An Enantiomer of an Oral Small-Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties
Neumann, Susanne, Padia, Umesh, Cullen, Mary Jane, Eliseeva, Elena, Nir, Eshel A, Place, Robert F, Morgan, Sarah J, Gershengorn, Marvin C
Published in Frontiers in endocrinology (Lausanne) (27.07.2016)
Published in Frontiers in endocrinology (Lausanne) (27.07.2016)
Get full text
Journal Article
Role of Corticotropin-Releasing Factor (CRF) Receptors in the Anorexic Syndrome Induced by CRF
Pelleymounter, M A, Joppa, M, Carmouche, M, Cullen, M J, Brown, B, Murphy, B, Grigoriadis, D E, Ling, N, Foster, A C
Published in The Journal of pharmacology and experimental therapeutics (01.06.2000)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.06.2000)
Journal Article
In Vivo Pharmacological Characterization of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic
Foster, Alan C, Pelleymounter, Mary Ann, Cullen, Mary Jane, Lewis, Dacie, Joppa, Margaret, Chen, Ta Kung, Bozigian, Haig P, Gross, Raymond S, Gogas, Kathleen R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2004)
Get full text
Journal Article
Systemically and Topically Administered Leptin Both Accelerate Wound Healing in Diabetic ob/ob Mice
Ring, Brian D, Scully, Sheila, Davis, Corrine R, Baker, Mary Beth, Cullen, Mary Jane, Pelleymounter, Mary Ann, Danilenko, Dimitry M
Published in Endocrinology (Philadelphia) (01.01.2000)
Published in Endocrinology (Philadelphia) (01.01.2000)
Get full text
Journal Article
Characteristics of BDNF-induced weight loss
Pelleymounter, Mary Ann, Cullen, Mary Jane, Wellman, Cara L.
Published in Experimental neurology (01.02.1995)
Published in Experimental neurology (01.02.1995)
Get full text
Journal Article
Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders
Meng, Wei, Brigance, Robert, Mignone, James, Negash, Lidet, Zhao, Guohua, Ahmad, Saleem, Wang, Wei, Moore, Fang, Ye, Xiang-Yang, Sun, Jung-Hui, Mathur, Arvind, Li, Yi-Xin, Azzara, Anthony, Ma, Zhengping, Chu, Ching-Hsuen, Cullen, Mary Jane, Rooney, Suzanne, Harvey, Susan, Kopcho, Lisa, Abell, Lynn, O’Malley, Kevin, Keim, William, Dierks, Elizabeth A., Chang, Shu, Foster, Kimberly A., Harden, David, Dabros, Marta, Goti, Vineet, De Oliveira, Claudia, Krishna, Gopal, Pelleymounter, Mary Ann, Whaley, Jean, Robl, Jeffrey A., Cheng, Dong, Devasthale, Pratik
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
Get full text
Journal Article
Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders
Moore, Fang, Wang, Wei, Zhao, Guohua, Mignone, James, Meng, Wei, Chu, Ching-Hsuen, Ma, Zhengping, Azzara, Anthony, Cullen, Mary Jane, Pelleymounter, Mary Ann, Appiah, Kingsley, Cvijic, Mary Ellen, Dierks, Elizabeth, Chang, Shu, Foster, Kimberly, Kopcho, Lisa, O'Malley, Kevin, Li, Yi-Xin, Khandelwal, Purnima, Whaley, Jean M., Mathur, Arvind, Hou, Xiaoping, Wu, Dauh-Rurng, Robl, Jeffrey A., Cheng, Dong, Devasthale, Pratik
Published in Bioorganic & medicinal chemistry letters (15.07.2023)
Published in Bioorganic & medicinal chemistry letters (15.07.2023)
Get full text
Journal Article
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders
Turdi, Huji, Chao, Hannguang, Hangeland, Jon J, Ahmad, Saleem, Meng, Wei, Brigance, Robert, Zhao, Guohua, Wang, Wei, Moore, Fang, Ye, Xiang-Yang, Mathur, Arvind, Hou, Xiaoping, Kempson, James, Wu, Dauh-Rurng, Li, Yi-Xin, Azzara, Anthony V, Ma, Zhengping, Chu, Ching-Hsuen, Chen, Luping, Cullen, Mary Jane, Rooney, Suzanne, Harvey, Susan, Kopcho, Lisa, Panemangelor, Reshma, Abell, Lynn, O’Malley, Kevin, Keim, William J, Dierks, Elizabeth, Chang, Shu, Foster, Kimberly, Apedo, Atsu, Harden, David, Dabros, Marta, Gao, Qi, Pelleymounter, Mary Ann, Whaley, Jean M, Robl, Jeffrey A, Cheng, Dong, Lawrence, R. Michael, Devasthale, Pratik
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
Get full text
Journal Article
Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5‑HT2C Receptor Agonists
