Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection
Summa, Vincenzo, Petrocchi, Alessia, Bonelli, Fabio, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Fiore, Fabrizio, Gardelli, Cristina, Gonzalez Paz, Odalys, Hazuda, Daria J, Jones, Philip, Kinzel, Olaf, Laufer, Ralph, Monteagudo, Edith, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Scarpelli, Rita, Stillmock, Kara, Witmer, Marc V, Rowley, Michael
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D
Lafontaine, Jennifer A, Provencal, David P, Gardelli, Cristina, Leahy, James W
Published in Journal of organic chemistry (30.05.2003)
Published in Journal of organic chemistry (30.05.2003)
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Synthesis of a hexahydropyrimido[1,2- a]azepine-2-carboxamide derivative useful as an HIV integrase inhibitor
Ferrara, Marco, Crescenzi, Benedetta, Donghi, Monica, Muraglia, Ester, Nizi, Emanuela, Pesci, Silvia, Summa, Vincenzo, Gardelli, Cristina
Published in Tetrahedron letters (19.11.2007)
Published in Tetrahedron letters (19.11.2007)
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The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease
Ontoria, Jesus M, Di Marco, Stefania, Conte, Immacolata, Di Francesco, M. Emilia, Gardelli, Cristina, Koch, Uwe, Matassa, Victor G, Poma, Marco, Steinkühler, Christian, Volpari, Cinzia, Harper, Steven
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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Regiochemical control of the ring opening of 1,2-epoxides by means of chelating processes. 8. Synthesis and ring opening reactions of cis- and trans- oxides derived from 3-benzyloxycyclohexene and 2-benzyloxy-5,6-dihydro-2H-pyran
Calvani, Federico, Crotti, Paolo, Gardelli, Cristina, Pineschi, Mauro
Published in Tetrahedron (01.01.1994)
Published in Tetrahedron (01.01.1994)
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Regiochemical control of the ring opening of 1,2-epoxides by means of chelating processes. 5. Synthesis and reactions of some 2,3-epoxy-1-alkanol derivatives
Chini, Marco, Crotti, Paolo, Flippin, Lee A, Gardelli, Cristina, Giovani, Elena, Macchia, Franco, Pineschi, Mauro
Published in Journal of organic chemistry (01.02.1993)
Published in Journal of organic chemistry (01.02.1993)
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Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists
Cooper, Martin, Llinas, Antonio, Hansen, Peter, Caffrey, Moya, Ray, Asim, Sjödin, Stina, Shamovsky, Igor, Wada, Hiroki, Jellesmark Jensen, Tina, Sivars, Ulf, Hultin, Leif, Andersson, Ulf, Lundqvist, Sara, Gedda, Karin, Jinton, Lisa, Krutrök, Nina, Lewis, Richard, Jansson, Paul, Gardelli, Cristina
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors
Pemberton, Nils, Mogemark, Mickael, Arlbrandt, Susanne, Bold, Peter, Cox, Rhona J, Gardelli, Cristina, Holden, Neil S, Karabelas, Kostas, Karlsson, Johan, Lever, Sarah, Li, Xueshan, Lindmark, Helena, Norberg, Monica, Perry, Matthew W. D, Petersen, Jens, Rodrigo Blomqvist, Sandra, Thomas, Matthew, Tyrchan, Christian, Westin Eriksson, Annika, Zlatoidsky, Pavol, Öster, Linda
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Abstract 100: Novel selective PI3Kγ inhibitor AZD3458 promotes anti-tumor immune responses and reverts resistance to immunotherapy in checkpoint blockade refractory preclinical models
Carnevalli, Larissa S., Carrol, Danielle, Moschetta, Michele, Gutierrez, Pablo Morentin, Gardelli, Cristina, Taylor, Molly A., Montoya, Antonio, Hughes, Adina, King, Matthew, Klinowska, Teresa, Barry, Simon T.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition
Carnevalli, Larissa S, Taylor, Molly A, King, Matthew, Coenen-Stass, Anna M L, Hughes, Adina M, Bell, Sigourney, Proia, Theresa A, Wang, Yanjun, Ramos-Montoya, Antonio, Wali, Neha, Carroll, Danielle, Singh, Maneesh, Moschetta, Michele, Gutierrez, Pablo Morentin, Gardelli, Cristina, Critchlow, Susan E, Klinowska, Teresa, Fawell, Stephen E, Barry, Simon T
Published in Molecular cancer therapeutics (01.06.2021)
