Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
Dilger, Andrew K, Pabbisetty, Kumar B, Corte, James R, De Lucca, Indawati, Fang, Tianan, Yang, Wu, Pinto, Donald J. P, Wang, Yufeng, Zhu, Yeheng, Mathur, Arvind, Li, Jianqing, Hou, Xiaoping, Smith, Daniel, Sun, Dawn, Zhang, Huiping, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Myers, Joseph E, Sheriff, Steven, Rossi, Karen A, Chacko, Silvi, Zheng, Joanna J, Galella, Michael A, Ziemba, Theresa, Dierks, Elizabeth A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl, Wong, Pancras C, Luettgen, Joseph M, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (10.02.2022)
Published in Journal of medicinal chemistry (10.02.2022)
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Methyl-2,2-difluoro-2-(fluorosulfonyl) acetate (MDFA)/copper (I) iodide mediated and tetrabutylammonium iodide promoted trifluoromethylation of 1-aryl-4-iodo-1,2,3-triazoles
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Published in Journal of fluorine chemistry (01.08.2020)
Published in Journal of fluorine chemistry (01.08.2020)
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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker
Corte, James R, Fang, Tianan, Osuna, Honey, Pinto, Donald J. P, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Harper, Timothy W, Bozarth, Jeffrey M, Wu, Yiming, Luettgen, Joseph M, Seiffert, Dietmar A, Decicco, Carl P, Wexler, Ruth R, Quan, Mimi L
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species
Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Corte, James R, Fang, Tianan, Gilligan, Paul J, Jeon, Yoon, Pabbisetty, Kumar B, Rampulla, Richard A, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Arumugam, Arunachalam, Raju, Sivashankaran, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Chacko, Silvi A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl J, Wong, Pancras C, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
Corte, James R, Pinto, Donald J. P, Fang, Tianan, Osuna, Honey, Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Sun, Jung-Hui, Rampulla, Richard, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Li, Yi-Xin Cindy, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Harper, Timothy W, Huang, Christine, Zheng, Joanna J, Bozarth, Jeffrey M, Wu, Yiming, Wong, Pancras C, Crain, Earl J, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Macrocyclic factor XIa inhibitors
Wang, Cailan, Corte, James R., Rossi, Karen A., Bozarth, Jeffrey M., Wu, Yiming, Sheriff, Steven, Myers, Joseph E., Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
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Journal Article
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa
Fang, Tianan, Corte, James R., Gilligan, Paul J., Jeon, Yoon, Osuna, Honey, Rossi, Karen A., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Zheng, Joanna J., Harper, Timothy W., Bozarth, Jeffrey M., Wu, Yiming, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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Journal Article
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability
Clark, Charles G., Rossi, Karen A., Corte, James R., Fang, Tianan, Smallheer, Joanne M., De Lucca, Indawati, Nirschl, David S., Orwat, Michael J., Pinto, Donald J.P., Hu, Zilun, Wang, Yufeng, Yang, Wu, Jeon, Yoon, Ewing, William R., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Bozarth, Jeffrey M., Wu, Yiming, Rendina, Alan, Harper, Timothy, Zheng, Joanna, Xin, Baomin, Xiang, Qian, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
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Journal Article
Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity
Hangeland, Jon J, Friends, Todd J, Rossi, Karen A, Smallheer, Joanne M, Wang, Cailan, Sun, Zhong, Corte, James R, Fang, Tianan, Wong, Pancras C, Rendina, Alan R, Barbera, Frank A, Bozarth, Jeffrey M, Luettgen, Joseph M, Watson, Carol A, Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E, Bisacchi, Gregory S, Subramaniam, Srinath, Arunachalam, Piramanayagam, Mathur, Arvind, Seiffert, Dietmar A, Wexler, Ruth R, Quan, Mimi L
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency
Corte, James R., Yang, Wu, Fang, Tianan, Wang, Yufeng, Osuna, Honey, Lai, Amy, Ewing, William R., Rossi, Karen A., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Zheng, Joanna J., Harper, Timothy W., Bozarth, Jeffrey M., Wu, Yiming, Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group
Corte, James R., Fang, Tianan, Pinto, Donald J.P., Orwat, Michael J., Rendina, Alan R., Luettgen, Joseph M., Rossi, Karen A., Wei, Anzhi, Ramamurthy, Vidhyashankar, Myers, Joseph E., Sheriff, Steven, Narayanan, Rangaraj, Harper, Timothy W., Zheng, Joanna J., Li, Yi-Xin, Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry (15.05.2016)
Published in Bioorganic & medicinal chemistry (15.05.2016)
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Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties
Pinto, Donald J.P., Smallheer, Joanne M., Corte, James R., Austin, Erin J.D., Wang, Cailan, Fang, Tianan, Smith, Leon M., Rossi, Karen A., Rendina, Alan R., Bozarth, Jeffrey M., Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Sheriff, Steven, Myers, Joseph E., Morin, Paul E., Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Journal Article
Novel phenylalanine derived diamides as Factor XIa inhibitors
Smith, Leon M., Orwat, Michael J., Hu, Zilun, Han, Wei, Wang, Cailan, Rossi, Karen A., Gilligan, Paul J., Pabbisetty, Kumar B., Osuna, Honey, Corte, James R., Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., Narayanan, Ranga, Harper, Timothy W., Bozarth, Jeffrey M., Crain, Earl J., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Xin, Baomin, Zheng, Joanna, Seiffert, Dietmar A., Quan, Mimi L., Lam, Patrick Y.S., Wexler, Ruth R., Pinto, Donald J.P.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Journal Article
Pyridine and pyridinone-based factor XIa inhibitors
Corte, James R., Fang, Tianan, Hangeland, Jon J., Friends, Todd J., Rendina, Alan R., Luettgen, Joseph M., Bozarth, Jeffrey M., Barbera, Frank A., Rossi, Karen A., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Characterization of a new class of selective nonsteroidal progesterone receptor agonists
Dong, Yu, Roberge, Jacques Y, Wang, Zhaoqing, Wang, Xiaodong, Tamasi, Joseph, Dell, Vanessa, Golla, Rajasree, Corte, James R, Liu, Yalei, Fang, Tianan, Anthony, Monique N, Schnur, Dora M, Agler, Michele L, Dickson, John K, Lawrence, R.Michael, Prack, Margaret M, Seethala, Ramakrishna, Feyen, Jean H.M
Published in Steroids (01.03.2004)
Published in Steroids (01.03.2004)
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Synthesis and Characterization of 3-Arylquinazolinone and 3-Arylquinazolinethione Derivatives as Selective Estrogen Receptor Beta Modulators
Güngör, Timur, Chen, Ying, Golla, Rajasree, Ma, Zhengping, Corte, James R., Northrop, John P., Bin, Dickson, John K., Stouch, Terry, Zhou, Rong, Johnson, Susan E., Seethala, Ramakrishna, Feyen, Jean H. M.
Published in Journal of medicinal chemistry (20.04.2006)
Published in Journal of medicinal chemistry (20.04.2006)
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Structure–activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties
Corte, James R., Fang, Tianan, Pinto, Donald J.P., Han, Wei, Hu, Zilun, Jiang, Xiang-Jun, Li, Yun-Long, Gauuan, Jolicia F., Hadden, Mark, Orton, Darren, Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., He, Kan, Morin, Paul E., Chang, Chong-Hwan, Cheney, Daniel L., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
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LPA1 수용체를 영상화하기 위한 방사성리간드
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Year of Publication 23.06.2021
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Year of Publication 23.06.2021
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XIa P2' MACROCYCLES WITH HETROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS
SMITH LEON M. II, WEXLER RUTH R, ZHU YEHENG, ORWAT MICHAEL J, PINTO DONALD J. P, DE LUCCA INDAWATI, PABBISETTY KUMAR BALASHANMUGA, FANG TIANAN, WANG YUFENG, DILGER ANDREW K, EWING WILLIAM R, CORTE JAMES R, YANG WU
Year of Publication 06.02.2024
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Year of Publication 06.02.2024
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