Carpenter, Joseph, Wang, Ying, Wu, Gang, Feng, Jianxin, Ye, Xiang-Yang, Morales, Christian L, Broekema, Matthias, Rossi, Karen A, Miller, Keith J, Murphy, Brian J, Wu, Ginger, Malmstrom, Sarah E, Azzara, Anthony V, Sher, Philip M, Fevig, John M, Alt, Andrew, Bertekap, Robert L, Cullen, Mary Jane, Harper, Timothy M, Foster, Kimberly, Luk, Emily, Xiang, Qian, Grubb, Mary F, Robl, Jeffrey A, Wacker, Dean A
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
Get full text
Journal Article
Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT 2C Receptor Agonists
Carpenter, Joseph, Wang, Ying, Wu, Gang, Feng, Jianxin, Ye, Xiang-Yang, Morales, Christian L, Broekema, Matthias, Rossi, Karen A, Miller, Keith J, Murphy, Brian J, Wu, Ginger, Malmstrom, Sarah E, Azzara, Anthony V, Sher, Philip M, Fevig, John M, Alt, Andrew, Bertekap, Jr, Robert L, Cullen, Mary Jane, Harper, Timothy M, Foster, Kimberly, Luk, Emily, Xiang, Qian, Grubb, Mary F, Robl, Jeffrey A, Wacker, Dean A
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
Get full text
Journal Article
Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies
Devasthale, Pratik, Wang, Wei, Mignone, James, Renduchintala, Kishore, Radhakrishnan, Sridhar, Dhanapal, Jayanthi, Selvaraj, Jagannath, Kuppusamy, Rajesh, Pelleymounter, Mary Ann, Longhi, Daniel, Huang, Ning, Flynn, Neil, Azzara, Anthony V., Rohrbach, Kenneth, Devenny, James, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen, Harvey, Susan, Cullen, Mary Jane, Zhang, Hongwei, Caporuscio, Christian, Stetsko, Paul, Grubb, Mary, Huang, Christine, Zhang, Lisa, Freeden, Chris, Murphy, Brian J., Robl, Jeffrey A., Washburn, William N.
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Get full text
Journal Article
Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate
Washburn, William N, Manfredi, Mark, Devasthale, Pratik, Zhao, Guohua, Ahmad, Saleem, Hernandez, Andres, Robl, Jeffrey A, Wang, Wei, Mignone, James, Wang, Zhenghua, Ngu, Khehyong, Pelleymounter, Mary Ann, Longhi, Daniel, Zhao, Rulin, Wang, Bei, Huang, Ning, Flynn, Neil, Azzara, Anthony V, Barrish, Joel C, Rohrbach, Kenneth, Devenny, James J, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen E, Harvey, Susan J, Cullen, Mary Jane, Zhang, Hongwei, Caporuscio, Christian, Stetsko, Paul, Grubb, Mary, Maxwell, Brad D, Yang, Hong, Apedo, Atsu, Gemzik, Brian, Janovitz, Evan B, Huang, Christine, Zhang, Lisa, Freeden, Chris, Murphy, Brian J
Published in Journal of medicinal chemistry (25.09.2014)
Published in Journal of medicinal chemistry (25.09.2014)
Get full text
Journal Article
Urocortin, Corticotropin Releasing Factor-2 Receptors and Energy Balance
Cullen, Mary Jane, Ling, Nick, Foster, Alan C, Pelleymounter, Mary Ann
Published in Endocrinology (Philadelphia) (01.03.2001)
Published in Endocrinology (Philadelphia) (01.03.2001)
Get full text
Journal Article
Effects of the obese gene product on body weight regulation in ob/ob mice
Pelleymounter, M.A. (Amgen, Inc., Thousand Oaks, CA.), Cullen, M.J, Baker, M.B, Hecht, R, Winters, D, Boone, T, Collins, F
Published in Science (American Association for the Advancement of Science) (28.07.1995)
Published in Science (American Association for the Advancement of Science) (28.07.1995)
Get full text
Journal Article
Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup
Devasthale, Pratik, Wang, Wei, Hernandez, Andres S., Moore, Fang, Renduchintala, Kishore, Sridhar, Radhakrishnan, Pelleymounter, Mary Ann, Longhi, Daniel, Huang, Ning, Flynn, Neil, Azzara, Anthony V., Rohrbach, Kenneth, Devenny, James, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen, Harvey, Susan, Cullen, Mary Jane, Zhang, Hongwei, Caporuscio, Christian, Stetsko, Paul, Grubb, Mary, Huang, Christine, Zhang, Lisa, Freeden, Chris, Li, Yi-Xin, Murphy, Brian J., Robl, Jeffrey A., Washburn, William N.
