A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator
Heijer, Jonas M., Kruithof, Annelieke C., Amerongen, Guido, Kam, Marieke L., Thijssen, Eva, Grievink, Hendrika W., Moerland, Matthijs, Walker, Mike, Been, Kees, Skerlj, Renato, Justman, Craig, Dudgeon, Lindsay, Lansbury, Peter, Cullen, Valerie C., Hilt, Dana C., Groeneveld, Geert Jan
Published in British journal of clinical pharmacology (01.09.2021)
Published in British journal of clinical pharmacology (01.09.2021)
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A Biomarker Study in Patients with GBA1‐Parkinson's Disease and Healthy Controls
Heijer, Jonas M., Cullen, Valerie C., Pereira, Diana R., Yavuz, Yalcin, Kam, Marieke L., Grievink, Hendrika W., Moerland, Matthijs, Leymarie, Nancy, Khatri, Kshitij, Sollomoni, Imelda, Spitalny, Leslie, Dungeon, Lindsay, Hilt, Dana C., Justman, Craig, Lansbury, Peter, Groeneveld, Geert Jan
Published in Movement disorders (01.05.2023)
Published in Movement disorders (01.05.2023)
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A Phase 1B Trial in GBA1‐Associated Parkinson's Disease of BIA‐28‐6156, a Glucocerebrosidase Activator
Heijer, Jonas M., Kruithof, Annelieke C., Moerland, Matthijs, Walker, Mike, Dudgeon, Lindsay, Justman, Craig, Solomini, Imelda, Splitalny, Leslie, Leymarie, Nancy, Khatri, Kshitij, Cullen, Valerie C., Hilt, Dana C., Groeneveld, Geert Jan, Lansbury, Peter
Published in Movement disorders (01.07.2023)
Published in Movement disorders (01.07.2023)
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Journal Article
A Large‐Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands
Heijer, Jonas M., Cullen, Valerie C., Quadri, Marialuisa, Schmitz, Arnoud, Hilt, Dana C., Lansbury, Peter, Berendse, Henk W., Berg, Wilma D.J., Bie, Rob M.A., Boertien, Jeffrey M., Boon, Agnita J.W., Contarino, M. Fiorella, Hilten, Jacobus J., Hoff, Jorrit I., Mierlo, Tom, Munts, Alex G., Plas, Anne A., Ponsen, Mirthe M., Baas, Frank, Majoor‐Krakauer, Danielle, Bonifati, Vincenzo, Laar, Teus, Groeneveld, Geert J.
Published in Movement disorders (01.09.2020)
Published in Movement disorders (01.09.2020)
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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
Cullen, Valerie, Lindfors, Maria, Ng, Juliana, Paetau, Anders, Swinton, Erika, Kolodziej, Piotr, Boston, Heather, Saftig, Paul, Woulfe, John, Feany, Mel B, Myllykangas, Liisa, Schlossmacher, Michael G, Tyynelä, Jaana
Published in Molecular brain (09.02.2009)
Published in Molecular brain (09.02.2009)
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The Small Molecule Aldehyde Trap NS2 Exhibits Potent Anti-Inflammatory Activity in Three Murine Models of Inflammation
Cullen, Valerie C., PhD, Mechanic, Jordan, PhD, Welihinda, Ajith, PhD, Young, Scott L., BS, Amento, Edward P., MD, PhD
Published in Journal of allergy and clinical immunology (01.02.2015)
Published in Journal of allergy and clinical immunology (01.02.2015)
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Gigaxonin is associated with the Golgi and dimerises via its BTB domain
Cullen, Valerie C, Brownlees, Janet, Banner, Steven, Anderton, Brian H, Leigh, P Nigel, Shaw, Christopher E, Miller, Christopher C J
Published in Neuroreport (09.04.2004)
Published in Neuroreport (09.04.2004)
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Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing
Cullen, Valerie, Sardi, S. Pablo, Ng, Juliana, Xu, You-Hai, Sun, Ying, Tomlinson, Julianna J., Kolodziej, Piotr, Kahn, Ilana, Saftig, Paul, Woulfe, John, Rochet, Jean-Christophe, Glicksman, Marcie A., Cheng, Seng H., Grabowski, Gregory A., Shihabuddin, Lamya S., Schlossmacher, Michael G.
Published in Annals of neurology (01.06.2011)
Published in Annals of neurology (01.06.2011)
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Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
Mollenhauer, Brit, Cullen, Valerie, Kahn, Ilana, Krastins, Bryan, Outeiro, Tiago F., Pepivani, Imelda, Ng, Juliana, Schulz-Schaeffer, Walter, Kretzschmar, Hans A., McLean, Pamela J., Trenkwalder, Claudia, Sarracino, David A., VonSattel, Jean-Paul, Locascio, Joseph J., El-Agnaf, Omar M.A., Schlossmacher, Michael G.
