Search Results - "CRAMER, Merryl" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

by Zarrinkar, Patrick P., Gunawardane, Ruwanthi N., Cramer, Merryl D., Gardner, Michael F., Brigham, Daniel, Belli, Barbara, Karaman, Mazen W., Pratz, Keith W., Pallares, Gabriel, Chao, Qi, Sprankle, Kelly G., Patel, Hitesh K., Levis, Mark, Armstrong, Robert C., James, Joyce, Bhagwat, Shripad S.
Published in Blood (01.10.2009)

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Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

by Chao, Qi, Sprankle, Kelly G, Grotzfeld, Robert M, Lai, Andiliy G, Carter, Todd A, Velasco, Anne Marie, Gunawardane, Ruwanthi N, Cramer, Merryl D, Gardner, Michael F, James, Joyce, Zarrinkar, Patrick P, Patel, Hitesh K, Bhagwat, Shripad S
Published in Journal of medicinal chemistry (10.12.2009)

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Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

by Rowbottom, Martin W, Faraoni, Raffaella, Chao, Qi, Campbell, Brian T, Lai, Andiliy G, Setti, Eduardo, Ezawa, Maiko, Sprankle, Kelly G, Abraham, Sunny, Tran, Lan, Struss, Brian, Gibney, Michael, Armstrong, Robert C, Gunawardane, Ruwanthi N, Nepomuceno, Ronald R, Valenta, Ianina, Hua, Helen, Gardner, Michael F, Cramer, Merryl D, Gitnick, Dana, Insko, Darren E, Apuy, Julius L, Jones-Bolin, Susan, Ghose, Arup K, Herbertz, Torsten, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce, Williams, Michael, Bhagwat, Shripad, James, Joyce, Holladay, Mark W
Published in Journal of medicinal chemistry (09.02.2012)

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CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity

CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity

by James, Joyce, Ruggeri, Bruce, Armstrong, Robert C, Rowbottom, Martin W, Jones-Bolin, Susan, Gunawardane, Ruwanthi N, Dobrzanski, Pawel, Gardner, Michael F, Zhao, Hugh, Cramer, Merryl D, Hunter, Kathryn, Nepomuceno, Ronald R, Cheng, Mangeng, Gitnick, Dana, Yazdanian, Mehran, Insko, Darren E, Ator, Mark A, Apuy, Julius L, Faraoni, Raffaella, Dorsey, Bruce D, Williams, Michael, Bhagwat, Shripad S, Holladay, Mark W
Published in Molecular cancer therapeutics (01.04.2012)

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Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

by Abraham, Sunny, Hadd, Michael J., Tran, Lan, Vickers, Troy, Sindac, Janice, Milanov, Zdravko V., Holladay, Mark W., Bhagwat, Shripad S., Hua, Helen, Ford Pulido, Julia M., Cramer, Merryl D., Gitnick, Dana, James, Joyce, Dao, Alan, Belli, Barbara, Armstrong, Robert C., Treiber, Daniel K., Liu, Gang
Published in Bioorganic & medicinal chemistry letters (15.09.2011)

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4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors

by Holladay, Mark W., Campbell, Brian T., Rowbottom, Martin W., Chao, Qi, Sprankle, Kelly G., Lai, Andiliy G., Abraham, Sunny, Setti, Eduardo, Faraoni, Raffaella, Tran, Lan, Armstrong, Robert C., Gunawardane, Ruwanthi N., Gardner, Michael F., Cramer, Merryl D., Gitnick, Dana, Ator, Mark A., Dorsey, Bruce D., Ruggeri, Bruce R., Williams, Michael, Bhagwat, Shripad S., James, Joyce
Published in Bioorganic & medicinal chemistry letters (15.09.2011)

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METABOLISM AND DISPOSITION OF A POTENT GROUP II METABOTROPIC GLUTAMATE RECEPTOR AGONIST, IN RATS, DOGS, AND MONKEYS

METABOLISM AND DISPOSITION OF A POTENT GROUP II METABOTROPIC GLUTAMATE RECEPTOR AGONIST, IN RATS, DOGS, AND MONKEYS

by JAMES, Joyce K, NAKAMURA, Masato, NAKAZATO, Atsuro, ZHANG, Kanyin E, CRAMER, Merryl, BRUNNER, Janice, COOK, Jacquelynn, CHEN, Weichao G
Published in Drug metabolism and disposition (01.09.2005)

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CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity

CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity

by James, Joyce, Ruggeri, Bruce, Armstrong, Robert C., Rowbottom, Martin W., Jones-Bolin, Susan, Gunawardane, Ruwanthi N., Dobrzanski, Pawel, Gardner, Michael F., Zhao, Hugh, Cramer, Merryl D., Hunter, Kathryn, Nepomuceno, Ronald R., Cheng, Mangeng, Gitnick, Dana, Yazdanian, Mehran, Insko, Darren E., Ator, Mark A., Apuy, Julius L., Faraoni, Raffaella, Dorsey, Bruce D., Williams, Michael, Bhagwat, Shripad S., Holladay, Mark W.
Published in Molecular cancer therapeutics (01.04.2012)

