Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1
Schnute, Mark E, McReynolds, Matthew D, Kasten, Tom, Yates, Matthew, Jerome, Gina, Rains, John W, Hall, Troii, Chrencik, Jill, Kraus, Michelle, Cronin, Ciaran N, Saabye, Matthew, Highkin, Maureen K, Broadus, Richard, Ogawa, Shinji, Cukyne, Kristin, Zawadzke, Laura E, Peterkin, Vincent, Iyanar, Kaliapan, Scholten, Jeffrey A, Wendling, Jay, Fujiwara, Hideji, Nemirovskiy, Olga, Wittwer, Arthur J, Nagiec, Marek M
Published in Biochemical journal (15.05.2012)
Published in Biochemical journal (15.05.2012)
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Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers
Qiu, Luping, Levine, Kymberly, Gajiwala, Ketan S, Cronin, Ciarán N, Nagata, Asako, Johnson, Eric, Kraus, Michelle, Tatlock, John, Kania, Robert, Foley, Timothy, Sun, Shaoxian
Published in PloS one (07.06.2018)
Published in PloS one (07.06.2018)
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Journal Article
Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain
Bagal, Sharan K, Andrews, Mark, Bechle, Bruce M, Bian, Jianwei, Bilsland, James, Blakemore, David C, Braganza, John F, Bungay, Peter J, Corbett, Matthew S, Cronin, Ciaran N, Cui, Jingrong Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, James, Kim, Johnson, Eric, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Ninkovic, Sacha, Omoto, Kiyoyuki, Scales, Stephanie, Skerratt, Sarah E, Sun, Jianmin, Tran-Dubé, Michelle, Waldron, Gareth J, Wang, Fen, Warmus, Joseph S
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Journal Article
Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays
Hofler, Alexandra, Nichols, Tim, Grant, Stephan, Lingardo, Laura, Esposito, Edward A., Gridley, Scott, Murphy, Sean T., Kath, John C., Cronin, Ciarán N., Kraus, Michelle, Alton, Gordon, Xie, Zhi, Sutton, Scott, Gehring, Mike, Ermolieff, Jacques
Published in Analytical biochemistry (15.07.2011)
Published in Analytical biochemistry (15.07.2011)
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Journal Article
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
LOVE, Robert A, BRODSKY, Oleg, HICKEY, Michael J, WELLS, Peter A, CRONIN, Ciaran N
Published in Journal of Virology (01.05.2009)
Published in Journal of Virology (01.05.2009)
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Journal Article
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
Pemovska, Tea, Johnson, Eric, Kontro, Mika, Repasky, Gretchen A, Chen, Jeffrey, Wells, Peter, Cronin, Ciarán N, McTigue, Michele, Kallioniemi, Olli, Porkka, Kimmo, Murray, Brion W, Wennerberg, Krister
Published in Nature (London) (05.03.2015)
Published in Nature (London) (05.03.2015)
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Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Journal Article
Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors
Bagal, Sharan K, Omoto, Kiyoyuki, Blakemore, David C, Bungay, Peter J, Bilsland, James G, Clarke, Philip J, Corbett, Matthew S, Cronin, Ciaran N, Cui, J. Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, Johnson, Eric, Fengas, David, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Waldron, Gareth J, Warmus, Joseph S
Published in Journal of medicinal chemistry (10.01.2019)
Published in Journal of medicinal chemistry (10.01.2019)
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Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation
Johnson, Eric, McTigue, Michele, Gallego, Rebecca A., Johnson, Ted W., Timofeevski, Sergei, Maestre, Michael, Fisher, Timothy S., Kania, Robert, Sawasdikosol, Sansana, Burakoff, Steven, Cronin, Ciarán N.
Published in The Journal of biological chemistry (07.06.2019)
Published in The Journal of biological chemistry (07.06.2019)
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Journal Article
Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs
Subash, Sandhya, Singh, Dilip K, Ahire, Deepak S, Khojasteh, S Cyrus, Murray, Bernard P, Zientek, Michael A, Jones, Robert S, Kulkarni, Priyanka, Smith, Bill J, Heyward, Scott, Cronin, Ciarán N, Prasad, Bhagwat
Published in Drug metabolism and disposition (01.10.2023)
Published in Drug metabolism and disposition (01.10.2023)
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Journal Article
Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay
Cronin, Ciarán N., Liu, JianHua, Grable, Nicole, Strelevitz, Timothy J., Obach, R. Scott, Carlo, Anthony
Published in Protein expression and purification (01.01.2021)
Published in Protein expression and purification (01.01.2021)
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Journal Article
Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase
Choi, Chulho, Carlo, Anthony A, Cronin, Ciarán N, Jing, Konghua, Kung, Daniel W, Liu, Jianhua, Lombardo, Vincent M, Turco, Abigail R, Yin, Juxing, Yu, Aijia, Wright, Stephen W
Published in ACS medicinal chemistry letters (10.02.2022)
Published in ACS medicinal chemistry letters (10.02.2022)
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Journal Article
Biochemical Characterization of Recombinant Hepatitis C Virus Nonstructural Protein 4B: Evidence for ATP/GTP Hydrolysis and Adenylate Kinase Activity
Thompson, Aaron A, Zou, Aihua, Yan, Jiangli, Duggal, Rohit, Hao, Weidong, Molina, David, Cronin, Ciarán N, Wells, Peter A
Published in Biochemistry (Easton) (10.02.2009)
Published in Biochemistry (Easton) (10.02.2009)
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Journal Article
Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system
Caspers, Nicole L., Han, Seungil, Rajamohan, Francis, Hoth, Lise R., Geoghegan, Kieran F., Subashi, Timothy A., Vazquez, Michael L., Kaila, Neelu, Cronin, Ciarán N., Johnson, Eric, Kurumbail, Ravi G.
Published in Acta crystallographica. Section F, Structural biology communications (01.11.2016)
Published in Acta crystallographica. Section F, Structural biology communications (01.11.2016)
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Journal Article
Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation
Mol, Clifford D., Lim, Kheng B., Sridhar, Vandana, Zou, Hua, Chien, Ellen Y.T., Sang, Bi-Ching, Nowakowski, Jacek, Kassel, Daniel B., Cronin, Ciarán N., McRee, Duncan E.
Published in The Journal of biological chemistry (22.08.2003)
Published in The Journal of biological chemistry (22.08.2003)
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Journal Article
Structures of the Cancer-Related Aurora-A, FAK, and EphA2 Protein Kinases from Nanovolume Crystallography
Nowakowski, Jacek, Cronin, Ciarán N., McRee, Duncan E., Knuth, Mark W., Nelson, Christian G., Pavletich, Nikola P., Rogers, Joe, Sang, Bi-Ching, Scheibe, Daniel N., Swanson, Ronald V., Thompson, Devon A.
Published in Structure (London) (01.12.2002)
Published in Structure (London) (01.12.2002)
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Economical parallel protein expression screening and scale-up in Escherichia coli
Brodsky, Oleg, Cronin, Ciarán N
Published in Journal of structural and functional genomics (01.06.2006)
Published in Journal of structural and functional genomics (01.06.2006)
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