Published in Experimental neurology (01.10.2008)
Published in Experimental neurology (01.10.2008)
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Journal Article
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice
Levenson, Jonathan M, Schroeter, Sally, Carroll, Jenna C, Cullen, Valerie, Asp, Eva, Proschitsky, Ming, Chung, Charlotte H.-Y, Gilead, Sharon, Nadeem, Muhammad, Dodiya, Hemraj B, Shoaga, Shadiyat, Mufson, Elliott J, Tsubery, Haim, Krishnan, Rajaraman, Wright, Jason, Solomon, Beka, Fisher, Richard, Gannon, Kimberley S
Published in Alzheimer's & dementia : translational research & clinical interventions (01.09.2016)
Published in Alzheimer's & dementia : translational research & clinical interventions (01.09.2016)
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TREATMENT OF SYNUCLEINOPATHIES
SHIHABUDDIN LAMYA, CULLEN VALERIE, SCHLOSSMACHER MICHAEL, CHENG SENG H
Year of Publication 20.04.2017
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Year of Publication 20.04.2017
Patent
The Glucocerebrosidase Gene and Parkinson's Disease in Ashkenazi Jews
Eblan, Michael J, Walker, Jamie M, Sidransky, Ellen
Published in The New England journal of medicine (17.02.2005)
Published in The New England journal of medicine (17.02.2005)
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TREATMENT OF SYNUCLEINOPATHIES
SHIHABUDDIN LAMYA, CULLEN VALERIE, SCHLOSSMACHER MICHAEL, CHENG SENG H
Year of Publication 31.03.2016
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Year of Publication 31.03.2016
Patent
P4‐213: REDUCTION OF β‐AMYLOID AND PHOSPHO‐TAU IN TRANSGENIC MICE BY A NOVEL FUSION PROTEIN BIVALENT FOR A GENERAL AMYLOID INTERACTION MOTIF (GAIM)
Levenson, Jonathan M., Asp, Eva, Carroll, Jenna, Cullen, Valerie, Dodiya, Hemraj, Proschitsky, Ming, Mufson, Elliott Jay, Nadeem, Muhammad, Schroeter, Sally, Shoaga, Shadiyat, Tsubery, Haim, Krishnan, Rajaraman, Solomon, Beka, Fisher, Richard Alan, Gannon, Kimberley S.
Published in Alzheimer's & dementia (01.07.2014)
Published in Alzheimer's & dementia (01.07.2014)
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Journal Article
REDUCTION OF β-AMYLOID AND PHOSPHO-TAU IN TRANSGENIC MICE BY A NOVEL FUSION PROTEIN BIVALENT FOR A GENERAL AMYLOID INTERACTION MOTIF (GAIM)
Levenson, Jonathan M, Asp, Eva, Carroll, Jenna, Cullen, Valerie, Dodiya, Hemraj, Proschitsky, Ming, Mufson, Elliott Jay, Nadeem, Muhammad, Schroeter, Sally, Shoaga, Shadiyat, Tsubery, Haim, Krishnan, Rajaraman, Solomon, Beka, Fisher, Richard Alan, Gannon, Kimberley S
Published in Alzheimer's & dementia (01.07.2014)
Published in Alzheimer's & dementia (01.07.2014)
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Journal Article
O1‐05‐01: Discovery, preclinical development, and clinical trial approach for npt088, a general amyloid interaction motif (GAIM)‐immunoglobulin fusion
Fisher, Richard A., Gannon, Kimberley S., Krishnan, Rajaraman, Levenson, Jonathan M., Tsubery, Haim, Asp, Eva, Carroll, Jenna C., Cullen, Valerie, Gartner, Myra, Gilead, Sharon, Gray, Michelle, Grundman, Michael, Hefti, Franz, Lulu, Michal, Masliah, Eliezer, Mufson, Elliott, Nadeem, Muhamad, Proschitsky, Ming, Rockenstien, Edward, Schroeter, Sally, Solomon, Beka, Wright, Jason S.
Published in Alzheimer's & dementia (01.07.2015)
Published in Alzheimer's & dementia (01.07.2015)
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Journal Article
Discovery, preclinical development, and clinical trial approach for npt088, a general amyloid interaction motif (GAIM)-immunoglobulin fusion
Fisher, Richard A, Gannon, Kimberley S, Krishnan, Rajaraman, Levenson, Jonathan M, Tsubery, Haim, Asp, Eva, Carroll, Jenna C, Cullen, Valerie, Gartner, Myra, Gilead, Sharon, Gray, Michelle, Grundman, Michael, Hefti, Franz, Lulu, Michal, Masliah, Eliezer, Mufson, Elliott, Nadeem, Muhamad, Proschitsky, Ming, Rockenstien, Edward, Schroeter, Sally, Solomon, Beka, Wright, Jason S
Published in Alzheimer's & dementia (01.07.2015)
Published in Alzheimer's & dementia (01.07.2015)
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IMMUNOGLOBULIN-GENERAL AMYLOID INTERACTION MOTIF (IG-GAIM) MOLECULES TARGET BETA AMYLOID AND NEUROFIBRILLARY TANGLES IN VITRO AND IN VIVO
Tsubery, Haim, Krishnan, Rajaraman, Proschitsky, Ming, Asp, Eva, Lulu, Michal, Gilead, Sharon, Gartner, Myra, Gannon, Kimberley S, Levenson, Jonathan M, Schroeter, Sally, Cullen, Valerie, Carroll, Jenna, Wright, Jason, Solomon, Beka, Myszka, David, Masliah, Eliezer, Rockenstein, Edward, Waltho, Jonathon, Davis, Peter, Mufson, Elliott Jay, Nadeem, Muhammad, Fisher, Richard Alan
Published in Alzheimer's & dementia (01.07.2014)
Published in Alzheimer's & dementia (01.07.2014)
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