Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
Geller, Leore T., Barzily-Rokni, Michal, Danino, Tal, Jonas, Oliver H., Shental, Noam, Nejman, Deborah, Gavert, Nancy, Zwang, Yaara, Cooper, Zachary A., Shee, Kevin, Thaiss, Christoph A., Reuben, Alexandre, Livny, Jonathan, Avraham, Roi, Frederick, Dennie T., Ligorio, Matteo, Chatman, Kelly, Johnston, Stephen E., Mosher, Carrie M., Brandis, Alexander, Fuks, Garold, Gurbatri, Candice, Gopalakrishnan, Vancheswaran, Kim, Michael, Hurd, Mark W., Katz, Matthew, Fleming, Jason, Maitra, Anirban, Smith, David A., Skalak, Matt, Bu, Jeffrey, Michaud, Monia, Trauger, Sunia A., Barshack, Iris, Golan, Talia, Sandbank, Judith, Flaherty, Keith T., Mandinova, Anna, Garrett, Wendy S., Thayer, Sarah P., Ferrone, Cristina R., Huttenhower, Curtis, Bhatia, Sangeeta N., Gevers, Dirk, Wargo, Jennifer A., Golub, Todd R., Straussman, Ravid
Published in Science (American Association for the Advancement of Science) (15.09.2017)
Published in Science (American Association for the Advancement of Science) (15.09.2017)
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Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
Roh, Whijae, Chen, Pei-Ling, Reuben, Alexandre, Spencer, Christine N, Prieto, Peter A, Miller, John P, Gopalakrishnan, Vancheswaran, Wang, Feng, Cooper, Zachary A, Reddy, Sangeetha M, Gumbs, Curtis, Little, Latasha, Chang, Qing, Chen, Wei-Shen, Wani, Khalida, De Macedo, Mariana Petaccia, Chen, Eveline, Austin-Breneman, Jacob L, Jiang, Hong, Roszik, Jason, Tetzlaff, Michael T, Davies, Michael A, Gershenwald, Jeffrey E, Tawbi, Hussein, Lazar, Alexander J, Hwu, Patrick, Hwu, Wen-Jen, Diab, Adi, Glitza, Isabella C, Patel, Sapna P, Woodman, Scott E, Amaria, Rodabe N, Prieto, Victor G, Hu, Jianhua, Sharma, Padmanee, Allison, James P, Chin, Lynda, Zhang, Jianhua, Wargo, Jennifer A, Futreal, P Andrew
Published in Science translational medicine (01.03.2017)
Published in Science translational medicine (01.03.2017)
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Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy
Smith, Michael P., Brunton, Holly, Rowling, Emily J., Ferguson, Jennifer, Arozarena, Imanol, Miskolczi, Zsofia, Lee, Jessica L., Girotti, Maria R., Marais, Richard, Levesque, Mitchell P., Dummer, Reinhard, Frederick, Dennie T., Flaherty, Keith T., Cooper, Zachary A., Wargo, Jennifer A., Wellbrock, Claudia
Published in Cancer cell (14.03.2016)
Published in Cancer cell (14.03.2016)
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The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
Lin, Luping, Sabnis, Amit J, Chan, Elton, Olivas, Victor, Cade, Lindsay, Pazarentzos, Evangelos, Asthana, Saurabh, Neel, Dana, Yan, Jenny Jiacheng, Lu, Xinyuan, Pham, Luu, Wang, Mingxue M, Karachaliou, Niki, Cao, Maria Gonzalez, Manzano, Jose Luis, Ramirez, Jose Luis, Torres, Jose Miguel Sanchez, Buttitta, Fiamma, Rudin, Charles M, Collisson, Eric A, Algazi, Alain, Robinson, Eric, Osman, Iman, Muñoz-Couselo, Eva, Cortes, Javier, Frederick, Dennie T, Cooper, Zachary A, McMahon, Martin, Marchetti, Antonio, Rosell, Rafael, Flaherty, Keith T, Wargo, Jennifer A, Bivona, Trever G
Published in Nature genetics (01.03.2015)
Published in Nature genetics (01.03.2015)
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Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation
Singh, Manisha, Khong, Hiep, Dai, Zhimin, Huang, Xue-Fei, Wargo, Jennifer A, Cooper, Zachary A, Vasilakos, John P, Hwu, Patrick, Overwijk, Willem W
Published in The Journal of immunology (1950) (01.11.2014)
Published in The Journal of immunology (1950) (01.11.2014)
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A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors
Konieczkowski, David J, Johannessen, Cory M, Abudayyeh, Omar, Kim, Jong Wook, Cooper, Zachary A, Piris, Adriano, Frederick, Dennie T, Barzily-Rokni, Michal, Straussman, Ravid, Haq, Rizwan, Fisher, David E, Mesirov, Jill P, Hahn, William C, Flaherty, Keith T, Wargo, Jennifer A, Tamayo, Pablo, Garraway, Levi A
