Search Results - "CROGHAN, MICHAEL" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σS–X) Interaction for Conformational Constraint

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σS–X) Interaction for Conformational Constraint

by Pennington, Lewis D, Bartberger, Michael D, Croghan, Michael D, Andrews, Kristin L, Ashton, Kate S, Bourbeau, Matthew P, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W, Jordan, Steven R, Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H, Reichelt, Andreas, Siegmund, Aaron C, Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M, Van, Gwyneth, Yang, Kevin C, Yao, Guomin, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J
Published in Journal of medicinal chemistry (24.12.2015)

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Journal Article

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

by Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge
Published in Journal of medicinal chemistry (08.11.2012)

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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

by Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge
Published in Journal of medicinal chemistry (08.11.2012)

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

by Ashton, Kate S., Andrews, Kristin L., Bryan, Marion C., Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R., Kurzeja, Robert J. M., Michelsen, Klaus, Pennington, Lewis D., Poon, Steve F., Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L., Wahl, Robert C., Zhang, Jiandong, Lloyd, David J., Hale, Clarence, St. Jean, David J.
Published in Journal of medicinal chemistry (23.01.2014)

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Journal Article

Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon

Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon

by Harried, Scott S, Croghan, Michael D, Kaller, Matthew R, Lopez, Patricia, Zhong, Wenge, Hungate, Randall, Reider, Paul J
Published in Journal of organic chemistry (21.08.2009)

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Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity

Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity

by Pennington, Lewis D., Croghan, Michael D., Sham, Kelvin K.C., Pickrell, Alexander J., Harrington, Paul E., Frohn, Michael J., Lanman, Brian A., Reed, Anthony B., Lee, Matthew R., Xu, Han, McElvain, Michele, Xu, Yang, Zhang, Xuxia, Fiorino, Michael, Horner, Michelle, Morrison, Henry G., Arnett, Heather A., Fotsch, Christopher, Tasker, Andrew S., Wong, Min, Cee, Victor J.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

by Kaller, Matthew R, Harried, Scott S, Albrecht, Brian, Amarante, Patricia, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Brown, Ryan, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Graceffa, Russell, Hickman, Dean, Judd, Ted, Kriemen, Chuck, La, Daniel, Li, Vivian, Lopez, Patricia, Luo, Yi, Masse, Craig, Monenschein, Holger, Nguyen, Thomas, Pennington, Lewis D, Miguel, Tisha San, Sickmier, E. Allen, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, Williamson, Toni, Wood, Stephen, Xue, May, Yang, Bryant, Zhang, Jianhua, Patel, Vinod, Zhong, Wenge, Hitchcock, Stephen
Published in ACS medicinal chemistry letters (08.11.2012)

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Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core

Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core

by Harrington, Paul E, Croghan, Michael D, Fotsch, Christopher, Frohn, Mike, Lanman, Brian A, Pennington, Lewis D, Pickrell, Alexander J, Reed, Anthony B, Sham, Kelvin K. C, Tasker, Andrew, Arnett, Heather A, Fiorino, Michael, Lee, Matthew R, McElvain, Michele, Morrison, Henry G, Xu, Han, Xu, Yang, Zhang, Xuxia, Wong, Min, Cee, Victor J
Published in ACS medicinal chemistry letters (12.01.2012)

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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH2

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH2

by FOTSCH, Christopher, SMITH, Duncan M, TAMAYO, Nuria A, NING XI, BAUMGARTNER, James W, ADAMS, Jeffrey A, CHEETHAM, Janet, CROGHAN, Michael, DOHERTY, Elizabeth M, HALE, Clarence, JAROSINSKI, Mark A, KELLY, Michael G, NORMAN, Mark H
Published in Bioorganic & medicinal chemistry letters (21.07.2003)

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4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1

4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1

by Pennington, Lewis D, Sham, Kelvin K. C, Pickrell, Alexander J, Harrington, Paul E, Frohn, Michael J, Lanman, Brian A, Reed, Anthony B, Croghan, Michael D, Lee, Matthew R, Xu, Han, McElvain, Michele, Xu, Yang, Zhang, Xuxia, Fiorino, Michael, Horner, Michelle, Morrison, Henry G, Arnett, Heather A, Fotsch, Christopher, Wong, Min, Cee, Victor J
Published in ACS medicinal chemistry letters (13.10.2011)

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Correction to Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

Correction to Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

by Ashton, Kate S, Andrews, Kristin L, Bryan, Marian C, Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R, Kurzeja, Robert J. M, Michelsen, Klaus, Pennington, Lewis D, Poon, Steve F, Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L, Wahl, Robert C, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J
Published in Journal of medicinal chemistry (27.03.2014)

