CDK7 inhibitors as anticancer drugs
Sava, Georgina P., Fan, Hailing, Coombes, R. Charles, Buluwela, Lakjaya, Ali, Simak
Published in Cancer and metastasis reviews (01.09.2020)
Published in Cancer and metastasis reviews (01.09.2020)
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Journal Article
Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts
Shaw, Jacqueline A, Guttery, David S, Hills, Allison, Fernandez-Garcia, Daniel, Page, Karen, Rosales, Brenda M, Goddard, Kate S, Hastings, Robert K, Luo, Jinli, Ogle, Olivia, Woodley, Laura, Ali, Simak, Stebbing, Justin, Coombes, R Charles
Published in Clinical cancer research (01.01.2017)
Published in Clinical cancer research (01.01.2017)
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Journal Article
ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P, Bondke, Alexander, Slafer, Brian W, Kroll, Sebastian H B, Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O, Buluwela, Laki, Fuchter, Matthew J, Barrett, Anthony G M, Coombes, R Charles, Ali, Simak
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Journal Article
A Review of Circulating Tumour Cell Enrichment Technologies
Rushton, Amelia J, Nteliopoulos, Georgios, Shaw, Jacqueline A, Coombes, R Charles
Published in Cancers (26.02.2021)
Published in Cancers (26.02.2021)
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Journal Article
Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers
Penders, Jelle, Nagelkerke, Anika, Cunnane, Eoghan M, Pedersen, Simon V, Pence, Isaac J, Coombes, R. Charles, Stevens, Molly M
Published in ACS nano (23.11.2021)
Published in ACS nano (23.11.2021)
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Journal Article
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
Hong, Sung Pil, Chan, Thalia E, Lombardo, Ylenia, Corleone, Giacomo, Rotmensz, Nicole, Bravaccini, Sara, Rocca, Andrea, Pruneri, Giancarlo, McEwen, Kirsten R, Coombes, R Charles, Barozzi, Iros, Magnani, Luca
Published in Nature communications (02.09.2019)
Published in Nature communications (02.09.2019)
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Journal Article
ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942
Sava, Georgina P, Fan, Hailing, Fisher, Rosemary A, Lusvarghi, Sabrina, Pancholi, Sunil, Ambudkar, Suresh V, Martin, Lesley-Ann, Charles Coombes, R, Buluwela, Lakjaya, Ali, Simak
Published in Oncogene (16.01.2020)
Published in Oncogene (16.01.2020)
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Journal Article
A framework for the development of effective anti-metastatic agents
Anderson, Robin L, Balasas, Theo, Callaghan, Juliana, Coombes, R Charles, Evans, Jeff, Hall, Jacqueline A, Kinrade, Sally, Jones, David, Jones, Paul S, Jones, Rob, Marshall, John F, Panico, Maria Beatrice, Shaw, Jacqui A, Steeg, Patricia S, Sullivan, Mark, Tong, Warwick, Westwell, Andrew D, Ritchie, James W A
Published in Nature reviews. Clinical oncology (01.03.2019)
Published in Nature reviews. Clinical oncology (01.03.2019)
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Journal Article
Conference Proceeding
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
Peck, Barrie, Chen, Chun-Yuan, Ho, Ka-Kei, Di Fruscia, Paolo, Myatt, Stephen S, Coombes, R Charles, Fuchter, Matthew J, Hsiao, Chwan-Deng, Lam, Eric W-F
Published in Molecular cancer therapeutics (01.04.2010)
Published in Molecular cancer therapeutics (01.04.2010)
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Journal Article
Triple-negative breast cancer: therapeutic options
Cleator, Susan, Dr, Heller, Wolfgang, MD, Coombes, R Charles, Prof
Published in The lancet oncology (01.03.2007)
Published in The lancet oncology (01.03.2007)
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Journal Article
FOXA1 is a determinant of drug resistance in breast cancer cells
Kumar, Uttom, Ardasheva, Anastasia, Mahmud, Zimam, Coombes, R. Charles, Yagüe, Ernesto
Published in Breast cancer research and treatment (01.04.2021)
Published in Breast cancer research and treatment (01.04.2021)
