CDK7 inhibitors as anticancer drugs
Sava, Georgina P., Fan, Hailing, Coombes, R. Charles, Buluwela, Lakjaya, Ali, Simak
Published in Cancer and metastasis reviews (01.09.2020)
Published in Cancer and metastasis reviews (01.09.2020)
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Journal Article
Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts
Shaw, Jacqueline A, Guttery, David S, Hills, Allison, Fernandez-Garcia, Daniel, Page, Karen, Rosales, Brenda M, Goddard, Kate S, Hastings, Robert K, Luo, Jinli, Ogle, Olivia, Woodley, Laura, Ali, Simak, Stebbing, Justin, Coombes, R Charles
Published in Clinical cancer research (01.01.2017)
Published in Clinical cancer research (01.01.2017)
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Journal Article
Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers
Penders, Jelle, Nagelkerke, Anika, Cunnane, Eoghan M, Pedersen, Simon V, Pence, Isaac J, Coombes, R. Charles, Stevens, Molly M
Published in ACS nano (23.11.2021)
Published in ACS nano (23.11.2021)
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Journal Article
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
Hong, Sung Pil, Chan, Thalia E., Lombardo, Ylenia, Corleone, Giacomo, Rotmensz, Nicole, Bravaccini, Sara, Rocca, Andrea, Pruneri, Giancarlo, McEwen, Kirsten R., Coombes, R. Charles, Barozzi, Iros, Magnani, Luca
Published in Nature communications (02.09.2019)
Published in Nature communications (02.09.2019)
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Journal Article
ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P, Bondke, Alexander, Slafer, Brian W, Kroll, Sebastian H B, Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O, Buluwela, Laki, Fuchter, Matthew J, Barrett, Anthony G M, Coombes, R Charles, Ali, Simak
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Journal Article
Triple-negative breast cancer: therapeutic options
Cleator, Susan, Dr, Heller, Wolfgang, MD, Coombes, R Charles, Prof
Published in The lancet oncology (01.03.2007)
Published in The lancet oncology (01.03.2007)
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Journal Article
A framework for the development of effective anti-metastatic agents
Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D., Ritchie, James W. A.
Published in Nature reviews. Clinical oncology (01.03.2019)
Published in Nature reviews. Clinical oncology (01.03.2019)
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Journal Article
Conference Proceeding
FOXA1 is a determinant of drug resistance in breast cancer cells
Kumar, Uttom, Ardasheva, Anastasia, Mahmud, Zimam, Coombes, R. Charles, Yagüe, Ernesto
Published in Breast cancer research and treatment (01.04.2021)
Published in Breast cancer research and treatment (01.04.2021)
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Journal Article
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
Peck, Barrie, Chen, Chun-Yuan, Ho, Ka-Kei, Di Fruscia, Paolo, Myatt, Stephen S, Coombes, R Charles, Fuchter, Matthew J, Hsiao, Chwan-Deng, Lam, Eric W-F
Published in Molecular cancer therapeutics (01.04.2010)
Published in Molecular cancer therapeutics (01.04.2010)
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Journal Article
Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer
Fernandez-Garcia, Daniel, Hills, Allison, Page, Karen, Hastings, Robert K, Toghill, Bradley, Goddard, Kate S, Ion, Charlotte, Ogle, Olivia, Boydell, Anna Rita, Gleason, Kelly, Rutherford, Mark, Lim, Adrian, Guttery, David S, Coombes, R Charles, Shaw, Jacqueline A
Published in Breast cancer research : BCR (19.12.2019)
Published in Breast cancer research : BCR (19.12.2019)
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Journal Article
Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer
Guttery, David S, Page, Karen, Hills, Allison, Woodley, Laura, Marchese, Stephanie D, Rghebi, Basma, Hastings, Robert K, Luo, Jinli, Pringle, J Howard, Stebbing, Justin, Coombes, R Charles, Ali, Simak, Shaw, Jacqueline A
Published in Clinical chemistry (Baltimore, Md.) (01.07.2015)
Published in Clinical chemistry (Baltimore, Md.) (01.07.2015)
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Journal Article
Influence of plasma processing on recovery and analysis of circulating nucleic acids
Page, Karen, Guttery, David S, Zahra, Nathalie, Primrose, Lindsay, Elshaw, Shona R, Pringle, J Howard, Blighe, Kevin, Marchese, Stephanie D, Hills, Allison, Woodley, Laura, Stebbing, Justin, Coombes, R Charles, Shaw, Jacqueline A
Published in PloS one (18.10.2013)
Published in PloS one (18.10.2013)
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Journal Article
Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis
Zhang, Yanjun, Clausmeyer, Jan, Babakinejad, Babak, López Córdoba, Ainara, Ali, Tayyibah, Shevchuk, Andrew, Takahashi, Yasufumi, Novak, Pavel, Edwards, Christopher, Lab, Max, Gopal, Sahana, Chiappini, Ciro, Anand, Uma, Magnani, Luca, Coombes, R. Charles, Gorelik, Julia, Matsue, Tomokazu, Schuhmann, Wolfgang, Klenerman, David, Sviderskaya, Elena V, Korchev, Yuri
Published in ACS nano (22.03.2016)
Published in ACS nano (22.03.2016)
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Journal Article
Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer
Fernandez-Garcia, Daniel, Nteliopoulos, Georgios, Hastings, Robert K., Rushton, Amelia, Page, Karen, Allsopp, Rebecca C., Ambasager, Bana, Gleason, Kelly, Guttery, David S., Ali, Simak, Charles Coombes, R., Shaw, Jacqueline A.