Published in Molecular cancer therapeutics (01.06.2021)
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Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists
Gardelli, Cristina, Wada, Hiroki, Ray, Asim, Caffrey, Moya, Llinas, Antonio, Shamovsky, Igor, Tholander, Joakim, Larsson, Joakim, Sivars, Ulf, Hultin, Leif, Andersson, Ulf, Sanganee, Hitesh J, Stenvall, Kristina, Leidvik, Brith, Gedda, Karin, Jinton, Lisa, Rydén Landergren, Marie, Karabelas, Kostas
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Regiochemical control of the ring opening of 1,2-epoxides by means of chelating processes. 4. Synthesis and reactions of the cis- and trans-oxides derived from 3-[(benzyloxy)methyl]cyclohexene
Chini, Marco, Crotti, Paolo, Flippin, Lee A, Gardelli, Cristina, Macchia, Franco
Published in Journal of organic chemistry (01.03.1992)
Published in Journal of organic chemistry (01.03.1992)
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Journal Article
4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species
Summa, Vincenzo, Petrocchi, Alessia, Matassa, Victor G, Gardelli, Cristina, Muraglia, Ester, Rowley, Michael, Paz, Odalys Gonzalez, Laufer, Ralph, Monteagudo, Edith, Pace, Paola
Published in Journal of medicinal chemistry (16.11.2006)
Published in Journal of medicinal chemistry (16.11.2006)
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Regiochemical Control of the Ring Opening of Aziridines by Means of Chelating Processes. Synthesis and Ring-Opening Reactions of cis- and trans-Aziridines Derived from 4-(Benzyloxy)cyclohexene
Crotti, Paolo, Favero, Lucilla, Gardelli, Cristina, Macchia, Franco, Pineschi, Mauro
Published in Journal of organic chemistry (01.04.1995)
Published in Journal of organic chemistry (01.04.1995)
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Phosphoramidate Prodrugs of 2′-C-Methylcytidine for Therapy of Hepatitis C Virus Infection
Gardelli, Cristina, Attenni, Barbara, Donghi, Monica, Meppen, Malte, Pacini, Barbara, Harper, Steven, Di Marco, Annalise, Fiore, Fabrizio, Giuliano, Claudio, Pucci, Vincenzo, Laufer, Ralph, Gennari, Nadia, Marcucci, Isabella, Leone, Joseph F, Olsen, David B, MacCoss, Malcolm, Rowley, Michael, Narjes, Frank
Published in Journal of medicinal chemistry (10.09.2009)
Published in Journal of medicinal chemistry (10.09.2009)
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Discovery and Synthesis of HIV Integrase Inhibitors: Development of Potent and Orally Bioavailable N-Methyl Pyrimidones
Gardelli, Cristina, Nizi, Emanuela, Muraglia, Ester, Crescenzi, Benedetta, Ferrara, Marco, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Poma, Marco, Rico Ferreira, Maria del Rosario, Scarpelli, Rita, Homnick, Carl F, Ikemoto, Norihiro, Alfieri, Anna, Verdirame, Maria, Bonelli, Fabio, Gonzalez Paz, Odalys, Taliani, Marina, Monteagudo, Edith, Pesci, Silvia, Laufer, Ralph, Felock, Peter, Stillmock, Kara A, Hazuda, Daria, Rowley, Michael, Summa, Vincenzo
Published in Journal of medicinal chemistry (04.10.2007)
Published in Journal of medicinal chemistry (04.10.2007)
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Journal Article
Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors
Pace, Paola, Di Francesco, M. Emilia, Gardelli, Cristina, Harper, Steven, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Petrocchi, Alessia, Poma, Marco, Rowley, Michael, Scarpelli, Rita, Laufer, Ralph, Gonzalez Paz, Odalys, Monteagudo, Edith, Bonelli, Fabio, Hazuda, Daria, Stillmock, Kara A, Summa, Vincenzo
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Journal Article
Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors
Muraglia, Ester, Kinzel, Olaf, Gardelli, Cristina, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Nizi, Emanuela, Orvieto, Federica, Pescatore, Giovanna, Laufer, Ralph, Gonzalez-Paz, Odalys, Di Marco, Annalise, Fiore, Fabrizio, Monteagudo, Edith, Fonsi, Massimiliano, Felock, Peter J, Rowley, Michael, Summa, Vincenzo
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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