The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy
Francia, Valentina, Schiffelers, Raymond M, Cullis, Pieter R, Witzigmann, Dominik
Published in Bioconjugate chemistry (16.09.2020)
Published in Bioconjugate chemistry (16.09.2020)
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Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics
Kulkarni, Jayesh A, Witzigmann, Dominik, Chen, Sam, Cullis, Pieter R, van der Meel, Roy
Published in Accounts of chemical research (17.09.2019)
Published in Accounts of chemical research (17.09.2019)
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Journal Article
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery
Buck, Jonas, Grossen, Philip, Cullis, Pieter R, Huwyler, Jörg, Witzigmann, Dominik
Published in ACS nano (23.04.2019)
Published in ACS nano (23.04.2019)
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Journal Article
On the role of helper lipids in lipid nanoparticle formulations of siRNA
Kulkarni, Jayesh A, Witzigmann, Dominik, Leung, Jerry, Tam, Yuen Yi C, Cullis, Pieter R
Published in Nanoscale (21.11.2019)
Published in Nanoscale (21.11.2019)
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Journal Article
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Akinc, Akin, Maier, Martin A., Manoharan, Muthiah, Fitzgerald, Kevin, Jayaraman, Muthusamy, Barros, Scott, Ansell, Steven, Du, Xinyao, Hope, Michael J., Madden, Thomas D., Mui, Barbara L., Semple, Sean C., Tam, Ying K., Ciufolini, Marco, Witzigmann, Dominik, Kulkarni, Jayesh A., van der Meel, Roy, Cullis, Pieter R.
Published in Nature nanotechnology (01.12.2019)
Published in Nature nanotechnology (01.12.2019)
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Journal Article
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency
Cheng, Miffy Hok Yan, Leung, Jerry, Zhang, Yao, Strong, Colton, Basha, Genc, Momeni, Arash, Chen, Yihang, Jan, Eric, Abdolahzadeh, Amir, Wang, Xinying, Kulkarni, Jayesh A., Witzigmann, Dominik, Cullis, Pieter R.
Published in Advanced materials (Weinheim) (01.08.2023)
Published in Advanced materials (Weinheim) (01.08.2023)
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Journal Article
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
Kulkarni, Jayesh A, Darjuan, Maria M, Mercer, Joanne E, Chen, Sam, van der Meel, Roy, Thewalt, Jenifer L, Tam, Yuen Yi C, Cullis, Pieter R
Published in ACS nano (22.05.2018)
Published in ACS nano (22.05.2018)
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Journal Article
The cellular mechanisms of neuronal swelling underlying cytotoxic edema
Rungta, Ravi L, Choi, Hyun B, Tyson, John R, Malik, Aqsa, Dissing-Olesen, Lasse, Lin, Paulo J C, Cain, Stuart M, Cullis, Pieter R, Snutch, Terrance P, MacVicar, Brian A
Published in Cell (23.04.2015)
Published in Cell (23.04.2015)
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Journal Article
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
Jayaraman, Muthusamy, Ansell, Steven M., Mui, Barbara L., Tam, Ying K., Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K., Rajeev, Kallanthottathil G., Hafez, Ismail M., Akinc, Akin, Maier, Martin A., Tracy, Mark A., Cullis, Pieter R., Madden, Thomas D., Manoharan, Muthiah, Hope, Michael J.
Published in Angewandte Chemie (International ed.) (20.08.2012)
Published in Angewandte Chemie (International ed.) (20.08.2012)
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Journal Article
Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads
Kulkarni, Jayesh A, Witzigmann, Dominik, Leung, Jerry, van der Meel, Roy, Zaifman, Josh, Darjuan, Maria M, Grisch-Chan, Hiu Man, Thöny, Beat, Tam, Yuen Yi C, Cullis, Pieter R
Published in Nanoscale (01.01.2019)
Published in Nanoscale (01.01.2019)
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Journal Article
Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core
Leung, Alex K. K, Hafez, Ismail M, Baoukina, Svetlana, Belliveau, Nathan M, Zhigaltsev, Igor V, Afshinmanesh, Elham, Tieleman, D. Peter, Hansen, Carl L, Hope, Michael J, Cullis, Pieter R
Published in Journal of physical chemistry. C (30.08.2012)
Published in Journal of physical chemistry. C (30.08.2012)
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Journal Article
Exciting Times for Lipid Nanoparticles: How Canadian Discoveries Are Enabling Gene Therapies
Cheng, Miffy H. Y., Brimacombe, Cedric A., Verbeke, Rein, Cullis, Pieter R.
Published in Molecular pharmaceutics (06.06.2022)
Published in Molecular pharmaceutics (06.06.2022)
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Journal Article
Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles
Kulkarni, Jayesh A, Thomson, Sarah B, Zaifman, Josh, Leung, Jerry, Wagner, Pamela K, Hill, Austin, Tam, Yuen Yi C, Cullis, Pieter R, Petkau, Terri L, Leavitt, Blair R
Published in Nanoscale (21.12.2020)
Published in Nanoscale (21.12.2020)
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Journal Article
Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration
Chen, Sam, Tam, Yuen Yi C., Lin, Paulo J.C., Leung, Alex K.K., Tam, Ying K., Cullis, Pieter R.
Published in Journal of controlled release (28.12.2014)
Published in Journal of controlled release (28.12.2014)
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Journal Article
Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues
Chander, Nisha, Basha, Genc, Yan Cheng, Miffy Hok, Witzigmann, Dominik, Cullis, Pieter R.
Published in Molecular therapy. Methods & clinical development (14.09.2023)
Published in Molecular therapy. Methods & clinical development (14.09.2023)
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Journal Article
Robust Microfluidic Technology and New Lipid Composition for Fabrication of Curcumin-Loaded Liposomes: Effect on the Anticancer Activity and Safety of Cisplatin
Hamano, Nobuhito, Böttger, Roland, Lee, Suen Ern, Yang, Yang, Kulkarni, Jayesh A, Ip, Shell, Cullis, Pieter R, Li, Shyh-Dar
Published in Molecular pharmaceutics (03.09.2019)
Published in Molecular pharmaceutics (03.09.2019)
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Journal Article
Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids
Chen, Sam, Zaifman, Josh, Kulkarni, Jayesh A., Zhigaltsev, Igor V., Tam, Ying K., Ciufolini, Marco A., Tam, Yuen Yi C., Cullis, Pieter R.
Published in Journal of controlled release (28.09.2018)
Published in Journal of controlled release (28.09.2018)
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