Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Chamberlain, Philip P, Lopez-Girona, Antonia, Miller, Karen, Carmel, Gilles, Pagarigan, Barbra, Chie-Leon, Barbara, Rychak, Emily, Corral, Laura G, Ren, Yan J, Wang, Maria, Riley, Mariko, Delker, Silvia L, Ito, Takumi, Ando, Hideki, Mori, Tomoyuki, Hirano, Yoshinori, Handa, Hiroshi, Hakoshima, Toshio, Daniel, Thomas O, Cathers, Brian E
Published in Nature structural & molecular biology (01.09.2014)
Published in Nature structural & molecular biology (01.09.2014)
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Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
Chen, Qing, Xie, Weilin, Kuhn, Deborah J., Voorhees, Peter M., Lopez-Girona, Antonia, Mendy, Derek, Corral, Laura G., Krenitsky, Veronique Plantevin, Xu, Weiming, Moutouh-de Parseval, Laure, Webb, David R., Mercurio, Frank, Nakayama, Keiichi I., Nakayama, Keiko, Orlowski, Robert Z.
Published in Blood (01.05.2008)
Published in Blood (01.05.2008)
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Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
VERHELLE, Dominique, CORRAL, Laura G, LOPEZ-GIRONA, Antonia, MUTTER, George W, BRADY, Helen A, CHAN, Kyle W. H, WONG, Kevin, MUELLER, Jessica H, MOUTOUH-DE PARSEVAL, Laure, JENSEN-PERGAKES, Kristen, SCHAFER, Peter H, CHEN, Roger, GLEZER, Emilia, FERGUSON, Gregory D
Published in Cancer research (Chicago, Ill.) (15.01.2007)
Published in Cancer research (Chicago, Ill.) (15.01.2007)
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Journal Article
Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases
Xu, Yibing, Li, Jianwu, Ferguson, Gregory D., Mercurio, Frank, Khambatta, Gody, Morrison, Lisa, Lopez-Girona, Antonia, Corral, Laura G., Webb, David R., Bennett, Brydon L., Xie, Weilin
Published in Blood (09.07.2009)
Published in Blood (09.07.2009)
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Journal Article
Enhancement of Cytokine Production and AP-1 Transcriptional Activity in T Cells by Thalidomide-Related Immunomodulatory Drugs
Schafer, Peter H, Gandhi, Anita K, Loveland, Michelle A, Chen, Roger S, Man, Hon-Wah, Schnetkamp, Paul P M, Wolbring, Gregor, Govinda, Sowmya, Corral, Laura G, Payvandi, Faribourz, Muller, George W, Stirling, David I
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
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Journal Article
Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53
Fecteau, Jessie-F, Corral, Laura G, Ghia, Emanuela M, Gaidarova, Svetlana, Futalan, Diahnn, Bharati, Ila Sri, Cathers, Brian, Schwaederlé, Maria, Cui, Bing, Lopez-Girona, Antonia, Messmer, Davorka, Kipps, Thomas J
Published in Blood (04.09.2014)
Published in Blood (04.09.2014)
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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor
Man, Hon-Wah, Schafer, Peter, Wong, Lu Min, Patterson, Rebecca T, Corral, Laura G, Raymon, Heather, Blease, Kate, Leisten, Jim, Shirley, Michael A, Tang, Yang, Babusis, Darius M, Chen, Roger, Stirling, Dave, Muller, George W
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Journal Article
Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor
MAN, Hon-Wah, SCHAFER, Peter, BABUSIS, Darius M, CHEN, Roger, STIRLING, Dave, MULLER, George W, LU MIN WONG, PATTERSON, Rebecca T, CORRAL, Laura G, RAYMON, Heather, BLEASE, Kate, LEISTEN, Jim, SHIRLEY, Michael A, YANG TANG
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Journal Article
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells
Moutouh-de Parseval, Laure A, Verhelle, Dominique, Glezer, Emilia, Jensen-Pergakes, Kristen, Ferguson, Gregory D, Corral, Laura G, Morris, Christopher L, Muller, George, Brady, Helen, Chan, Kyle
Published in The Journal of clinical investigation (01.01.2008)
Published in The Journal of clinical investigation (01.01.2008)
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Journal Article
A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure
Bradley, Jessica M, Spaletra, Pablo, Li, Zhen, Sharp, 3rd, Thomas E, Goodchild, Traci T, Corral, Laura G, Fung, Leah, Chan, Kyle W H, Sullivan, Robert W, Swindlehurst, Cathy A, Lefer, David J
Published in American journal of physiology. Heart and circulatory physiology (01.09.2018)
Published in American journal of physiology. Heart and circulatory physiology (01.09.2018)
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Journal Article
Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice
Meiler, Steffen E., Wade, Marlene, Kutlar, Ferdane, Yerigenahally, Shobha D., Xue, Yongjun, Moutouh-de Parseval, Laure A., Corral, Laura G., Swerdlow, Paul S., Kutlar, Abdullah
Published in Blood (28.07.2011)
Published in Blood (28.07.2011)
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Journal Article
Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21WAF1/Cip1-dependent mechanism independent of functional p53
Fecteau, Jessie-F., Corral, Laura G., Ghia, Emanuela M., Gaidarova, Svetlana, Futalan, Diahnn, Bharati, Ila Sri, Cathers, Brian, Schwaederlé, Maria, Cui, Bing, Lopez-Girona, Antonia, Messmer, Davorka, Kipps, Thomas J.
Published in Blood (04.09.2014)
Published in Blood (04.09.2014)
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Journal Article
α-Fluoro-substituted thalidomide analogues
MAN, Hon-Wah, CORRAL, Laura G, STIRLING, David I, MULLER, George W
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2
Ferguson, Gregory D, Jensen-Pergakes, Kristen, Wilkey, Candice, Jhaveri, Urvi, Richard, Normand, Verhelle, Dominique, De Parseval, Laure Moutouh, Corral, Laura G, Xie, Weilin, Morris, Christopher L, Brady, Helen, Chan, Kyle
Published in Journal of Clinical Immunology (01.03.2007)
Published in Journal of Clinical Immunology (01.03.2007)
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Journal Article
Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity
Muller, George W, Corral, Laura G, Shire, Mary G, Wang, Hua, Moreira, Andre, Kaplan, Gilla, Stirling, David I
Published in Journal of medicinal chemistry (16.08.1996)
Published in Journal of medicinal chemistry (16.08.1996)
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Abstract LB-211: Synergistic anti-metastatic effect of pembrolizumab in combination with a novel mTORC1 inhibitor/AMPK agonist in a CAM metastatic triple negative breast cancer model
Fung, Leah, Corral, Laura G., Sullivan, Robert W., Chan, Kyle W., Swindlehurst, Cathy A.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 3341: Targeting CXCR4 via the small molecule inhibitor NMX1 as a therapeutic strategy to treat high-risk malignancies
Sipila, Patrick, Tran, Son, Zhang, Chunfen, Corral, Laura G., Chan, Kyle W., Swindlehurst, Cathy A., Narendran, Aru
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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