Published in Cancer discovery (01.07.2014)
Published in Cancer discovery (01.07.2014)
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Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
KHALILI, Jahan S, SHUJUAN LIU, MIN ZHANG, JOSEPH, Richard W, BERNATCHEZ, Chantale, EKMEKCIOGLU, Suhendan, GRIMM, Elizabeth, RADVANYI, Laszlo G, DAVIS, Richard E, DAVIES, Michael A, WARGO, Jennifer A, HWU, Patrick, RODRIGUEZ-CRUZ, Tania G, LIZEE, Gregory, WHITTINGTON, Mayra, WARDELL, Seth, CHENGWEN LIU, MINYING ZHANG, COOPER, Zachary A, FREDERICK, Dennie T, YUFENG LI
Published in Clinical cancer research (01.10.2012)
Published in Clinical cancer research (01.10.2012)
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Elucidating distinct roles for NF1 in melanomagenesis
Maertens, Ophélia, Johnson, Bryan, Hollstein, Pablo, Frederick, Dennie T, Cooper, Zachary A, Messiaen, Ludwine, Bronson, Roderick T, McMahon, Martin, Granter, Scott, Flaherty, Keith, Wargo, Jennifer A, Marais, Richard, Cichowski, Karen
Published in Cancer discovery (01.03.2013)
Published in Cancer discovery (01.03.2013)
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An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition
Young, Helen L, Rowling, Emily J, Bugatti, Mattia, Giurisato, Emanuele, Luheshi, Nadia, Arozarena, Imanol, Acosta, Juan-Carlos, Kamarashev, Jivko, Frederick, Dennie T, Cooper, Zachary A, Reuben, Alexandre, Gil, Jesus, Flaherty, Keith T, Wargo, Jennifer A, Vermi, William, Smith, Michael P, Wellbrock, Claudia, Hurlstone, Adam
Published in The Journal of experimental medicine (05.06.2017)
Published in The Journal of experimental medicine (05.06.2017)
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Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2
O'Connell, Michael P, Marchbank, Katie, Webster, Marie R, Valiga, Alexander A, Kaur, Amanpreet, Vultur, Adina, Li, Ling, Herlyn, Meenhard, Villanueva, Jessie, Liu, Qin, Yin, Xiangfan, Widura, Sandy, Nelson, Janelle, Ruiz, Nivia, Camilli, Tura C, Indig, Fred E, Flaherty, Keith T, Wargo, Jennifer A, Frederick, Dennie T, Cooper, Zachary A, Nair, Suresh, Amaravadi, Ravi K, Schuchter, Lynn M, Karakousis, Giorgos C, Xu, Wei, Xu, Xiaowei, Weeraratna, Ashani T
Published in Cancer discovery (01.12.2013)
Published in Cancer discovery (01.12.2013)
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Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma
Qin, Yong, Roszik, Jason, Chattopadhyay, Chandrani, Hashimoto, Yuuri, Liu, Chengwen, Cooper, Zachary A, Wargo, Jennifer A, Hwu, Patrick, Ekmekcioglu, Suhendan, Grimm, Elizabeth A
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC
Tu, Eric, McGlinchey, Kelly, Wang, Jixin, Martin, Philip, Ching, Steven Lk, Floc'h, Nicolas, Kurasawa, James, Starrett, Jacqueline H, Lazdun, Yelena, Wetzel, Leslie, Nuttall, Barrett, Ng, Felicia Sl, Coffman, Karen T, Smith, Paul D, Politi, Katerina, Cooper, Zachary A, Streicher, Katie
Published in JCI insight (08.02.2022)
Published in JCI insight (08.02.2022)
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Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment
Friedman, Adam A, Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Baniya, Subash, Cooper, Zachary A, Piris, Adriano, Hargreaves, Leeza, Igras, Vivien, Frederick, Dennie T, Lawrence, Donald P, Haber, Daniel A, Flaherty, Keith T, Wargo, Jennifer A, Ramaswamy, Sridhar, Benes, Cyril H, Fisher, David E
Published in PloS one (13.10.2015)
Published in PloS one (13.10.2015)
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Toll-like Receptor Agonists and Febrile Range Hyperthermia Synergize to Induce Heat Shock Protein 70 Expression and Extracellular Release
Gupta, Aditi, Cooper, Zachary A., Tulapurkar, Mohan E., Potla, Ratnakar, Maity, Tapan, Hasday, Jeffrey D., Singh, Ishwar S.
