GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions
Brun, Sonia, Bestion, Eloïne, Raymond, Eric, Bassissi, Firas, Jilkova, Zuzana Macek, Mezouar, Soraya, Rachid, Madani, Novello, Marie, Tracz, Jennifer, Hamaï, Ahmed, Lalmanach, Gilles, Vanderlynden, Lise, Legouffe, Raphael, Stauber, Jonathan, Schubert, Thomas, Plach, Maximilian G., Courcambeck, Jérôme, Drouot, Cyrille, Jacquemot, Guillaume, Serdjebi, Cindy, Roth, Gael, Baudoin, Jean-Pierre, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe
Published in Autophagy (04.03.2022)
Published in Autophagy (04.03.2022)
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Journal Article
GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma
Brun, Sonia, Bassissi, Firas, Serdjebi, Cindy, Novello, Marie, Tracz, Jennifer, Autelitano, François, Guillemot, Marie, Fabre, Philippe, Courcambeck, Jérôme, Ansaldi, Christelle, Raymond, Eric, Halfon, Philipe
Published in Investigational new drugs (01.12.2019)
Published in Investigational new drugs (01.12.2019)
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Journal Article
GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer
Brun, Sonia, Pascussi, Jean-Marc, Gifu, Elena Patricia, Bestion, Eloïne, Macek-Jilkova, Zuzana, Wang, Guanxiong, Bassissi, Firas, Mezouar, Soraya, Courcambeck, Jérôme, Merle, Philippe, Decaens, Thomas, Pannequin, Julie, Halfon, Philippe, Caron de Fromentel, Claude
Published in Journal of Cancer (01.01.2021)
Published in Journal of Cancer (01.01.2021)
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Journal Article
Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model
Lagaye, Sylvie, Brun, Sonia, Gaston, Jesintha, Shen, Hong, Stranska, Ruzena, Camus, Claire, Dubray, Clarisse, Rousseau, Géraldine, Massault, Pierre-Philippe, Courcambeck, Jerôme, Bassisi, Firas, Halfon, Philippe, Pol, Stanislas
Published in World journal of hepatology (28.07.2016)
Published in World journal of hepatology (28.07.2016)
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Journal Article
Mutation rate in hepatitis C virus NS3 protease is not influenced by HIV-1 protease inhibitor therapy
Halfon, Philippe, Bourlière, Marc, Khiri, Hacène, Pénaranda, Guillaume, Martineau, Agnes, Oulès, Valérie, Courcambeck, Jérôme, Philibert, Patrick
Published in AIDS (London) (20.08.2008)
Published in AIDS (London) (20.08.2008)
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Journal Article
GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition
Bestion, Eloïne, Jilkova, Zuzana Macek, Mège, Jean-Louis, Novello, Marie, Kurma, Keerthi, Pour, Seyedeh Tayebeh Ahmad, Lalmanach, Gilles, Vanderlynden, Lise, Fizanne, Lionel, Bassissi, Firas, Rachid, Madani, Tracz, Jennifer, Boursier, Jérôme, Courcambeck, Jérôme, Serdjebi, Cindy, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe, Brun, Sonia
Published in Therapeutic advances in chronic disease (2020)
Published in Therapeutic advances in chronic disease (2020)
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Journal Article
Mechanistic Basis for Reduced Viral and Enzymatic Fitness of HIV-1 Reverse Transcriptase Containing Both K65R and M184V Mutations
Deval, Jérôme, White, Kirsten L., Miller, Michael D., Parkin, Neil T., Courcambeck, Jérôme, Halfon, Philippe, Selmi, Boulbaba, Boretto, Joëlle, Canard, Bruno
Published in The Journal of biological chemistry (02.01.2004)
Published in The Journal of biological chemistry (02.01.2004)
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Journal Article
Resistance of hepatitis C virus to NS3-4A protease inhibitors : mechanisms of drug resistance induced by R155Q, A156T, D168A and D168V mutations
COURCOMBECK, Jérome, BOUZIDI, Mourad, PERBOST, Regis, JOUIROU, Besma, AMRONI, Nolwenn, CACOUB, Patrice, PEPE, Gérord, SABATIER, Jean-Marc, HOLFON, Philippe
Published in Antiviral therapy (01.01.2006)
Published in Antiviral therapy (01.01.2006)
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Journal Article
Abstract 1914: GNS561 is a new quinoline derivative with high efficacy on cancer stem cells from colorectal liver metastasis and hepatocellular carcinoma
