Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer
Ren, Huiyu, Bakas, Nicole A, Vamos, Mitchell, Chaikuad, Apirat, Limpert, Allison S, Wimer, Carina D, Brun, Sonja N, Lambert, Lester J, Tautz, Lutz, Celeridad, Maria, Sheffler, Douglas J, Knapp, Stefan, Shaw, Reuben J, Cosford, Nicholas D. P
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia
Bata, Nicole, Chaikuad, Apirat, Bakas, Nicole A, Limpert, Allison S, Lambert, Lester J, Sheffler, Douglas J, Berger, Lena M, Liu, Guoxiong, Yuan, Cunxiang, Wang, Li, Peng, Yi, Dong, Jing, Celeridad, Maria, Layng, Fabiana, Knapp, Stefan, Cosford, Nicholas D. P
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Perturbation of the c‑Myc–Max Protein–Protein Interaction via Synthetic α‑Helix Mimetics
Jung, Kwan-Young, Wang, Huabo, Teriete, Peter, Yap, Jeremy L, Chen, Lijia, Lanning, Maryanna E, Hu, Angela, Lambert, Lester J, Holien, Toril, Sundan, Anders, Cosford, Nicholas D. P, Prochownik, Edward V, Fletcher, Steven
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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Identification and Development of a New Positron Emission Tomography Ligand 4‑(2-Fluoro-4‑[11C]methoxyphenyl)-5-((1-methyl‑1H‑pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2)
Yamasaki, Tomoteru, Zhang, Xiaofei, Kumata, Katsushi, Zhang, Yiding, Deng, Xiaoyun, Fujinaga, Masayuki, Chen, Zhen, Mori, Wakana, Hu, Kuan, Wakizaka, Hidekatsu, Hatori, Akiko, Xie, Lin, Ogawa, Masanao, Nengaki, Nobuki, Van, Richard, Shao, Yihan, Sheffler, Douglas J, Cosford, Nicholas D. P, Liang, Steven H, Zhang, Ming-Rong
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence
Grant, Daniel, Dahl, Russell, Cosford, Nicholas D. P
Published in Journal of organic chemistry (19.09.2008)
Published in Journal of organic chemistry (19.09.2008)
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Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins
Finlay, Darren, Teriete, Peter, Vamos, Mitchell, Cosford, Nicholas D P, Vuori, Kristiina
Published in F1000 research (2017)
Published in F1000 research (2017)
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Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype‑2 and -3 (mGlu2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence
Dhanya, Raveendra-Panickar, Sheffler, Douglas J, Dahl, Russell, Davis, Melinda, Lee, Pooi San, Yang, Li, Nickols, Hilary Highfield, Cho, Hyekyung P, Smith, Layton H, D’Souza, Manoranjan S, Conn, P. Jeffrey, Der-Avakian, Andre, Markou, Athina, Cosford, Nicholas D. P
Published in Journal of medicinal chemistry (22.05.2014)
Published in Journal of medicinal chemistry (22.05.2014)
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Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
Welsh, Kate, Milutinovic, Snezana, Ardecky, Robert J, Gonzalez-Lopez, Marcos, Ganji, Santhi Reddy, Teriete, Peter, Finlay, Darren, Riedl, Stefan, Matsuzawa, Shu-Ichi, Pinilla, Clemencia, Houghten, Richard, Vuori, Kristiina, Reed, John C, Cosford, Nicholas D P
Published in PloS one (12.09.2016)
Published in PloS one (12.09.2016)
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Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo
Yue, Peibin, Zhu, Yinsong, Brotherton-Pleiss, Christine, Fu, Wenzhen, Verma, Nagendra, Chen, Jasmine, Nakamura, Kayo, Chen, Weiliang, Chen, Yue, Alonso-Valenteen, Felix, Mikhael, Simoun, Medina-Kauwe, Lali, Kershaw, Kathleen M., Celeridad, Maria, Pan, Songqin, Limpert, Allison S., Sheffler, Douglas J., Cosford, Nicholas D.P., Shiao, Stephen L., Tius, Marcus A., Lopez-Tapia, Francisco, Turkson, James
Published in Cancer letters (28.05.2022)
Published in Cancer letters (28.05.2022)
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Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
Sidique, Shyama, Ardecky, Robert, Su, Ying, Narisawa, Sonoko, Brown, Brock, Millán, José Luis, Sergienko, Eduard, Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
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Discovery and Validation of a Series of Aryl Sulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP)
Dahl, Russell, Sergienko, Eduard A, Su, Ying, Mostofi, Yalda S, Yang, Li, Simao, Ana Maria, Narisawa, Sonoko, Brown, Brock, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Smith, Layton H, O’Neill, W. Charles, Millán, José Luis, Cosford, Nicholas D. P
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7‑((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4‑[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2
Zhang, Xiaofei, Kumata, Katsushi, Yamasaki, Tomoteru, Cheng, Ran, Hatori, Akiko, Ma, Longle, Zhang, Yiding, Xie, Lin, Wang, Lu, Kang, Hye Jin, Sheffler, Douglas J, Cosford, Nicholas D. P, Zhang, Ming-Rong, Liang, Steven H
Published in ACS chemical neuroscience (20.09.2017)
Published in ACS chemical neuroscience (20.09.2017)
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Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
Sidique, Shyama, Shiryaev, Sergey A., Ratnikov, Boris I., Herath, Ananda, Su, Ying, Strongin, Alex Y., Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
Wang, Huabo, Teriete, Peter, Hu, Angela, Raveendra-Panickar, Dhanya, Pendelton, Kelsey, Lazo, John S, Eiseman, Julie, Holien, Toril, Misund, Kristine, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Cosford, Nicholas D P, Sundan, Anders, Prochownik, Edward V
Published in Oncotarget (20.10.2015)
Published in Oncotarget (20.10.2015)
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3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity
Cosford, Nicholas D. P, Tehrani, Lida, Roppe, Jeffrey, Schweiger, Edwin, Smith, Nicholas D, Anderson, Jeffrey, Bristow, Linda, Brodkin, Jesse, Jiang, Xiaohui, McDonald, Ian, Rao, Sara, Washburn, Mark, Varney, Mark A
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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