Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
Linciano, Pasquale, Cullia, Gregorio, Borsari, Chiara, Santucci, Matteo, Ferrari, Stefania, Witt, Gesa, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Santarém, Nuno, Cordeiro da Silva, Anabela, Conti, Paola, Bolognesi, Maria Laura, Roberti, Marinella, Prati, Federica, Bartoccini, Francesca, Retini, Michele, Piersanti, Giovanni, Cavalli, Andrea, Goldoni, Luca, Bertozzi, Sine Mandrup, Bertozzi, Fabio, Brambilla, Enzo, Rizzo, Vincenzo, Piomelli, Daniele, Pinto, Andrea, Bandiera, Tiziano, Costi, Maria Paola
Published in European journal of medicinal chemistry (01.03.2020)
Published in European journal of medicinal chemistry (01.03.2020)
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Journal Article
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth
Saxena, Puneet, Severi, Leda, Santucci, Matteo, Taddia, Laura, Ferrari, Stefania, Luciani, Rosaria, Marverti, Gaetano, Marraccini, Chiara, Tondi, Donatella, Mor, Marco, Scalvini, Laura, Vitiello, Simone, Losi, Lorena, Fonda, Sergio, Pacifico, Salvatore, Guerrini, Remo, D’Arca, Domenico, Ponterini, Glauco, Costi, Maria Paola
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article
The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase
Gonzalez-Pacanowska, Dolores, Ruiz-Perez, Luis M, Carreras-Gómez, María Angeles, Costi, Maria Paola, Stroud, Robert M, Finer-Moore, Janet, Santi, Daniel V
Published in Protein engineering (01.08.2003)
Published in Protein engineering (01.08.2003)
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Journal Article
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
Uliassi, Elisa, Fiorani, Giulia, Krauth-Siegel, R. Luise, Bergamini, Christian, Fato, Romana, Bianchini, Giulia, Carlos Menéndez, J., Molina, Maria Teresa, López-Montero, Eulogio, Falchi, Federico, Cavalli, Andrea, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Witt, Gesa, Moraes, Carolina B., Freitas-Junior, Lucio H., Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura
Published in European journal of medicinal chemistry (01.12.2017)
Published in European journal of medicinal chemistry (01.12.2017)
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Journal Article
Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use
Lima, Clara M., Uliassi, Elisa, Thoré, Eli S.J., Bertram, Michael G., Cardoso, Luis, Cordeiro da Silva, Anabela, Costi, Maria Paola, de Koning, Harry P.
Published in Open research Europe (2024)
Published in Open research Europe (2024)
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Journal Article
Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use
Lima, Clara M., Uliassi, Elisa, Thoré, Eli S.J., Bertram, Michael G., Cardoso, Luis, Cordeiro da Silva, Anabela, Costi, Maria Paola, de Koning, Harry P.
Published in Open research Europe (2024)
Published in Open research Europe (2024)
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Journal Article
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones?
Sacchetti, Francesca, D'Arca, Domenico, Genovese, Filippo, Pacifico, Salvatore, Maretti, Eleonora, Hanuskova, Miriam, Iannuccelli, Valentina, Costi, Maria Paola, Leo, Eliana
Published in Drug development and industrial pharmacy (04.03.2017)
Published in Drug development and industrial pharmacy (04.03.2017)
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Journal Article
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs
Borsari, Chiara, Luciani, Rosaria, Pozzi, Cecilia, Poehner, Ina, Henrich, Stefan, Trande, Matteo, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Baptista, Catarina, Tait, Annalisa, Di Pisa, Flavio, Dello Iacono, Lucia, Landi, Giacomo, Gul, Sheraz, Wolf, Markus, Kuzikov, Maria, Ellinger, Bernhard, Reinshagen, Jeanette, Witt, Gesa, Gribbon, Philip, Kohler, Manfred, Keminer, Oliver, Behrens, Birte, Costantino, Luca, Tejera Nevado, Paloma, Bifeld, Eugenia, Eick, Julia, Clos, Joachim, Torrado, Juan, Jiménez-Antón, María D, Corral, María J, Alunda, José Ma, Pellati, Federica, Wade, Rebecca C, Ferrari, Stefania, Mangani, Stefano, Costi, Maria Paola
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
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Journal Article
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery
Sacchetti, Francesca, Marraccini, Chiara, D’Arca, Domenico, Pelà, Michela, Pinetti, Diego, Maretti, Eleonora, Hanuskova, Miriam, Iannuccelli, Valentina, Costi, Maria Paola, Leo, Eliana
Published in Colloids and surfaces, B, Biointerfaces (01.12.2015)
Published in Colloids and surfaces, B, Biointerfaces (01.12.2015)
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Journal Article
Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors
Tondi, Donatella, Calò, Samuele, Shoichet, Brian K., Costi, Maria Paola
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Journal Article
Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma
D'Arca, Domenico, Severi, Leda, Ferrari, Stefania, Dozza, Luca, Marverti, Gaetano, Magni, Fulvio, Chinello, Clizia, Pagani, Lisa, Tagliazucchi, Lorenzo, Villani, Marco, d'Addese, Gianluca, Piga, Isabella, Conteduca, Vincenza, Rossi, Lorena, Gurioli, Giorgia, De Giorgi, Ugo, Losi, Lorena, Costi, Maria Paola
Published in Cancers (08.01.2023)
Published in Cancers (08.01.2023)
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Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP‑1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania infantum Clinical Isolates
Tagliazucchi, Lorenzo, Perea-Martinez, Ana, Fiorini, Greta, Manzano, José Ignacio, Genovese, Filippo, García-Hernández, Raquel, Pinetti, Diego, Gamarro, Francisco, Costi, Maria Paola
Published in ACS infectious diseases (10.03.2023)
Published in ACS infectious diseases (10.03.2023)
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Journal Article
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations
Pozzi, Cecilia, Santucci, Matteo, Marverti, Gaetano, D'Arca, Domenico, Tagliazucchi, Lorenzo, Ferrari, Stefania, Gozzi, Gaia, Losi, Lorena, Tassone, Giusy, Mangani, Stefano, Ponterini, Glauco, Costi, Maria Paola
Published in Cancers (24.04.2021)
Published in Cancers (24.04.2021)
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Journal Article
Molecular basis for covalent inhibition of glyceraldehyde‐3‐phosphate dehydrogenase by a 2‐phenoxy‐1,4‐naphthoquinone small molecule
Bruno, Stefano, Uliassi, Elisa, Zaffagnini, Mirko, Prati, Federica, Bergamini, Christian, Amorati, Riccardo, Paredi, Gianluca, Margiotta, Marilena, Conti, Paola, Costi, Maria Paola, Kaiser, Marcel, Cavalli, Andrea, Fato, Romana, Bolognesi, Maria Laura
Published in Chemical biology & drug design (01.08.2017)
Published in Chemical biology & drug design (01.08.2017)
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