The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists
Rech, Jason C., Bhattacharya, Anindya, Branstetter, Bryan J., Love, Christopher J., Leenaerts, Joseph E., Cooymans, Ludwig P., Eckert, William A., Ao, Hong, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Lebsack, Alec D., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1 H -indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2 H -imidazo[4,5- c ]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus
Vendeville, Sandrine, Tahri, Abdellah, Hu, Lili, Demin, Samuel, Cooymans, Ludwig, Vos, Ann, Kwanten, Leen, Van den Berg, Joke, Battles, Michael B., McLellan, Jason S., Koul, Anil, Raboisson, Pierre, Roymans, Dirk, Jonckers, Tim H. M.
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors
Grosse, Sandrine, Cooymans, Ludwig, Embrechts, Werner, McGowan, David, Jacoby, Edgar, Stoops, Bart, Gupta, Kusum, Ackermann, Mark, Alnajjar, Sarhad, Guillemont, Jerome, Jin, Zhinan, Kesteleyn, Bart, Matcha, Kiran, Sriboonyapirat, Pun, Truong, Anh, Van Den Berg, Joke, Yu, Xiaodi, Herschke, Florence, Roymans, Dirk, Raboisson, Pierre, Rigaux, Peter, Jonckers, Tim H. M.
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Discovery of 3‑({5-Chloro-1-[3-(methylsulfonyl)propyl]‑1H‑indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro‑2H‑imidazo[4,5‑c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus
Vendeville, Sandrine, Tahri, Abdellah, Hu, Lili, Demin, Samuel, Cooymans, Ludwig, Vos, Ann, Kwanten, Leen, Van den Berg, Joke, Battles, Michael B, McLellan, Jason S, Koul, Anil, Raboisson, Pierre, Roymans, Dirk, Jonckers, Tim H. M
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region
McGowan, David C, Balemans, Wendy, Embrechts, Werner, Motte, Magali, Keown, Jeremy R, Buyck, Christophe, Corbera, Jordi, Funes, Mario, Moreno, Laura, Cooymans, Ludwig, Tahri, Abdellah, Eymard, Julien, Stoops, Bart, Strijbos, Rudy, Van den Berg, Joke, Fodor, Ervin, Grimes, Jonathan M, Koul, Anil, Jonckers, Tim H. M, Raboisson, Pierre, Guillemont, Jérôme
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Structure-Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors
Tran, Minh T, Grosse, Sandrine, Carbajo, Rodrigo J, Jacoby, Edgar, Yin, Yanting, Yu, Xiaodi, Martinez, Carol, Stoops, Bart, Cooymans, Ludwig, Hu, Lili, Lutter, Ferdinand H, Pieters, Serge, Tan, Eric, Alcázar, Jesus, Roymans, Dirk, van Vlijmen, Herman, Rigaux, Peter, Sharma, Sujata, Jonckers, Tim H M
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)p y rimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists
Rech, Jason C, Bhattacharya, Anindya, Branstetter, Bryan J, Love, Christopher J, Leenaerts, Joseph E, Cooymans, Ludwig P, Eckert, William A, Ao, Hong, Wang, Qi, Chaplan, Sandra R, Wickenden, Alan D, Lebsack, Alec D, Breitenbucher, JGuy
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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PIPERIDINE SUBSTITUTED PYRAZOLO[15-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS RSV
COOYMANS LUDWIG PAUL, VENDEVILLE SANDRINE MARIE HELENE, DEMIN SAMUEL DOMINIQUE, RABOISSON PIERRE JEAN MARIE BERNARD, HU LILI, JONCKERS TIM HUGO MARIA, TAHRI ABDELLAH
Year of Publication 07.08.2017
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Year of Publication 07.08.2017
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인플루엔자 바이러스 감염에서 사용하기 위한 복소환식 인돌
COOYMANS LUDWIG PAUL, MC GOWAN DAVID CRAIG, BUYCK CHRISTOPHE FRANCIS ROBERT NESTOR, EMBRECHTS WERNER CONSTANT JOHAN, RABOISSON PIERRE JEAN MARIE BERNARD, JONCKERS TIM HUGO MARIA, BALEMANS WENDY MIA ALBERT, GUILLEMONT JEROME EMILE GEORGES
Year of Publication 01.08.2018
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Year of Publication 01.08.2018
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RSV ANTIVIRAL COMPOUNDS
COOYMANS LUDWIG PAUL, VENDEVILLE SANDRINE MARIE HELENE, RABOISSON PIERRE JEAN MARIE BERNARD, HU LILI, DEMIN SAMUEEL DOMINIQUE, JONCKERS TIM HUGO MARIA, TAHRI ABDELLAH
Year of Publication 24.06.2015
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Year of Publication 24.06.2015
Patent