Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses
Goff, Peter H, Hayashi, Tomoko, Martínez-Gil, Luis, Corr, Maripat, Crain, Brian, Yao, Shiyin, Cottam, Howard B, Chan, Michael, Ramos, Irene, Eggink, Dirk, Heshmati, Mitra, Krammer, Florian, Messer, Karen, Pu, Minya, Fernandez-Sesma, Ana, Palese, Peter, Carson, Dennis A
Published in Journal of virology (01.03.2015)
Published in Journal of virology (01.03.2015)
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Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides
Shinchi, Hiroyuki, Crain, Brian, Yao, Shiyin, Chan, Michael, Zhang, Shannon S, Ahmadiiveli, Alast, Suda, Yasuo, Hayashi, Tomoko, Cottam, Howard B, Carson, Dennis A
Published in Bioconjugate chemistry (19.08.2015)
Published in Bioconjugate chemistry (19.08.2015)
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Structure–Activity Relationship Studies of Pyrimido[5,4‑b]indoles as Selective Toll-Like Receptor 4 Ligands
Chan, Michael, Kakitsubata, Yuhei, Hayashi, Tomoko, Ahmadi, Alast, Yao, Shiyin, Shukla, Nikunj M, Oyama, Shin-ya, Baba, Akihito, Nguyen, Brandon, Corr, Maripat, Suda, Yasuo, Carson, Dennis A, Cottam, Howard B, Wakao, Masahiro
Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
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Journal Article
Identification of Substituted Pyrimido[5,4‑b]indoles as Selective Toll-Like Receptor 4 Ligands
Chan, Michael, Hayashi, Tomoko, Mathewson, Richard D, Nour, Afshin, Hayashi, Yuki, Yao, Shiyin, Tawatao, Rommel I, Crain, Brian, Tsigelny, Igor F, Kouznetsova, Valentina L, Messer, Karen, Pu, Minya, Corr, Maripat, Carson, Dennis A, Cottam, Howard B
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia
Wu, Raymond P., Hayashi, Tomoko, Cottam, Howard B., Jin, Guangyi, Yao, Shiyin, Wu, Christina C. N., Rosenbach, Michael D., Corr, Maripat, Schwab, Richard B., Carson, Dennis A.
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
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Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands
Baba, Akihito, Wakao, Masahiro, Shinchi, Hiroyuki, Chan, Michael, Hayashi, Tomoko, Yao, Shiyin, Cottam, Howard B., Carson, Dennis A., Suda, Yasuo
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
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Molecular Basis for the Immunostimulatory Activity of Guanine Nucleoside Analogs: Activation of Toll-like Receptor 7
Lee, Jongdae, Chuang, Tsung-Hsien, Redecke, Vanessa, She, Liping, Pitha, Paula M., Carson, Dennis A., Raz, Eyal, Cottam, Howard B.
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2003)
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Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release
Shpigelman, Jonathan, Lao, Fitzgerald S, Yao, Shiyin, Li, Chenyang, Saito, Tetsuya, Sato-Kaneko, Fumi, Nolan, John P, Shukla, Nikunj M, Pu, Minya, Messer, Karen, Cottam, Howard B, Carson, Dennis A, Corr, Maripat, Hayashi, Tomoko
Published in Frontiers in pharmacology (16.04.2021)
Published in Frontiers in pharmacology (16.04.2021)
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Journal Article
A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity
Sato-Kaneko, Fumi, Yao, Shiyin, Lao, Fitzgerald S, Shpigelman, Jonathan, Messer, Karen, Pu, Minya, Shukla, Nikunj M, Cottam, Howard B, Chan, Michael, Chu, Paul J, Burkhart, David, Schoener, Roman, Matsutani, Takaji, Carson, Dennis A, Corr, Maripat, Hayashi, Tomoko
Published in Frontiers in immunology (19.06.2020)
Published in Frontiers in immunology (19.06.2020)
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Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes
Hayashi, Tomoko, Yao, Shiyin, Crain, Brian, Promessi, Victor J, Shyu, Luke, Sheng, Caroline, Kang, McNancy, Cottam, Howard B, Carson, Dennis A, Corr, Maripat
Published in PloS one (15.06.2015)
Published in PloS one (15.06.2015)
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Journal Article
Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses
Abdelwahab, Walid M, Auclair, Sarah, Borgogna, Timothy, Siram, Karthik, Riffey, Alexander, Bazin, Hélène G, Cottam, Howard B, Hayashi, Tomoko, Evans, Jay T, Burkhart, David J
Published in Pharmaceutics (01.01.2024)
Published in Pharmaceutics (01.01.2024)
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Activation of the Wnt Signaling Pathway in Chronic Lymphocytic Leukemia
Lu, Desheng, Zhao, Yandong, Tawatao, Rommel, Cottam, Howard B., Sen, Malini, Leoni, Lorenzo M., Kipps, Thomas J., Corr, Maripat, Carson, Dennis A.
