Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
Dodd, Garron T., Decherf, Stephanie, Loh, Kim, Simonds, Stephanie E., Wiede, Florian, Balland, Eglantine, Merry, Troy L., Münzberg, Heike, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Bence, Kendra K., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony
Published in Cell (15.01.2015)
Published in Cell (15.01.2015)
Get full text
Journal Article
Mechanisms of leptin action and leptin resistance
Myers, Martin G, Cowley, Michael A, Münzberg, Heike
Published in Annual review of physiology (01.01.2008)
Published in Annual review of physiology (01.01.2008)
Get more information
Journal Article
Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
Enriori, Pablo J, Sinnayah, Puspha, Simonds, Stephanie E, Garcia Rudaz, Cecilia, Cowley, Michael A
Published in The Journal of neuroscience (24.08.2011)
Published in The Journal of neuroscience (24.08.2011)
Get full text
Journal Article
Hypothalamic POMC neurons promote cannabinoid-induced feeding
Koch, Marco, Varela, Luis, Kim, Jae Geun, Kim, Jung Dae, Hernández-Nuño, Francisco, Simonds, Stephanie E., Castorena, Carlos M., Vianna, Claudia R., Elmquist, Joel K., Morozov, Yury M., Rakic, Pasko, Bechmann, Ingo, Cowley, Michael A., Szigeti-Buck, Klara, Dietrich, Marcelo O., Gao, Xiao-Bing, Diano, Sabrina, Horvath, Tamas L.
Published in Nature (London) (05.03.2015)
Published in Nature (London) (05.03.2015)
Get full text
Journal Article
Leptin Mediates the Increase in Blood Pressure Associated with Obesity
Simonds, Stephanie E., Pryor, Jack T., Ravussin, Eric, Greenway, Frank L., Dileone, Ralph, Allen, Andrew M., Bassi, Jaspreet, Elmquist, Joel K., Keogh, Julia M., Henning, Elana, Myers, Martin G., Licinio, Julio, Brown, Russell D., Enriori, Pablo J., O’Rahilly, Stephen, Sternson, Scott M., Grove, Kevin L., Spanswick, David C., Farooqi, I. Sadaf, Cowley, Michael A.
Published in Cell (04.12.2014)
Published in Cell (04.12.2014)
Get full text
Journal Article
Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity
Dodd, Garron T., Xirouchaki, Chrysovalantou E., Eramo, Matthew, Mitchell, Christina A., Andrews, Zane B., Henry, Belinda A., Cowley, Michael A., Tiganis, Tony
Published in Cell reports (Cambridge) (10.09.2019)
Published in Cell reports (Cambridge) (10.09.2019)
Get full text
Journal Article
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
Yeo, Giles S.H., Chao, Daniela Herrera Moro, Siegert, Anna-Maria, Koerperich, Zoe M., Ericson, Mark D., Simonds, Stephanie E., Larson, Courtney M., Luquet, Serge, Clarke, Iain, Sharma, Shubh, Clément, Karine, Cowley, Michael A., Haskell-Luevano, Carrie, Van Der Ploeg, Lex, Adan, Roger A.H.
Published in Molecular metabolism (Germany) (01.06.2021)
Published in Molecular metabolism (Germany) (01.06.2021)
Get full text
Journal Article
Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons
Briggs, Dana I, Enriori, Pablo J, Lemus, Moyra B, Cowley, Michael A, Andrews, Zane B
Published in Endocrinology (Philadelphia) (01.10.2010)
Published in Endocrinology (Philadelphia) (01.10.2010)
Get full text
Journal Article
A BAT-Centric Approach to the Treatment of Diabetes: Turn on the Brain
Hankir, Mohammed K., Cowley, Michael A., Fenske, Wiebke K.
Published in Cell metabolism (12.07.2016)
Published in Cell metabolism (12.07.2016)
Get full text
Journal Article
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance
Loh, Kim, Fukushima, Atsushi, Zhang, Xinmei, Galic, Sandra, Briggs, Dana, Enriori, Pablo J., Simonds, Stephanie, Wiede, Florian, Reichenbach, Alexander, Hauser, Christine, Sims, Natalie A., Bence, Kendra K., Zhang, Sheng, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony
Published in Cell metabolism (02.11.2011)
Published in Cell metabolism (02.11.2011)
Get full text
Journal Article
Estradiol Prevents Fat Accumulation and Overcomes Leptin Resistance in Female High-Fat Diet Mice
Litwak, Sara A, Wilson, Jenny L, Chen, Weiyi, Garcia-Rudaz, Cecilia, Khaksari, Mohammad, Cowley, Michael A, Enriori, Pablo J
Published in Endocrinology (Philadelphia) (01.11.2014)
Published in Endocrinology (Philadelphia) (01.11.2014)
Get full text
Journal Article
Insulin regulates POMC neuronal plasticity to control glucose metabolism
Dodd, Garron T, Michael, Natalie J, Lee-Young, Robert S, Mangiafico, Salvatore P, Pryor, Jack T, Munder, Astrid C, Simonds, Stephanie E, Brüning, Jens Claus, Zhang, Zhong-Yin, Cowley, Michael A, Andrikopoulos, Sofianos, Horvath, Tamas L, Spanswick, David, Tiganis, Tony
Published in eLife (19.09.2018)
Published in eLife (19.09.2018)
Get full text
Journal Article
Leptin Signaling in the Arcuate Nucleus Reduces Insulin’s Capacity to Suppress Hepatic Glucose Production in Obese Mice
Balland, Eglantine, Chen, Weiyi, Dodd, Garron T., Conductier, Gregory, Coppari, Roberto, Tiganis, Tony, Cowley, Michael A.
Published in Cell reports (Cambridge) (08.01.2019)
Published in Cell reports (Cambridge) (08.01.2019)
Get full text
Journal Article
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
Horvath, Tamas L., Sarman, Beatrix, García-Cáceres, Cristina, Enriori, Pablo J., Sotonyi, Peter, Shanabrough, Marya, Borok, Erzsebet, Argente, Jesus, Chowen, Julie A., Perez-Tilve, Diego, Pfluger, Paul T., Brönneke, Hella S., Levin, Barry E., Diano, Sabrina, Cowley, Michael A., Tschöp, Matthias H., Friedman, Jeffrey M.
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2010)
Get full text
Journal Article
Dietary Macronutrient Composition Directs ChREBP Isoform Expression and Glucose Metabolism in Mice
Jois, Tara, Howard, Victor, Youngs, Kristina, Cowley, Michael A, Sleeman, Mark W
Published in PloS one (19.12.2016)
Published in PloS one (19.12.2016)
Get full text
Journal Article
Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
Könner, A. Christine, Janoschek, Ruth, Plum, Leona, Jordan, Sabine D., Rother, Eva, Ma, Xiaosong, Xu, Chun, Enriori, Pablo, Hampel, Brigitte, Barsh, Gregory S., Kahn, C. Ronald, Cowley, Michael A., Ashcroft, Frances M., Brüning, Jens C.
Published in Cell metabolism (01.06.2007)
Published in Cell metabolism (01.06.2007)
Get full text
Journal Article
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
Hill, Jennifer W, Williams, Kevin W, Ye, Chianping, Luo, Ji, Balthasar, Nina, Coppari, Roberto, Cowley, Michael A, Cantley, Lewis C, Lowell, Bradford B, Elmquist, Joel K
Published in The Journal of clinical investigation (01.05.2008)
Published in The Journal of clinical investigation (01.05.2008)
Get full text
Journal Article