CCT complex restricts neuropathogenic protein aggregation via autophagy
Pavel, Mariana, Imarisio, Sara, Menzies, Fiona M., Jimenez-Sanchez, Maria, Siddiqi, Farah H., Wu, Xiaoting, Renna, Maurizio, O’Kane, Cahir J., Crowther, Damian C., Rubinsztein, David C.
Published in Nature communications (08.12.2016)
Published in Nature communications (08.12.2016)
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ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
Bolognesi, Benedetta, Kumita, Janet R., Barros, Teresa P., Esbjorner, Elin K., Luheshi, Leila M., Crowther, Damian C., Wilson, Mark R., Dobson, Christopher M., Favrin, Giorgio, Yerbury, Justin J.
Published in ACS chemical biology (20.08.2010)
Published in ACS chemical biology (20.08.2010)
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TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant
Thornton, Peter, Sevalle, Jean, Deery, Michael J, Fraser, Graham, Zhou, Ye, Ståhl, Sara, Franssen, Elske H, Dodd, Roger B, Qamar, Seema, Gomez Perez‐Nievas, Beatriz, Nicol, Louise SC, Eketjäll, Susanna, Revell, Jefferson, Jones, Clare, Billinton, Andrew, St George‐Hyslop, Peter H, Chessell, Iain, Crowther, Damian C
Published in EMBO molecular medicine (01.10.2017)
Published in EMBO molecular medicine (01.10.2017)
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Journal Article
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, Ruchi, Chen, Ko-Fan, Kent, Brianne A, Crowther, Damian C
Published in Disease models & mechanisms (01.10.2017)
Published in Disease models & mechanisms (01.10.2017)
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Journal Article
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Xia, Zengjie, Prescott, Emily E., Urbanek, Agnieszka, Wareing, Hollie E., King, Marianne C., Olerinyova, Anna, Dakin, Helen, Leah, Tom, Barnes, Katy A., Matuszyk, Martyna M., Dimou, Eleni, Hidari, Eric, Zhang, Yu P., Lam, Jeff Y. L., Danial, John S. H., Strickland, Michael R., Jiang, Hong, Thornton, Peter, Crowther, Damian C., Ohtonen, Sohvi, Gómez-Budia, Mireia, Bell, Simon M., Ferraiuolo, Laura, Mortiboys, Heather, Higginbottom, Adrian, Wharton, Stephen B., Holtzman, David M., Malm, Tarja, Ranasinghe, Rohan T., Klenerman, David, De, Suman
Published in Nature communications (01.06.2024)
Published in Nature communications (01.06.2024)
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Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins
Kroeger, Heike, Miranda, Elena, MacLeod, Ian, Pérez, Juan, Crowther, Damian C., Marciniak, Stefan J., Lomas, David A.
Published in The Journal of biological chemistry (21.08.2009)
Published in The Journal of biological chemistry (21.08.2009)
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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity
Luheshi, Leila M, Tartaglia, Gian Gaetano, Brorsson, Ann-Christin, Pawar, Amol P, Watson, Ian E, Chiti, Fabrizio, Vendruscolo, Michele, Lomas, David A, Dobson, Christopher M, Crowther, Damian C
Published in PLoS biology (30.10.2007)
Published in PLoS biology (30.10.2007)
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The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans
Khabirova, Eleonora, Moloney, Aileen, Marciniak, Stefan J, Williams, Julie, Lomas, David A, Oliver, Stephen G, Favrin, Giorgio, Sattelle, David B, Crowther, Damian C
Published in PloS one (31.07.2014)
Published in PloS one (31.07.2014)
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Journal Article
p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress
Thomas, Sally E., Malzer, Elke, Ordóñez, Adriana, Dalton, Lucy E., van ′t Wout, Emily F.A., Liniker, Elizabeth, Crowther, Damian C., Lomas, David A., Marciniak, Stefan J.
Published in The Journal of biological chemistry (15.03.2013)
Published in The Journal of biological chemistry (15.03.2013)
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Journal Article
Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival
Thackray, Alana M, Muhammad, Farooq, Zhang, Chang, Di, Ying, Jahn, Thomas R, Landgraf, Matthias, Crowther, Damian C, Evers, Jan Felix, Bujdoso, Raymond
Published in Biochemical journal (15.06.2012)
Published in Biochemical journal (15.06.2012)
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Journal Article
Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response
Malzer, Elke, Daly, Marie-Louise, Moloney, Aileen, Sendall, Timothy J, Thomas, Sally E, Ryder, Edward, Ryoo, Hyung Don, Crowther, Damian C, Lomas, David A, Marciniak, Stefan J
Published in Journal of cell science (01.09.2010)
Published in Journal of cell science (01.09.2010)
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Journal Article
Mutant Neuroserpin (S49P) That Causes Familial Encephalopathy with Neuroserpin Inclusion Bodies Is a Poor Proteinase Inhibitor and Readily Forms Polymers in Vitro
Belorgey, Didier, Crowther, Damian C., Mahadeva, Ravi, Lomas, David A.
Published in The Journal of biological chemistry (10.05.2002)
Published in The Journal of biological chemistry (10.05.2002)
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Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease
Younan, Nadine D., Chen, Ko-Fan, Rose, Ruth-Sarah, Crowther, Damian C., Viles, John H.
Published in The Journal of biological chemistry (24.08.2018)
Published in The Journal of biological chemistry (24.08.2018)
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Journal Article
Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation
Liu, Beinan, Moloney, Aileen, Meehan, Sarah, Morris, Kyle, Thomas, Sally E., Serpell, Louise C., Hider, Robert, Marciniak, Stefan J., Lomas, David A., Crowther, Damian C.
Published in The Journal of biological chemistry (11.02.2011)
Published in The Journal of biological chemistry (11.02.2011)
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Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting
Fabre, Kristin M., Delsing, Louise, Hicks, Ryan, Colclough, Nicola, Crowther, Damian C., Ewart, Lorna
Published in Advanced drug delivery reviews (01.02.2019)
Published in Advanced drug delivery reviews (01.02.2019)
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