Bassissi, Firas, Gifu, Elena Patricia, Brun, Sonia, Courcambeck, Jerome, Beret, Antoine, Pascussi, Jean Marc, Pannequin, Julie, Raymond, Eric, Halfon, Philippe, Merle, Philippe, Fromentel, Claude Caron de
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Preclinical characterization of GNS561 as a novel first in class autophagy inhibitor to kill hepatocellular carcinoma cancer stem cells
Bassissi, Firas, Brun, Sonia, Gifu, Elena Patricia, Courcambeck, Jerome, Nicolas, Gregory, Dubray, Clarisse, Beret, Antoine, Amrani, Nolwenn, Caron de Fromentel, Claude, Merle, Philippe, Halfon, Philippe
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
Abstract 5124: GNS561 a new quinoline derivative inhibits the growth of hepatocellular carcinoma in a cirrhotic rat and human PDX orthotopic mouse models
BASSISSI, Firas, Jilkova, Zuzana Macek, Brun, Sonia, Courcambeck, Jerome, Tracz, Jennifer, Kurma, Keerthi, Roth, Gaël S., Khaldi, Cindy, Chaimbault, Corinne, Quentin, Benoit, Asseraf, Emilie, Beret, Antoine, Raymond, Eric, Halfon, Philippe, Decaens, Thomas
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors
Bondada, Lavanya, Rondla, Ramu, Pradere, Ugo, Liu, Peng, Li, Chengwei, Bobeck, Drew, McBrayer, Tamara, Tharnish, Philip, Courcambeck, Jerome, Halfon, Philippe, Whitaker, Tony, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Journal Article
SUBSTITUTED 24 DIAMINO-QUINOLINE AS NEW ANTICANCER AGENTS
HALFON PHILIPPE, DUBRAY CLARISSE, BRUN SONIA, COURCAMBECK JEROME, BERET ANTOINE, BASSISSI FIRAS, NICOLAS GREGORY
Year of Publication 05.07.2017
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Year of Publication 05.07.2017
Patent
Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres
Rocheblave, Luc, Bihel, Frédéric, De Michelis, Céline, Priem, Ghislaine, Courcambeck, Jérôme, Bonnet, Brice, Chermann, Jean-Claude, Kraus, Jean-Louis
Published in Journal of medicinal chemistry (18.07.2002)
Published in Journal of medicinal chemistry (18.07.2002)
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Journal Article
QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS
HALFON PHILIPPE, BRUN SONIA, CAMUS CLAIRE, COURCAMBECK JEROME, BERET ANTOINE, NALLET JEAN PIERRE, BASSISSI FIRAS, NICOLAS GREGORY, PETIT SERGE
Year of Publication 25.11.2015
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Year of Publication 25.11.2015
Patent
SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW ANTICANCER AGENTS
DUBRAY, CLARISSE, BRUN, SONIA, NICOLAS, GREGORY, HALFON, PHILIPPE, BASSISSI, FIRAS, BERET, ANTOINE, COURCAMBECK, JEROME
Year of Publication 14.03.2023
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Year of Publication 14.03.2023
Patent
Design of potential new HIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates
Courcambeck, J, Bihel, F, De Michelis, C, Quelever, G, Kraus, JL
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
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Journal Article
Hepatitis C virus RNA load in relapsed patients: week two of treatment is the best time to predict the complete response
Halfon, Philippe, Khiri, Hacene, Tran, Albert, Pénaranda, Guillaume, Courcambeck, Jerome, Joly, Hélene, Ouzan, Denis
Published in European journal of gastroenterology & hepatology (01.10.2003)
Published in European journal of gastroenterology & hepatology (01.10.2003)
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Journal Article
SUBSTITUTED 2, 4-DIAMINO-QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES
COURCAMBECK Jerome, BASSISSI Firas, HALFON Philippe, BRUN Sonia, BERET Antoine
Year of Publication 30.04.2021
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Year of Publication 30.04.2021
Patent
"SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW ANTICANCER AGENTS"
DUBRAY, CLARISSE, BRUN, SONIA, NICOLAS, GREGORY, HALFON, PHILIPPE, BASSISSI, FIRAS, BERET, ANTOINE, COURCAMBECK, JEROME
Year of Publication 27.10.2022
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Year of Publication 27.10.2022
Patent