Published in British journal of cancer (09.11.2022)
Published in British journal of cancer (09.11.2022)
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Journal Article
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
Periyasamy, Manikandan, Singh, Anup K, Gemma, Carolina, Kranjec, Christian, Farzan, Raed, Leach, Damien A, Navaratnam, Naveenan, Pálinkás, Hajnalka L, Vértessy, Beata G, Fenton, Tim R, Doorbar, John, Fuller-Pace, Frances, Meek, David W, Coombes, R Charles, Buluwela, Laki, Ali, Simak
Published in Nucleic acids research (02.11.2017)
Published in Nucleic acids research (02.11.2017)
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Journal Article
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion
Nguyen, Van T. M., Barozzi, Iros, Faronato, Monica, Lombardo, Ylenia, Steel, Jennifer H., Patel, Naina, Darbre, Philippa, Castellano, Leandro, Győrffy, Balázs, Woodley, Laura, Meira, Alba, Patten, Darren K., Vircillo, Valentina, Periyasamy, Manikandan, Ali, Simak, Frige, Gianmaria, Minucci, Saverio, Coombes, R. Charles, Magnani, Luca
Published in Nature communications (27.11.2015)
Published in Nature communications (27.11.2015)
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Journal Article
estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response
Castellano, Leandro, Giamas, Georgios, Jacob, Jimmy, Coombes, R. Charles, Lucchesi, Walter, Thiruchelvam, Paul, Barton, Geraint, Jiao, Long R, Wait, Robin, Waxman, Jonathan, Hannon, Gregory J, Stebbing, Justin
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
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Journal Article
APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer
Periyasamy, Manikandan, Patel, Hetal, Lai, Chun-Fui, Nguyen, Van T.M., Nevedomskaya, Ekaterina, Harrod, Alison, Russell, Roslin, Remenyi, Judit, Ochocka, Anna Maria, Thomas, Ross S., Fuller-Pace, Frances, Győrffy, Balázs, Caldas, Carlos, Navaratnam, Naveenan, Carroll, Jason S., Zwart, Wilbert, Coombes, R. Charles, Magnani, Luca, Buluwela, Laki, Ali, Simak
Published in Cell reports (Cambridge) (06.10.2015)
Published in Cell reports (Cambridge) (06.10.2015)
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Journal Article
Genomic analysis of circulating cell-free DNA infers breast cancer dormancy
Shaw, Jacqueline A, Page, Karen, Blighe, Kevin, Hava, Natasha, Guttery, David, Ward, Becky, Brown, James, Ruangpratheep, Chetana, Stebbing, Justin, Payne, Rachel, Palmieri, Carlo, Cleator, Suzy, Walker, Rosemary A, Coombes, R Charles
Published in Genome research (01.02.2012)
Published in Genome research (01.02.2012)
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A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p.H1047R breast cancer mutation
Kalofonou, Melpomeni, Malpartida-Cardenas, Kenny, Alexandrou, George, Rodriguez-Manzano, Jesus, Yu, Ling-Shan, Miscourides, Nicholas, Allsopp, Rebecca, Gleason, Kelly L. T., Goddard, Katie, Fernandez-Garcia, Daniel, Page, Karen, Georgiou, Pantelis, Ali, Simak, Coombes, R. Charles, Shaw, Jacqueline, Toumazou, Christofer
Published in Scientific reports (12.03.2020)
Published in Scientific reports (12.03.2020)
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