Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease
Marshall, John, Ashe, Karen M, Bangari, Dinesh, McEachern, KerryAnne, Chuang, Wei-Lien, Pacheco, Joshua, Copeland, Diane P, Desnick, Robert J, Shayman, James A, Scheule, Ronald K, Cheng, Seng H
Published in PloS one (24.11.2010)
Published in PloS one (24.11.2010)
Get full text
Journal Article
Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease
Ashe, Karen M, Bangari, Dinesh, Li, Lingyun, Cabrera-Salazar, Mario A, Bercury, Scott D, Nietupski, Jennifer B, Cooper, Christopher G F, Aerts, Johannes M F G, Lee, Edward R, Copeland, Diane P, Cheng, Seng H, Scheule, Ronald K, Marshall, John
Published in PloS one (29.06.2011)
Published in PloS one (29.06.2011)
Get full text
Journal Article
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease
McEachern, Kerry Anne, Fung, John, Komarnitsky, Svetlana, Siegel, Craig S., Chuang, Wei-Lien, Hutto, Elizabeth, Shayman, James A., Grabowski, Gregory A., Aerts, Johannes M.F.G., Cheng, Seng H., Copeland, Diane P., Marshall, John
Published in Molecular genetics and metabolism (01.07.2007)
Published in Molecular genetics and metabolism (01.07.2007)
Get full text
Journal Article
Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann–Pick C mice
Nietupski, Jennifer B., Pacheco, Joshua J., Chuang, Wei-Lien, Maratea, Kimberly, Li, Lingyun, Foley, Joseph, Ashe, Karen M., Cooper, Christopher G.F., Aerts, Johannes M.F.G., Copeland, Diane P., Scheule, Ronald K., Cheng, Seng H., Marshall, John
Published in Molecular genetics and metabolism (01.04.2012)
Published in Molecular genetics and metabolism (01.04.2012)
Get full text
Journal Article
Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy
Marshall, John, McEachern, Kerry Anne, Chuang, Wei-Lien, Hutto, Elizabeth, Siegel, Craig S, Shayman, James A, Grabowski, Greg A, Scheule, Ronald K, Copeland, Diane P, Cheng, Seng H
Published in Journal of inherited metabolic disease (01.06.2010)
Published in Journal of inherited metabolic disease (01.06.2010)
Get full text
Journal Article
The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function
CHAI, Lilly, MCLAREN, Rajashree P, TEICHER, Beverly A, CARTER, Kara, CHENG, Seng H, LEONARD, John P, YIBIN XIANG, VASCONCELLES, Michael, GOLDBERG, Mark A, COPELAND, Diane P, KLINGER, Katherine W, LILLIE, James, BYRNE, Ann, MADDEN, Stephen L, JIANG, Yide A, CHUANG, Wei-Lien, YINYIN HUANG, DUFAULT, Michael R, PACHECO, Joshua, MADHIWALLA, Shruti, XIAOKUI ZHANG, ZHANG, Mindy
Published in International journal of oncology (01.03.2011)
Published in International journal of oncology (01.03.2011)
Get full text
Journal Article
112638 AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
COPELAND DIANE P, MARSHALL JOHN, BHARDWAJ RENU, SIEGEL CRAIG, CHENG SENG, WILLIS CHRIS, HARIANAWALA ABIZER, LIU HANLAN, SKELL JEFFREY, PALACE GERARD, KOCHLING JIANMEI, PETERSCHMITT JUDITH
Year of Publication 08.12.2022
Get full text
Year of Publication 08.12.2022
Patent
112638 AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
COPELAND DIANE P, MARSHALL JOHN, BHARDWAJ RENU, SIEGEL CRAIG, CHENG SENG, WILLIS CHRIS, HARIANAWALA ABIZER, LIU HANLAN, SKELL JEFFREY, PALACE GERARD, KOCHLING JIANMEI, PETERSCHMITT JUDITH
Year of Publication 05.02.2020
Get full text
Year of Publication 05.02.2020
Patent
A Glucosylceramide Synthase Inhibitor Prevents the Cytotoxic Effects of Shiga Toxin-2 on Human Renal Tubular Epithelial Cells
Silberstein, Claudia, Copeland, Diane P., Chiang, Wei-Lien, Repetto, Horacio A., Ibarra, Cristina
Published in Journal of epithelial biology & pharmacology (02.01.2009)
Published in Journal of epithelial biology & pharmacology (02.01.2009)
Get full text
Journal Article
112638 AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
