Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma
Sakemura, Reona, Hefazi, Mehrdad, Siegler, Elizabeth L., Cox, Michelle J., Larson, Daniel P., Hansen, Michael J., Roman, Claudia Manriquez, Schick, Kendall J, Can, Ismail, Tapper, Erin E., Horvei, Paulina, Adada, Mohamad M., Bezerra, Evandro D., Fonkoua, Lionel Aurelien Kankeu, Ruff, Michael W., Nevala, Wendy K., Walters, Denise K., Parikh, Sameer A., Lin, Yi, Jelinek, Diane F., Kay, Neil E., Bergsagel, P. Leif, Kenderian, Saad S.
Published in Blood (30.06.2022)
Published in Blood (30.06.2022)
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Journal Article
IL-4 drives exhaustion of CD8+ CART cells
Stewart, Carli M., Siegler, Elizabeth L., Sakemura, R. Leo, Cox, Michelle J., Huynh, Truc, Kimball, Brooke, Mai, Long, Can, Ismail, Manriquez Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Ogbodo, Ekene, Mohammed Ismail, Wazim, Gaspar-Maia, Alexandre, Budka, Justin, Kim, Jenny, Scholler, Nathalie, Mattie, Mike, Filosto, Simone, Kenderian, Saad S.
Published in Nature communications (12.09.2024)
Published in Nature communications (12.09.2024)
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Journal Article
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
Sterner, Rosalie M., Sakemura, Reona, Cox, Michelle J., Yang, Nan, Khadka, Roman H., Forsman, Cynthia L., Hansen, Michael J., Jin, Fang, Ayasoufi, Katayoun, Hefazi, Mehrdad, Schick, Kendall J., Walters, Denise K., Ahmed, Omar, Chappell, Dale, Sahmoud, Tarek, Durrant, Cameron, Nevala, Wendy K., Patnaik, Mrinal M., Pease, Larry R., Hedin, Karen E., Kay, Neil E., Johnson, Aaron J., Kenderian, Saad S.
Published in Blood (14.02.2019)
Published in Blood (14.02.2019)
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Journal Article
Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells
Sterner, Rosalie M, Cox, Michelle J, Sakemura, Reona, Kenderian, Saad S
Published in Journal of visualized experiments (22.07.2019)
Published in Journal of visualized experiments (22.07.2019)
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Journal Article
Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia
Cox, Michelle J., Lucien, Fabrice, Sakemura, Reona, Boysen, Justin C., Kim, Yohan, Horvei, Paulina, Manriquez Roman, Claudia, Hansen, Michael J., Tapper, Erin E., Siegler, Elizabeth L., Forsman, Cynthia, Crotts, Sydney B., Schick, Kendall J., Hefazi, Mehrdad, Ruff, Michael W., Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Kankeu Fonkoua, Lionel Aurelien, Nevala, Wendy K., Braggio, Esteban, Ding, Wei, Parikh, Sameer A., Kay, Neil E., Kenderian, Saad S.
Published in Molecular therapy (07.04.2021)
Published in Molecular therapy (07.04.2021)
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Journal Article
GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
Cox, Michelle J, Manriquez Roman, Claudia, Tapper, Erin E, Siegler, Elizabeth L, Chappell, Dale, Durrant, Cameron, Ahmed, Omar, Sinha, Sutapa, Mwangi, Raphael, Scott, Nancy S, Hefazi, Mehrdad, Schick, Kendall J, Horvei, Paulina, Ruff, Michael W, Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Kankeu Fonkoua, Lionel Aurelien, Parikh, Sameer A, Kay, Neil E, Sakemura, Reona, Kenderian, Saad S
Published in Leukemia (01.06.2022)
Published in Leukemia (01.06.2022)
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Journal Article
Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity
Sakemura, Reona, Bansal, Aditya, Siegler, Elizabeth L, Hefazi, Mehrdad, Yang, Nan, Khadka, Roman H, Newsom, Alysha N, Hansen, Michael J, Cox, Michelle J, Manriquez Roman, Claudia, Schick, Kendall J, Can, Ismail, Tapper, Erin E, Nevala, Wendy K, Adada, Mohamad M, Bezerra, Evandro D, Kankeu Fonkoua, Lionel Aurelien, Horvei, Paulina, Ruff, Michael W, Parikh, Sameer A, Pandey, Mukesh K, DeGrado, Timothy R, Suksanpaisan, Lukkana, Kay, Neil E, Peng, Kah-Whye, Russell, Stephen J, Kenderian, Saad S
Published in Cancer immunology research (01.09.2021)
Published in Cancer immunology research (01.09.2021)
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Journal Article
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Sakemura, Reona, Cox, Michelle J, Bansal, Aditya, Roman, Claudia Manriquez, Hefazi, Mehrdad, Vernon, Cynthia J, Glynn, Dianna L, Pandey, Mukesh K, DeGrado, Timothy R, Siegler, Elizabeth L, Kenderian, Saad S