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Journal Article
Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer
Fernandez-Garcia, Daniel, Hills, Allison, Page, Karen, Hastings, Robert K, Toghill, Bradley, Goddard, Kate S, Ion, Charlotte, Ogle, Olivia, Boydell, Anna Rita, Gleason, Kelly, Rutherford, Mark, Lim, Adrian, Guttery, David S, Coombes, R Charles, Shaw, Jacqueline A
Published in Breast cancer research : BCR (19.12.2019)
Published in Breast cancer research : BCR (19.12.2019)
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Journal Article
The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment
Monteiro, L J, Khongkow, P, Kongsema, M, Morris, J R, Man, C, Weekes, D, Koo, C-Y, Gomes, A R, Pinto, P H, Varghese, V, Kenny, L M, Charles Coombes, R, Freire, R, Medema, R H, Lam, E W-F
Published in Oncogene (26.09.2013)
Published in Oncogene (26.09.2013)
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Journal Article
Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study
Coombes, R Charles, Angelou, Christina, Al-Khalili, Zamzam, Hart, William, Francescatti, Darius, Wright, Nicholas, Ellis, Ian, Green, Andrew, Rakha, Emad, Shousha, Sami, Amrania, Hemmel, Phillips, Chris C., Palmieri, Carlo
Published in Breast cancer research and treatment (01.06.2024)
Published in Breast cancer research and treatment (01.06.2024)
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Journal Article
Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer
Fernandez-Garcia, Daniel, Nteliopoulos, Georgios, Hastings, Robert K, Rushton, Amelia, Page, Karen, Allsopp, Rebecca C, Ambasager, Bana, Gleason, Kelly, Guttery, David S, Ali, Simak, Charles Coombes, R, Shaw, Jacqueline A
Published in British journal of cancer (09.11.2022)
Published in British journal of cancer (09.11.2022)
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Journal Article
Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer
Guttery, David S, Page, Karen, Hills, Allison, Woodley, Laura, Marchese, Stephanie D, Rghebi, Basma, Hastings, Robert K, Luo, Jinli, Pringle, J Howard, Stebbing, Justin, Coombes, R Charles, Ali, Simak, Shaw, Jacqueline A
Published in Clinical chemistry (Baltimore, Md.) (01.07.2015)
Published in Clinical chemistry (Baltimore, Md.) (01.07.2015)
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Journal Article
Meta-Analysis of Breast Cancer Outcomes in Adjuvant Trials of Aromatase Inhibitors Versus Tamoxifen
DOWSETT, Mitch, CUZICK, Jack, COOMBES, Charles, SNOWDON, Claire, GNANT, Michael, JAKESZ, Raimund, KAUFMANN, Manfred, BOCCARDO, Francesco, GODWIN, Jon, DAVIES, Christina, PETO, Richard, INGLE, Jim, COATES, Alan, FORBES, John, BLISS, Judith, BUYSE, Marc, BAUM, Michael, BUZDAR, Aman, COLLEONI, Marco
Published in Journal of clinical oncology (20.01.2010)
Published in Journal of clinical oncology (20.01.2010)
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Journal Article
A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer
Braun, Stephan, Vogl, Florian D, Naume, Bjørn, Janni, Wolfgang, Osborne, Michael P, Coombes, R. Charles, Schlimok, Günter, Diel, Ingo J, Gerber, Bernd, Gebauer, Gerhard, Pierga, Jean-Yves, Marth, Christian, Oruzio, Daniel, Wiedswang, Gro, Solomayer, Erich-Franz, Kundt, Günther, Strobl, Barbara, Fehm, Tanja, Wong, George Y.C, Bliss, Judith, Vincent-Salomon, Anne, Pantel, Klaus
Published in The New England journal of medicine (25.08.2005)
Published in The New England journal of medicine (25.08.2005)
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Journal Article
Isoflurane, a Commonly Used Volatile Anesthetic, Enhances Renal Cancer Growth and Malignant Potential via the Hypoxia-inducible Factor Cellular Signaling Pathway In Vitro
Benzonana, Laura L., Perry, Nicholas J. S., Watts, Helena R., Yang, Bob, Perry, Iain A., Coombes, Charles, Takata, Masao, Ma, Daqing
Published in Anesthesiology (Philadelphia) (01.09.2013)
Published in Anesthesiology (Philadelphia) (01.09.2013)
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