Meeks, Brandi, Ahmad, Sadia, Nakamya, Juliet, Milling, Truman J
Published in The New England journal of medicine (04.04.2019)
Published in The New England journal of medicine (04.04.2019)
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Complement-Induced Impairment of Innate Immunity During Sepsis
Huber-Lang, Markus S, Younkin, Ellen M, Sarma, J. Vidya, McGuire, Stephanie R, Lu, Kristina T, Guo, Ren Feng, Padgaonkar, Vaishalee A, Curnutte, John T, Erickson, Richard, Ward, Peter A
Published in The Journal of immunology (1950) (15.09.2002)
Published in The Journal of immunology (1950) (15.09.2002)
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Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors
Connolly, Stuart J, Milling, Truman J, Eikelboom, John W, Gibson, C. Michael, Curnutte, John T, Gold, Alex, Bronson, Michele D, Lu, Genmin, Conley, Pamela B, Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T, Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Goodman, Shelly, Leeds, Janet, Wiens, Brian L, Siegal, Deborah M, Zotova, Elena, Meeks, Brandi, Nakamya, Juliet, Lim, W. Ting, Crowther, Mark
Published in The New England journal of medicine (22.09.2016)
Published in The New England journal of medicine (22.09.2016)
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Hemostatic Efficacy and Anti-FXa (Factor Xa) Reversal With Andexanet Alfa in Intracranial Hemorrhage: ANNEXA-4 Substudy
Demchuk, Andrew M, Yue, Patrick, Zotova, Elena, Nakamya, Juliet, Xu, Lizhen, Milling, Jr, Truman J, Ohara, Tomoyuki, Goldstein, Joshua N, Middeldorp, Saskia, Verhamme, Peter, Lopez-Sendon, Jose Luis, Conley, Pamela B, Curnutte, John T, Eikelboom, John W, Crowther, Mark, Connolly, Stuart J
Published in Stroke (1970) (01.06.2021)
Published in Stroke (1970) (01.06.2021)
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Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase
Walder, C E, Green, S P, Darbonne, W C, Mathias, J, Rae, J, Dinauer, M C, Curnutte, J T, Thomas, G R
Published in Stroke (1970) (01.11.1997)
Published in Stroke (1970) (01.11.1997)
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Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B-cell Malignancies
Coffey, Greg P, Feng, Jiajia, Betz, Andreas, Pandey, Anjali, Birrell, Matt, Leeds, Janet M, Der, Kenneth, Kadri, Sabah, Lu, Pin, Segal, Jeremy, Wang, Y Lynn, Michelson, Glenn, Curnutte, John T, Conley, Pamela B
Published in Clinical cancer research (15.02.2019)
Published in Clinical cancer research (15.02.2019)
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Andexanet versus prothrombin complex concentrates: Differences in reversal of factor Xa inhibitors in in vitro thrombin generation
Lu, Genmin, Lin, Joyce, Bui, Khanh, Curnutte, John T., Conley, Pamela B.
Published in Research and practice in thrombosis and haemostasis (01.11.2020)
Published in Research and practice in thrombosis and haemostasis (01.11.2020)
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Induction of gp91-phox, a Component of the Phagocyte NADPH Oxidase, in Microglial Cells during Central Nervous System Inflammation
Green, Simon P., Cairns, Belinda, Rae, Julie, Errett-Baroncini, Carol, Hongo, Jo-Anne S., Erickson, Richard W., Curnutte, John T.
Published in Journal of cerebral blood flow and metabolism (01.04.2001)
Published in Journal of cerebral blood flow and metabolism (01.04.2001)
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Focus on FOCIS: The continuing diagnostic challenge of autosomal recessive chronic granulomatous disease
Yu, Grace, Hong, David K, Dionis, Kira Y, Rae, Julie, Heyworth, Paul G, Curnutte, John T, Lewis, David B
Published in Clinical immunology (Orlando, Fla.) (01.08.2008)
Published in Clinical immunology (Orlando, Fla.) (01.08.2008)
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Chronic granulomatous disease
Heyworth, Paul G, Cross, Andrew R, Curnutte, John T
Published in Current opinion in immunology (01.10.2003)
Published in Current opinion in immunology (01.10.2003)
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Efficacy and safety of the dual SYK/JAK inhibitor cerdulatinib in patients with relapsed or refractory B‐cell malignancies: Results of a phase I study
Hamlin, Paul A., Flinn, Ian W., Wagner‐Johnston, Nina, Burger, Jan A., Coffey, Greg P., Conley, Pamela B., Michelson, Glenn, Leeds, Janet M., Der, Kenneth, Kim, Yvonne, Sabalvaro‐Torres, Alice, Birrell, Matt, Pandey, Anjali, Curnutte, John T., Patel, Manish R.
Published in American journal of hematology (01.04.2019)
Published in American journal of hematology (01.04.2019)
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Semi-automatic measurement of intracranial hemorrhage growth on non-contrast CT
Chung, Kevin J, Kuang, Hulin, Federico, Alyssa, Choi, Hyun Seok, Kasickova, Linda, Al Sultan, Abdulaziz Sulaiman, Horn, MacKenzie, Crowther, Mark, Connolly, Stuart J, Yue, Patrick, Curnutte, John T, Demchuk, Andrew M, Menon, Bijoy K, Qiu, Wu
Published in International journal of stroke (01.02.2021)
Published in International journal of stroke (01.02.2021)
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A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers
Lu, Genmin, Conley, Pamela B., Leeds, Janet M., Karbarz, Mark J., Levy, Gallia G., Mathur, Vandana S., Castillo, Janice, Crowther, Mark, Curnutte, John T.
Published in Blood advances (25.02.2020)
Published in Blood advances (25.02.2020)
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Andexanet Alfa Reverses Anticoagulation Effects of Enoxaparin and Associated Bleeding in a Rabbit Acute Hemorrhage Model
Pine, Polly, Lu, Genmin, Canivel, Deogracias, Pratikhya, Pratikhya, DeGuzman, Francis, Karbarz, Mark, Takeda, Kentaro, Malinowski, John, Leeds, Janet M., Curnutte, John T., Conley, Pamela B.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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