COPELAND DIANE P, MARSHALL JOHN, BHARDWAJ RENU, SIEGEL CRAIG, CHENG SENG, WILLIS CHRIS, HARIANAWALA ABIZER, LIU HANLAN, SKELL JEFFREY, PALACE GERARD, KOCHLING JIANMEI, PETERSCHMITT JUDITH
Year of Publication 10.05.2018
Get full text
Year of Publication 10.05.2018
Patent
AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRAT AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
COPELAND DIANE P, MARSHALL JOHN, BHARDWAJ RENU, SIEGEL CRAIG, CHENG SENG, WILLIS CHRIS, HARIANAWALA ABIZER, LIU HANLAN, SKELL JEFFREY, PALACE GERARD, KOCHLING JIANMEI, PETERSCHMITT JUDITH
Year of Publication 09.11.2015
Get full text
Year of Publication 09.11.2015
Patent
AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRAT AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
COPELAND DIANE P, MARSHALL JOHN, BHARDWAJ RENU, SIEGEL CRAIG, CHENG SENG, WILLIS CHRIS, HARIANAWALA ABIZER, LIU HANLAN, SKELL JEFFREY, PALACE GERARD, KOCHLING JIANMEI, PETERSCHMITT JUDITH
Year of Publication 19.10.2012
Get full text
Year of Publication 19.10.2012
Patent
AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
LIU, HANLAN, WILLIS, CHRIS, BHARDWAJ, RENU, MARSHALL, JOHN, KOCHLING, JIANNEI, COPELAND, DIANE P, PALACE, GERARD, SKELL, JEFFREY, SIEGEL, CRAIG, PETERSCHMITT, JUDITH, HARIANAWALA, ABIZER, CHENG, SENG
Year of Publication 29.08.2022
Get full text
Year of Publication 29.08.2022
Patent
INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
PETERSCHMITT, Judith, SIEGEL, Craig, WILLIS, Chris, MARSHALL, John, HARIANAWALA, Abizer, LIU, Hanlan, CHENG, Seng, COPELAND, Diane P, BHARDWAJ, Renu, SKELL, Jeffrey, PALACE, Gerard, KOCHLING, Jianmei
Year of Publication 23.12.2021
Get full text
Year of Publication 23.12.2021
Patent
AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
LIU, HANLAN, BHARDWAJ, RENU, MARSHALL, JOHN, COPELAND, DIANE P, PALACE, GERARD, SKELL, JEFFREY, KOCHLING, JIANMEI, SIEGEL, CRAIG, PETERSCHMITT, JUDITH, HARIANAWALA, ABIZER, WILLIS, CHRISTOPHER, CHENG, SENG
Year of Publication 21.12.2021
Get full text
Year of Publication 21.12.2021
Patent
INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
PETERSCHMITT, Judith, SIEGEL, Craig, WILLIS, Chris, MARSHALL, John, HARIANAWALA, Abizer, LIU, Hanlan, CHENG, Seng, COPELAND, Diane P, BHARDWAJ, Renu, SKELL, Jeffrey, PALACE, Gerard, KOCHLING, Jianmei
Year of Publication 02.12.2021
Get full text
Year of Publication 02.12.2021
Patent
PHARMACEUTICAL COMPOSITION OF THE GLUCOSYLCERAMIDE SYNTHASE INHIBITOR ELIGLUSTAT FOR THE TREATMENT GAUCHER'S DISEASE COMPRISING ADJUSTING THE INDIVIDUAL THERAPEUTICAL DOSE TO THE P450 METABOLISM OF THE PATIENT
PETERSCHMITT, Judith, SIEGEL, Craig, WILLIS, Chris, MARSHALL, John, HARIANAWALA, Abizer, LIU, Hanlan, CHENG, Seng, COPELAND, Diane P, BHARDWAJ, Renu, SKELL, Jeffrey, PALACE, Gerard, KOCHLING, Jianmei
Year of Publication 20.10.2021
Get full text
Year of Publication 20.10.2021
Patent
PHARMACEUTICAL COMPOSITION OF THE GLUCOSYLCERAMIDE SYNTHASE INHIBITOR ELIGLUSTAT FOR THE TREATMENT OF GAUCHER'S DISEASE COMPRISING ADJUSTING THE INDIVIDUAL THERAPEUTICAL DOSE TO THE P450 METABOLISM OF THE PATIENT
LIU, HANLAN, WILLIS, CHRIS, BHARDWAJ, RENU, MARSHALL, JOHN, COPELAND, DIANE P, PALACE, GERARD, SKELL, JEFFREY, KOCHLING, JIANMEI, SIEGEL, CRAIG, PETERSCHMITT, JUDITH, HARIANAWALA, ABIZER, CHENG, SENG
Year of Publication 27.09.2021
Get full text
Year of Publication 27.09.2021
Patent
AN AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
LIU Hanlan, WILLIS Chris, PETERSCHMITT Judith, BHARDWAJ Renu, MARSHALL John, KOCHLING Jianmei, SIEGEL Craig, CHENG Seng, HARIANAWALA Abizer, COPELAND Diane P, PALACE Gerard, SKELL Jeffrey
Year of Publication 31.08.2021
Get full text
Year of Publication 31.08.2021
Patent