Published in The Journal of biological chemistry (25.01.2013)
Published in The Journal of biological chemistry (25.01.2013)
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Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation
Kim, Hyungsoo, Frederick, Dennie T., Levesque, Mitchell P., Cooper, Zachary A., Feng, Yongmei, Krepler, Clemens, Brill, Laurence, Samuels, Yardena, Hayward, Nicholas K., Perlina, Ally, Piris, Adriano, Zhang, Tongwu, Halaban, Ruth, Herlyn, Meenhard M., Brown, Kevin M., Wargo, Jennifer A., Dummer, Reinhard, Flaherty, Keith T., Ronai, Ze’ev A.
Published in Cell reports (Cambridge) (09.06.2015)
Published in Cell reports (Cambridge) (09.06.2015)
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Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure
Smith, Michael P, Rowling, Emily J, Miskolczi, Zsofia, Ferguson, Jennifer, Spoerri, Loredana, Haass, Nikolas K, Sloss, Olivia, McEntegart, Sophie, Arozarena, Imanol, von Kriegsheim, Alex, Rodriguez, Javier, Brunton, Holly, Kmarashev, Jivko, Levesque, Mitchell P, Dummer, Reinhard, Frederick, Dennie T, Andrews, Miles C, Cooper, Zachary A, Flaherty, Keith T, Wargo, Jennifer A, Wellbrock, Claudia
Published in EMBO molecular medicine (01.08.2017)
Published in EMBO molecular medicine (01.08.2017)
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Histone Deacetylase 6 (HDAC6) Deacetylates Survivin for Its Nuclear Export in Breast Cancer
Riolo, Matthew T., Cooper, Zachary A., Holloway, Michael P., Cheng, Yan, Bianchi, Cesario, Yakirevich, Evgeny, Ma, Li, Chin, Y. Eugene, Altura, Rachel A.
Published in The Journal of biological chemistry (30.03.2012)
Published in The Journal of biological chemistry (30.03.2012)
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The Combiome Hypothesis: Selecting Optimal Treatment for Cancer Patients
Hirsch, Fred R., Walker, Jill, Higgs, Brandon W., Cooper, Zachary A., Raja, Rajiv G., Wistuba, Ignacio I.
Published in Clinical lung cancer (01.01.2022)
Published in Clinical lung cancer (01.01.2022)
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Comparative immunologic characterization of autoimmune giant cell myocarditis with ipilimumab
Reuben, Alexandre, Petaccia de Macedo, Mariana, McQuade, Jennifer, Joon, Aron, Ren, Zhiyong, Calderone, Tiffany, Conner, Brandy, Wani, Khalida, Cooper, Zachary A, Tawbi, Hussein, Tetzlaff, Michael T, Padera, Robert F, Durand, Jean-Bernard, Lazar, Alexander J, Wargo, Jennifer A, Davies, Michael A
Published in Oncoimmunology (01.01.2017)
Published in Oncoimmunology (01.01.2017)
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