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
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A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity
Shukla, Nikunj M, Sato-Kaneko, Fumi, Yao, Shiyin, Pu, Minya, Chan, Michael, Lao, Fitzgerald S, Sako, Yukiya, Saito, Tetsuya, Messer, Karen, Hayashi, Tomoko, Cottam, Howard B, Corr, Maripat, Carson, Dennis A
Published in Frontiers in pharmacology (11.04.2022)
Published in Frontiers in pharmacology (11.04.2022)
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Journal Article
Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge
Saito, Tetsuya, Sako, Yukiya, Sato-Kaneko, Fumi, Hosoya, Tadashi, Yao, Shiyin, Lao, Fitzgerald S, Shpigelman, Jonathan, Messer, Karen, Pu, Minya, Shukla, Nikunj M, Chan, Michael, Chu, Paul J, Cottam, Howard B, Hayashi, Tomoko, Carson, Dennis A, Corr, Maripat
Published in Frontiers in immunology (28.09.2021)
Published in Frontiers in immunology (28.09.2021)
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Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Hosoya, Tadashi, Shukla, Nikunj M, Fujita, Yuya, Yao, Shiyin, Lao, Fitzgerald S, Baba, Hiroyuki, Yasuda, Shinsuke, Cottam, Howard B, Carson, Dennis A, Hayashi, Tomoko, Corr, Maripat
Published in Frontiers in pharmacology (17.12.2020)
Published in Frontiers in pharmacology (17.12.2020)
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Journal Article
Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates
Chan, Michael, Hayashi, Tomoko, Kuy, Crystal S, Gray, Christine S, Wu, Christina C. N, Corr, Maripat, Wrasidlo, Wolfgang, Cottam, Howard B, Carson, Dennis A
Published in Bioconjugate chemistry (17.06.2009)
Published in Bioconjugate chemistry (17.06.2009)
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Activation of Anti-Hepatitis C Virus Responses via Toll-like Receptor 7
Lee, Jongdae, Wu, Christina C. N., Lee, Ki Jeong, Chuang, Tsung-Hsien, Katakura, Kyoko, Liu, Yu-Tsueng, Chan, Michael, Tawatao, Rommel, Chung, Michelle, Shen, Carol, Cottam, Howard B., Lai, Michael M. C., Raz, Eyal, Carson, Dennis A.
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
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Journal Article
A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination
Sato-Kaneko, Fumi, Yao, Shiyin, Lao, Fitzgerald S, Sako, Yukiya, Jin, Jasmine, Shukla, Nikunj M, Cottam, Howard B, Chan, Michael, Belsuzarri, Masiel M, Carson, Dennis A, Hayashi, Tomoko
Published in Vaccines (Basel) (01.10.2022)
Published in Vaccines (Basel) (01.10.2022)
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Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand
Wu, Christina C.N, Hayashi, Tomoko, Takabayashi, Kenji, Sabet, Mojgan, Smee, Donald F, Guiney, Donald D, Cottam, Howard B, Carson, Dennis A
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
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Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system
Hayashi, Tomoko, Yao, Shiyin, Crain, Brian, Chan, Michael, Tawatao, Rommel I, Gray, Christine, Vuong, Linda, Lao, Fitzgerald, Cottam, Howard B, Carson, Dennis A, Corr, Maripat
Published in PloS one (28.09.2012)
Published in PloS one (28.09.2012)
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