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Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

by Bonnefous, Céline, Vernier, Jean-Michel, Hutchinson, John H., Gardner, Michael F., Cramer, Merryl, James, Joyce K., Rowe, Blake A., Daggett, Lorrie P., Schaffhauser, Hervé, Kamenecka, Theodore M.
Published in Bioorganic & medicinal chemistry letters (01.10.2005)

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4-Quinazolinyloxy-diaryl ureas as novel BRAF super(V600E inhibitors)

4-Quinazolinyloxy-diaryl ureas as novel BRAF super(V600E inhibitors)

by Holladay, Mark W, Campbell, Brian T, Rowbottom, Martin W, Chao, Qi, Sprankle, Kelly G, Lai, Andiliy G, Abraham, Sunny, Setti, Eduardo, Faraoni, Raffaella, Tran, Lan, Armstrong, Robert C, Gunawardane, Ruwanthi N, Gardner, Michael F, Cramer, Merryl D, Gitnick, Dana, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce R, Williams, Michael, Bhagwat, Shripad S, James, Joyce
Published in Bioorganic & medicinal chemistry letters (15.09.2011)

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In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP)

In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP)

by GREEN, Mitchell D, XIAOQING YANG, CRAMER, Merryl, KING, Christopher D
Published in Neuroscience letters (2005)

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5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity

by Roppe, Jeffrey R, Wang, Bowei, Huang, Dehua, Tehrani, Lida, Kamenecka, Theodore, Schweiger, Edwin J, Anderson, Jeffery J, Brodkin, Jesse, Jiang, Xiaohui, Cramer, Merryl, Chung, Janice, Reyes-Manalo, Grace, Munoz, Benito, Cosford, Nicholas D.P
Published in Bioorganic & medicinal chemistry letters (02.08.2004)

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3-[3-Fluoro-5-(5-pyridin-2-yl-2 H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

3-[3-Fluoro-5-(5-pyridin-2-yl-2 H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

by Poon, Steve F., Eastman, Brian W., Chapman, Deborah F., Chung, Janice, Cramer, Merryl, Holtz, Gregory, Cosford, Nicholas D.P., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)

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2-{2-[3-(Pyridin-3-yloxy)phenyl]-2 H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2 H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

by Huang, Dehua, Poon, Steve F., Chapman, Deborah F., Chung, Janice, Cramer, Merryl, Reger, Thomas S., Roppe, Jeffrey R., Tehrani, Lida, Cosford, Nicholas D.P., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)

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In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP)

In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP)

by Green, Mitchell D., Yang, Xiaoqing, Cramer, Merryl, King, Christopher D.
Published in Neuroscience letters (02.01.2006)

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the α2δ subunit of voltage gated calcium channels

Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the α2δ subunit of voltage gated calcium channels

by STEARNS, Brian A, ANKER, Naomi, SABLAD, Marciano, SANTINI, Angelina, SCHAFFHAUSER, Herve, URBAN, Mark O, MUNOZ, Benito, ARRUDA, Jeannie M, CAMPBELL, Brian T, CHIXU CHEN, CRAMER, Merryl, TAO HU, XIAOHUI JIANG, PARK, Kenneth, KUN KUN REN
Published in Bioorganic & medicinal chemistry letters (08.03.2004)

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3-[Substituted]-5-(5-pyridin-2-yl-2 H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

3-[Substituted]-5-(5-pyridin-2-yl-2 H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

by Tehrani, Lida R., Smith, Nicholas D., Huang, Dehua, Poon, Steve F., Roppe, Jeffrey R., Seiders, Thomas Jon, Chapman, Deborah F., Chung, Janice, Cramer, Merryl, Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.11.2005)

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Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

by Smith, Nicholas D., Poon, Steve F., Huang, Dehua, Green, Mitchell, King, Christopher, Tehrani, Lida, Roppe, Jeffrey R., Chung, Janice, Chapman, Deborah P., Cramer, Merryl, Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)

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Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia

Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia

by Smith, Nicholas D., Reger, Thomas S., Payne, Joseph, Zunic, Jasmine, Lorrain, Dan, Correa, Lucie, Stock, Nicholas, Cramer, Merryl, Chen, Weichao, Yang, Jennifer, Prasit, Peppi, Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (01.07.2005)

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Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists

Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists

by Chua, Peter C., Nagasawa, Johnny Y., Bleicher, Leo S., Munoz, Benito, Schweiger, Edwin J., Tehrani, Lida, Anderson, Jeffrey J., Cramer, Merryl, Chung, Janice, Green, Mitchell D., King, Chris D., Reyes-Manalo, Grace, Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.10.2005)

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