Search Results - "COSFORD, NICHOLAS D.P" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

by Egan, Daniel F., Chun, Matthew G.H., Vamos, Mitchell, Zou, Haixia, Rong, Juan, Miller, Chad J., Lou, Hua Jane, Raveendra-Panickar, Dhanya, Yang, Chih-Cheng, Sheffler, Douglas J., Teriete, Peter, Asara, John M., Turk, Benjamin E., Cosford, Nicholas D.P., Shaw, Reuben J.
Published in Molecular cell (16.07.2015)

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Journal Article

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

by Kim, InKi, Shu, Chih-Wen, Xu, Wenjie, Shiau, Chung-Wai, Grant, Daniel, Vasile, Stefan, Cosford, Nicholas D.P., Reed, John C.
Published in The Journal of biological chemistry (16.01.2009)

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Journal Article

[ 3H]-Methoxymethyl-MTEP and [ 3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

[ 3H]-Methoxymethyl-MTEP and [ 3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

by Cosford, Nicholas D.P, Roppe, Jeffrey, Tehrani, Lida, Schweiger, Edwin J, Seiders, T.Jon, Chaudary, Ashok, Rao, Sara, Varney, Mark A
Published in Bioorganic & medicinal chemistry letters (10.02.2003)

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HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

by Johnston, Paul A, Phillips, Jennifer, Shun, Tong Ying, Shinde, Sunita, Lazo, John S, Huryn, Donna M, Myers, Michael C, Ratnikov, Boris I, Smith, Jeffrey W, Su, Ying, Dahl, Russell, Cosford, Nicholas D P, Shiryaev, Sergey A, Strongin, Alex Y
Published in Assay and drug development technologies (01.12.2007)

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BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

by Pache, Lars, Dutra, Miriam S., Spivak, Adam M., Marlett, John M., Murry, Jeffrey P., Hwang, Young, Maestre, Ana M., Manganaro, Lara, Vamos, Mitchell, Teriete, Peter, Martins, Laura J., König, Renate, Simon, Viviana, Bosque, Alberto, Fernandez-Sesma, Ana, Cosford, Nicholas D.P., Bushman, Frederic D., Young, John A.T., Planelles, Vicente, Chanda, Sumit K.
Published in Cell host & microbe (09.09.2015)

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Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

by Pinkerton, Anthony B., Sergienko, Eduard, Bravo, Yalda, Dahl, Russell, Ma, Chen-Ting, Sun, Qing, Jackson, Michael R., Cosford, Nicholas D.P., Millán, José Luis
Published in Bioorganic & medicinal chemistry letters (01.01.2018)

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Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

by Noberini, Roberta, Koolpe, Mitchell, Peddibhotla, Satyamaheshwar, Dahl, Russell, Su, Ying, Cosford, Nicholas D.P., Roth, Gregory P., Pasquale, Elena B.
Published in The Journal of biological chemistry (24.10.2008)

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Translational enhancers of EAAT2: therapeutic implications for neurodegenerative disease

Translational enhancers of EAAT2: therapeutic implications for neurodegenerative disease

by Limpert, Allison S, Cosford, Nicholas D P
Published in The Journal of clinical investigation (01.03.2014)

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Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

by Pache, Lars, Marsden, Matthew D., Teriete, Peter, Portillo, Alex J., Heimann, Dominik, Kim, Jocelyn T., Soliman, Mohamed S.A., Dimapasoc, Melanie, Carmona, Camille, Celeridad, Maria, Spivak, Adam M., Planelles, Vicente, Cosford, Nicholas D.P., Zack, Jerome A., Chanda, Sumit K.
Published in Cell reports. Medicine (23.06.2020)

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Preclinical Studies of Celastrol and Acetyl Isogambogic Acid in Melanoma

Preclinical Studies of Celastrol and Acetyl Isogambogic Acid in Melanoma

by ABBAS, Sabiha, BHOUMIK, Anindita, DAHL, Russell, VASILE, Stefan, KRAJEWSKI, Stan, COSFORD, Nicholas D. P, RONAI, Zeev A
Published in Clinical cancer research (15.11.2007)

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Phosphomannose Isomerase Inhibitors Improve N-Glycosylation in Selected Phosphomannomutase-deficient Fibroblasts