Published in Journal of visualized experiments (17.02.2022)
Published in Journal of visualized experiments (17.02.2022)
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Journal Article
AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells
Sakemura, R Leo, Hefazi, Mehrdad, Cox, Michelle J, Siegler, Elizabeth L, Sinha, Sutapa, Hansen, Michael J, Stewart, Carli M, Feigin, Jennifer M, Manriquez Roman, Claudia, Schick, Kendall J, Can, Ismail, Tapper, Erin E, Horvei, Paulina, Adada, Mohamad M, Bezerra, Evandro D, Kankeu Fonkoua, Lionel Aurelien, Ruff, Michael W, Forsman, Cynthia L, Nevala, Wendy K, Boysen, Justin C, Tschumper, Renee C, Grand, Cory L, Kuchimanchi, Kameswara R, Mouritsen, Lars, Foulks, Jason M, Warner, Steven L, Call, Timothy G, Parikh, Sameer A, Ding, Wei, Kay, Neil E, Kenderian, Saad S
Published in Cancer immunology research (01.09.2023)
Published in Cancer immunology research (01.09.2023)
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Journal Article
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression
Sirpilla, Olivia, Sakemura, R Leo, Hefazi, Mehrdad, Huynh, Truc N, Can, Ismail, Girsch, James H, Tapper, Erin E, Cox, Michelle J, Schick, Kendall J, Manriquez-Roman, Claudia, Yun, Kun, Stewart, Carli M, Ogbodo, Ekene J, Kimball, Brooke L, Mai, Long K, Gutierrez-Ruiz, Omar L, Rodriguez, Makena L, Gluscevic, Martina, Larson, Daniel P, Abel, Alex M, Wierson, Wesley A, Olivier, Gloria, Siegler, Elizabeth L, Kenderian, Saad S
Published in Nature biomedical engineering (01.04.2024)
Published in Nature biomedical engineering (01.04.2024)
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Journal Article
암 치료용 물질 및 방법
KENDERIAN SAAD J, COX MICHELLE J, DURRANT CAMERON, SAKEMURA REONA, STERNER ROSALIE M, CHAPPELL DALE
Year of Publication 26.08.2021
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Year of Publication 26.08.2021
Patent
Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models
Sirpilla, Olivia, Sakemura, Reona Leo, Hefazi, Mehrdad, Girsch, James H., Huynh, Truc, Cox, Michelle J., Schick, Kendall J., Manriquez-Roman, Claudia, Can, Ismail, Yun, Kun, Stewart, Carli M., Ogbodo, Ekene J., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial
Stewart, Carli M., Cox, Michelle J., Sakemura, Reona Leo, Ogbodo, Ekene J., Can, Ismail, Manriquez-Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Huynh, Truc, Siegler, Elizabeth L., Kim, Jenny J, Mattie, Mike, Scholler, Nathalie, Filosto, Simone, Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Differential Susceptibility to Senescence in CART Cells Based on Co-Stimulatory Signaling
Can, Ismail, Sakemura, Reona Leo, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Yun, Kun, Cox, Michelle J., Huynh, Truc, Girsch, James H., Ogbodo, Ekene J., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Boysen, Justin C., Siegler, Elizabeth L., Ekiz, Atakan, Kenderian, Saad S., Kay, Neil E.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Immunosuppressive Monocyte Modulation of CAR T Cell Functions and Impact on Response to CART19
Yun, Kun, Sakemura, Reona Leo, Cox, Michelle J., Huynh, Truc, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Girsch, James H., Ogbodo, Ekene J., Can, Ismail, Kimball, Brooke, Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Siegler, Elizabeth L., Mattie, Mike, Nguyen-Mau, Sao-Mai, Filosto, Simone, Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor Efficacy
Siegler, Elizabeth L., Simone, Brandon W, Sakemura, Reona, Tapper, Erin E., Horvei, Paulina, Cox, Michelle J., Hefazi, Mehrdad, Manriquez Roman, Claudia, Can, Ismail, Schick, Kendall J., Ruff, Michael W., Ekker, Stephen C, Kenderian, Saad S.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy
Sakemura, Reona Leo, Manriquez-Roman, Claudia, Horvei, Paulina, Cox, Michelle J., Huynh, Truc, Girsch, James H., Sirpilla, Olivia, Yun, Kun, Stewart, Carli M., Can, Ismail, Ogbodo, Ekene J., Adada, Mohamad M., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Ilieva-Babinsky, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A., Ding, Wei, Kay, Neil E., Nowakowski, Grzegorz S., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article