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
Get full text
Journal Article
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists
Fevig, John M., Feng, Jianxin, Rossi, Karen A., Miller, Keith J., Wu, Ginger, Hung, Chen-Pin, Ung, Thao, Malmstrom, Sarah E., Zhang, Ge, Keim, William J., Cullen, Mary Jane, Rohrbach, Kenneth W., Qu, Qinling, Gan, Jinping, Pelleymounter, Mary Ann, Robl, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Get full text
Journal Article
Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT2C receptor agonists
Zhao, Guohua, Kwon, Chet, Bisaha, Sharon N., Stein, Philip D., Rossi, Karen A., Cao, Xueying, Ung, Thao, Wu, Ginger, Hung, Chen-Pin, Malmstrom, Sarah E., Zhang, Ge, Qu, Qinling, Gan, Jinping, Keim, William J., Cullen, Mary Jane, Rohrbach, Kenneth W., Devenny, James, Pelleymounter, Mary Ann, Miller, Keith J., Robl, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Get full text
Journal Article
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
Qu, Daqing, Ludwig, David S, Gammeltoft, Steen, Piper, Megan, Pelleymounter, Mary Ann, Cullen, Mary Jane, Mathes, Wendy Foulds, Przypek, Jeanne, Kanarek, Robin, Maratos-Flier, Eleftheria
Published in Nature (London) (21.03.1996)
Published in Nature (London) (21.03.1996)
Get full text
Journal Article
Reductions in log P Improved Protein Binding and Clearance Predictions Enabling the Prospective Design of Cannabinoid Receptor (CB1) Antagonists with Desired Pharmacokinetic Properties
Ellsworth, Bruce A, Sher, Philip M, Wu, Ximao, Wu, Gang, Sulsky, Richard B, Gu, Zhengxiang, Murugesan, Natesan, Zhu, Yeheng, Yu, Guixue, Sitkoff, Doree F, Carlson, Kenneth E, Kang, Liya, Yang, Yifan, Lee, Ning, Baska, Rose A, Keim, William J, Cullen, Mary Jane, Azzara, Anthony V, Zuvich, Eva, Thomas, Michael A, Rohrbach, Kenneth W, Devenny, James J, Godonis, Helen E, Harvey, Susan J, Murphy, Brian J, Everlof, Gerry G, Stetsko, Paul I, Gudmundsson, Olafur, Johnghar, Susan, Ranasinghe, Asoka, Behnia, Kamelia, Pelleymounter, Mary Ann, Ewing, William R
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
Get full text
Journal Article
Discovery of ( R )-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1- a ]isoindol- 6(2 H )-one, a Selective, Orally Active Agonist of the 5-HT 2C Receptor
Wacker, Dean A., Varnes, Jeffrey G., Malmstrom, Sarah E., Cao, Xueying, Hung, Chen-Pin, Ung, Thao, Wu, Ginger, Zhang, Ge, Zuvich, Eva, Thomas, Michael A., Keim, William J., Cullen, Mary Jane, Rohrbach, Kenneth W., Qu, Qinling, Narayanan, Rangaraj, Rossi, Karen, Janovitz, Evan, Lehman-McKeeman, Lois, Malley, Mary F., Devenny, James, Pelleymounter, Mary Ann, Miller, Keith J., Robl, Jeffrey A.
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article