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Journal Article

4-Methoxy- N -[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P 1

4-Methoxy- N -[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P 1

by Pennington, Lewis D., Sham, Kelvin K. C., Pickrell, Alexander J., Harrington, Paul E., Frohn, Michael J., Lanman, Brian A., Reed, Anthony B., Croghan, Michael D., Lee, Matthew R., Xu, Han, McElvain, Michele, Xu, Yang, Zhang, Xuxia, Fiorino, Michael, Horner, Michelle, Morrison, Henry G., Arnett, Heather A., Fotsch, Christopher, Wong, Min, Cee, Victor J.
Published in ACS medicinal chemistry letters (13.10.2011)

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Journal Article

History, Linguistic Theory, California's CLAD, and the Oakland Public Schools Resolution on Ebonics: what are the Connections?

History, Linguistic Theory, California's CLAD, and the Oakland Public Schools Resolution on Ebonics: what are the Connections?

by Croghan, Michael
Published in World Englishes (01.03.2000)

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Journal Article

The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core

The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core

by Harrington, Paul E., St. Jean, David J., Clarine, Jeffrey, Coulter, Thomas S., Croghan, Michael, Davenport, Adam, Davis, James, Ghiron, Chiara, Hutchinson, Jonathan, Kelly, Michael G., Lott, Fred, Lu, Jenny Ying-Lin, Martin, David, Morony, Sean, Poon, Steve F., Portero-Larragueta, Elena, Reagan, Jeff D., Regal, Kelly A., Tasker, Andrew, Wang, Minghan, Yang, Yuhua, Yao, Guomin, Zeng, Qingping, Henley, Charles, Fotsch, Christopher
Published in Bioorganic & medicinal chemistry letters (15.09.2010)

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Journal Article

Optimization of a Potent, Orally Active S1P 1 Agonist Containing a Quinolinone Core

Optimization of a Potent, Orally Active S1P 1 Agonist Containing a Quinolinone Core

by Harrington, Paul E., Croghan, Michael D., Fotsch, Christopher, Frohn, Mike, Lanman, Brian A., Pennington, Lewis D., Pickrell, Alexander J., Reed, Anthony B., Sham, Kelvin K. C., Tasker, Andrew, Arnett, Heather A., Fiorino, Michael, Lee, Matthew R., McElvain, Michele, Morrison, Henry G., Xu, Han, Xu, Yang, Zhang, Xuxia, Wong, Min, Cee, Victor J.
Published in ACS medicinal chemistry letters (12.01.2012)

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Journal Article

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2)

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2)

by Fotsch, Christopher, Smith, Duncan M, Adams, Jeffrey A, Cheetham, Janet, Croghan, Michael, Doherty, Elizabeth M, Hale, Clarence, Jarosinski, Mark A, Kelly, Michael G, Norman, Mark H, Tamayo, Nuria A, Xi, Ning, Baumgartner, James W
Published in Bioorganic & medicinal chemistry letters (21.07.2003)

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Journal Article

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro- dPhe-Arg-Trp-Lys]-NH 2

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro- dPhe-Arg-Trp-Lys]-NH 2

by Fotsch, Christopher, Smith, Duncan M, Adams, Jeffrey A, Cheetham, Janet, Croghan, Michael, Doherty, Elizabeth M, Hale, Clarence, Jarosinski, Mark A, Kelly, Michael G, Norman, Mark H, Tamayo, Nuria A, Xi, Ning, Baumgartner, James W
Published in Bioorganic & medicinal chemistry letters (2003)

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Journal Article

Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use

Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use

by CROGHAN MICHAEL, YANG BRYANT, ZHONG WENGE, VINOD PATEL F, HITCHCOCK STEPHEN
Year of Publication 21.01.2014

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Patent

ChemInform Abstract: Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon

ChemInform Abstract: Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon

by Harried, Scott S., Croghan, Michael D., Kaller, Matthew R., Lopez, Patricia, Zhong, Wenge, Hungate, Randall, Reider, Paul J.
Published in ChemInform (12.01.2010)

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Journal Article

BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES

BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES

by FOTSCH CHRISTOPHER H, TEGLEY CHRISTOPHER M, REICHELT ANDREAS, BARTBERGER MICHAEL DAVID, NORMAN MARK H, ST. JEAN, JR. DAVID J, CROGHAN MICHAEL D, PENNINGTON LEWIS DALE
Year of Publication 05.06.2014

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Patent

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