Phosphomannose Isomerase Inhibitors Improve N-Glycosylation in Selected Phosphomannomutase-deficient Fibroblasts

by Sharma, Vandana, Ichikawa, Mie, He, Ping, Bravo, Yalda, Dahl, Russell, Ng, Bobby G., Cosford, Nicholas D.P., Freeze, Hudson H.
Published in The Journal of biological chemistry (11.11.2011)

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Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABAA signaling

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABAA signaling

by Klodzinska, Aleksandra, Tatarczyńska, Ewa, Chojnacka-Wójcik, Ewa, Nowak, Gabriel, Cosford, Nicholas D.P, Pilc, Andrzej
Published in Neuropharmacology (01.09.2004)

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AMYLOID PRECURSOR PROTEIN C-TERMINAL CLEAVAGE RESULTING IN THE TOXIC C31 PEPTIDE: STIMULATION OF CLEAVAGE WITH CEREVASTATIN AND INHIBITION AND CELL VIABILITY RESCUE USING SMALL MOLECULES

AMYLOID PRECURSOR PROTEIN C-TERMINAL CLEAVAGE RESULTING IN THE TOXIC C31 PEPTIDE: STIMULATION OF CLEAVAGE WITH CEREVASTATIN AND INHIBITION AND CELL VIABILITY RESCUE USING SMALL MOLECULES

by Poksay, Karen S, Sheffler, Douglas J, Campagna, Jesus, Spilman, Patricia, Mullenix, Michael, Bredesen, Dale E, Cosford, Nicholas D.P, John, Varghese
Published in Alzheimer's & dementia (01.07.2016)

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Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

by Haass-Koffler, Carolina L., Francis, T. Chase, Gandhi, Pauravi, Patel, Reesha, Naemuddin, Mohammad, Nielsen, Carsten K., Bartlett, Selena E., Bonci, Antonello, Vasile, Stefan, Hood, Becky L., Suyama, Eigo, Hedrick, Michael P., Smith, Layton H., Limpert, Allison S., Roberto, Marisa, Cosford, Nicholas D.P., Sheffler, Douglas J.
Published in SLAS discovery (01.12.2022)

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Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP

by Ardecky, Robert J., Welsh, Kate, Finlay, Darren, Lee, Pooi San, González-López, Marcos, Ganji, Santhi Reddy, Ravanan, Palaniyandi, Mace, Peter D., Riedl, Stefan J., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)

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Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP

by González-Lόpez, Marcos, Welsh, Kate, Finlay, Darren, Ardecky, Robert J., Ganji, Santhi Reddy, Su, Ying, yuan, Hongbin, Teriete, Peter, Mace, Peter D., Riedl, Stefan J., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.07.2011)

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Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

by Hamill, Terence G., Krause, Stephen, Ryan, Christine, Bonnefous, Celine, Govek, Steve, Seiders, T. Jon, Cosford, Nicholas D.P., Roppe, Jeffrey, Kamenecka, Ted, Patel, Shil, Gibson, Raymond E., Sanabria, Sandra, Riffel, Kerry, Eng, Waisi, King, Christopher, Yang, Xiaoqing, Green, Mitchell D., O'malley, Stacey S., Hargreaves, Richard, Burns, H. Donald
Published in Synapse (New York, N.Y.) (15.06.2005)

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In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [ 3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [ 3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine

by Anderson, Jeffery J., Bradbury, Margaret J., Giracello, Darlene R., Chapman, Deborah F., Holtz, Greg, Roppe, Jeffrey, King, Chris, Cosford, Nicholas D.P., Varney, Mark A.
Published in European journal of pharmacology (18.07.2003)

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Journal Article

마크로시클릭 ULK1/2 억제제

마크로시클릭 ULK1/2 억제제

by BAKAS NICOLE A, COSFORD NICHOLAS D.P, LIMPERT ALLISON S, BRUN SONJA N, SHAW REUBEN J
Year of Publication 18.11.2022

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Patent

ULK1/2 억제제를 이용한 단일 및 병용 요법

ULK1/2 억제제를 이용한 단일 및 병용 요법

by BAKAS NICOLE A, COSFORD NICHOLAS D.P, LIMPERT ALLISON S, BRUN SONJA N, VAMOS MITCHELL, SHAW REUBEN J
Year of Publication 21.11.2022

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Patent

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