The serotonergic and alpha-1 adrenergic receptor modulator ACH-000029 ameliorates anxiety-like behavior in a post-traumatic stress disorder model
Azevedo, Hatylas, Ferreira, Marcos, Mascarello, Alessandra, Osten, Pavel, Werneck Guimarães, Cristiano Ruch
Published in Neuropharmacology (01.03.2020)
Published in Neuropharmacology (01.03.2020)
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Journal Article
Synthetic and Theoretical Studies on the Reduction of Electron Withdrawing Group Conjugated Olefins Using the Hantzsch 1,4-Dihydropyridine Ester
Garden, Simon J, Guimarães, Cristiano Ruch Werneck, Corréa, Marilza B, Oliveira, César Augusto Fernandes de, Pinto, Angelo da Cunha, Bicca de Alencastro, Ricardo
Published in Journal of organic chemistry (14.11.2003)
Published in Journal of organic chemistry (14.11.2003)
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Journal Article
Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition
Mascarello, Alessandra, Azevedo, Hatylas, Ferreira Junior, Marcos Antonio, Ishikawa, Eloisa Eriko, Guimarães, Cristiano Ruch Werneck
Published in European journal of pharmaceutical sciences (01.04.2021)
Published in European journal of pharmaceutical sciences (01.04.2021)
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Journal Article
Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats
Ferreira, Marcos Antonio, Azevedo, Hatylas, Mascarello, Alessandra, Segretti, Natanael Dante, Russo, Elisa, Russo, Valter, Guimarães, Cristiano Ruch Werneck
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
Investigation of Solvent Effects for the Claisen Rearrangement of Chorismate to Prephenate: Mechanistic Interpretation via Near Attack Conformations
Repasky, Matthew P, Guimarães, Cristiano Ruch Werneck, Chandrasekhar, Jayaraman, Tirado-Rives, Julian, Jorgensen, William L
Published in Journal of the American Chemical Society (04.06.2003)
Published in Journal of the American Chemical Society (04.06.2003)
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Journal Article
Brain-wide mapping of c-fos expression in the single prolonged stress model and the effects of pretreatment with ACH-000029 or prazosin
Azevedo, Hatylas, Ferreira, Marcos, Mascarello, Alessandra, Osten, Pavel, Guimarães, Cristiano Ruch Werneck
Published in Neurobiology of stress (01.11.2020)
Published in Neurobiology of stress (01.11.2020)
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Journal Article
Contributions of Conformational Compression and Preferential Transition State Stabilization to the Rate Enhancement by Chorismate Mutase
Guimarães, Cristiano Ruch Werneck, Repasky, Matthew P, Chandrasekhar, Jayaraman, Tirado-Rives, Julian, Jorgensen, William L
Published in Journal of the American Chemical Society (11.06.2003)
Published in Journal of the American Chemical Society (11.06.2003)
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Journal Article
A molecular dynamics study of an L-type calcium channel model
Barreiro, Gabriela, Guimarães, Cristiano Ruch Werneck, de Alencastro, Ricardo Bicca
Published in Protein engineering (01.02.2002)
Published in Protein engineering (01.02.2002)
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Journal Article
Preclinical characterization of ACH-000029, a novel anxiolytic compound acting on serotonergic and alpha-adrenergic receptors
Azevedo, Hatylas, Ferreira, Marcos, Costa, Renata Watanabe, Russo, Valter, Russo, Elisa, Mascarello, Alessandra, Guimarães, Cristiano Ruch Werneck
Published in Progress in neuro-psychopharmacology & biological psychiatry (20.12.2019)
Published in Progress in neuro-psychopharmacology & biological psychiatry (20.12.2019)
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Journal Article
Potential of mean force calculations on an L-type calcium channel model
Barreiro, Gabriela, Guimarães, Cristiano Ruch Werneck, de Alencastro, Ricardo Bicca
Published in Protein engineering (01.03.2003)
Published in Protein engineering (01.03.2003)
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Journal Article
Investigation of the induced-fit mechanism and catalytic activity of the human cytomegalovirus protease homodimer via molecular dynamics simulations
de Oliveira, César Augusto Fernandes, Guimarães, Cristiano Ruch Werneck, Barreiro, Gabriela, de Alencastro, Ricardo Bicca
Published in Proteins, structure, function, and bioinformatics (01.09.2003)
Published in Proteins, structure, function, and bioinformatics (01.09.2003)
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Journal Article
A molecular dynamics study on liquid 1‐octanol. Part 3. Evaluating octanol/water partition coefficients of novel thrombin inhibitors via free‐energy perturbations
Fernandes De Oliveira, César Augusto, Werneck Guimarães, Cristiano Ruch, De Mello, Heloisa, Echevarria, Aurea, De Alencastro, Ricardo Bicca
Published in International journal of quantum chemistry (20.04.2005)
Published in International journal of quantum chemistry (20.04.2005)
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Journal Article
Gut microbiota genus network reflects Alzheimer’s disease clinical stages
Lima, Amanda Muliterno Domingues Lourenço, Rosa, Morghana Machado, Machado, Luiza Santos, Salgaço, Mateus Kawata, Cassia Pessotti, Rita, Saverio, Stephani, Guimarães, Cristiano Ruch Werneck, de Freitas, Miller Nunes, Sivieri, Katia, Bastiani, Marco Antônio De, Zimmer, Eduardo R.
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
Human Cytomegalovirus Protease: Why is the Dimer Required for Catalytic Activity?
de Oliveira, César Augusto Fernandes, Guimarães, Cristiano Ruch Werneck, Barreiro, Gabriela, de Alencastro, Ricardo Bicca
Published in Journal of chemical theory and computation (01.01.2007)
Published in Journal of chemical theory and computation (01.01.2007)
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Journal Article