Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
Lange, Jos H. M, Coolen, Hein K. A. C, van der Neut, Martina A. W, Borst, Alice J. M, Stork, Bob, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Lange, Jos H. M, van Stuivenberg, Herman H, Coolen, Hein K. A. C, Adolfs, Tiny J. P, McCreary, Andrew C, Keizer, Hiskias G, Wals, Henri C, Veerman, Willem, Borst, Alice J. M, de Looff, Wouter, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1H-indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition
Smid, Pieter, Coolen, Hein K. A. C, Keizer, Hiskias G, van Hes, Rolf, de Moes, Jan-Peter, den Hartog, Arnold P, Stork, Bob, Plekkenpol, Rob H, Niemann, Leonarda C, Stroomer, Cees N. J, Tulp, Martin Th. M, van Stuivenberg, Herman H, McCreary, Andrew C, Hesselink, Mayke B, Herremans, Arnoud H. J, Kruse, Chris G
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Journal Article
Principal Component Analysis Differentiates the Receptor Binding Profiles of Three Antipsychotic Drug Candidates from Current Antipsychotic Drugs
Lange, Jos H. M, Reinders, Jan-Hendrik, Tolboom, Jeroen T. B. M, Glennon, Jeffrey C, Coolen, Hein K. A. C, Kruse, Chris G
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Journal Article
7-Azaindole derivatives as potential partial nicotinic agonists
Stoit, Axel R., den Hartog, Arnold P., Mons, Harry, van Schaik, Sjoerd, Barkhuijsen, Nynke, Stroomer, Cees, Coolen, Hein K.A.C., Reinders, Jan Hendrik, Adolfs, Tiny J.P., van der Neut, Martina, Keizer, Hiskias, Kruse, Chris G.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Lange, Jos H. M, Coolen, Hein K. A. C, van Stuivenberg, Herman H, Dijksman, Jessica A. R, Herremans, Arnoud H. J, Ronken, Eric, Keizer, Hiskias G, Tipker, Koos, McCreary, Andrew C, Veerman, Willem, Wals, Henri C, Stork, Bob, Verveer, Peter C, den Hartog, Arnold P, de Jong, Natasja M. J, Adolfs, Tiny J. P, Hoogendoorn, Jan, Kruse, Chris G
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Journal Article
Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity
LANGE, Jos H. M, VAN STUIVENBERG, Herman H, VEERMAN, Willem, WALS, Henri C, STORK, Bob, COOLEN, Hein K. A. C, MCCREARY, Andrew C, ADOLFS, Tiny J. P, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Journal Article
Substrate Selective Catalysis by Rhodium Metallohosts
Coolen, Hein K. A. C, Meeuwis, Johannes A. M, van Leeuwen, Piet W. M. N, Nolte, Roeland J. M
Published in Journal of the American Chemical Society (01.12.1995)
Published in Journal of the American Chemical Society (01.12.1995)
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Journal Article
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P(5) receptor agonist chemotype
Stoit, Axel R., Lange, Jos H. M., Coolen, Hein K. A. C., Rensink, Annemieke, van den Hoogenband, Adri, den Hartog, Arnold P., van Schaik, Sjoerd, Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Journal Article
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P5 receptor agonist chemotype
Stoit, Axel R., Lange, Jos H.M., Coolen, Hein K.A.C., Rensink, Annemieke, van den Hoogenband, Adri, den Hartog, Arnold P., van Schaik, Sjoerd, Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Journal Article
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P 5 receptor agonist chemotype
Stoit, Axel R, Lange, Jos H M, Coolen, Hein K A C, Rensink, Annemieke, van den Hoogenband, Adri, den Hartog, Arnold P, van Schaik, Sjoerd, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Journal Article
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB 1 Receptor Antagonism
Lange, Jos H. M., Coolen, Hein K. A. C., van der Neut, Martina A. W., Borst, Alice J. M., Stork, Bob, Verveer, Peter C., Kruse, Chris G.
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
Get full text
Journal Article
Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB 1 Cannabinoid Receptor Antagonists
Lange, Jos H. M., van Stuivenberg, Herman H., Coolen, Hein K. A. C., Adolfs, Tiny J. P., McCreary, Andrew C., Keizer, Hiskias G., Wals, Henri C., Veerman, Willem, Borst, Alice J. M., de Looff, Wouter, Verveer, Peter C., Kruse, Chris G.
Published in Journal of medicinal chemistry (01.03.2005)
Published in Journal of medicinal chemistry (01.03.2005)
Get full text
Journal Article
Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1 H -indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D 2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition
Smid, Pieter, Coolen, Hein K. A. C., Keizer, Hiskias G., van Hes, Rolf, de Moes, Jan-Peter, den Hartog, Arnold P., Stork, Bob, Plekkenpol, Rob H., Niemann, Leonarda C., Stroomer, Cees N. J., Tulp, Martin Th. M., van Stuivenberg, Herman H., McCreary, Andrew C., Hesselink, Mayke B., Herremans, Arnoud H. J., Kruse, Chris G.
Published in Journal of medicinal chemistry (01.11.2005)
Published in Journal of medicinal chemistry (01.11.2005)
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Journal Article
Spiro-cyclic amine derivatives as S1P modulators
Stoit, Axel, Iwema Bakker, Wouter I, Coolen, Hein K. A. C, Hobson, Adrian, Leflemme, Nicolas J.-L. D, van Dongen, Maria J. P
Year of Publication 30.08.2022
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Year of Publication 30.08.2022
Patent
Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists
Lange, Jos H M, Coolen, Hein K A C, van Stuivenberg, Herman H, Dijksman, Jessica A R, Herremans, Arnoud H J, Ronken, Eric, Keizer, Hiskias G, Tipker, Koos, McCreary, Andrew C, Veerman, Willem, Wals, Henri C, Stork, Bob, Verveer, Peter C, den Hartog, Arnold P, de Jong, Natasja M J, Adolfs, Tiny J P, Hoogendoorn, Jan, Kruse, Chris G
Published in Journal of medicinal chemistry (29.01.2004)
Get full text
Published in Journal of medicinal chemistry (29.01.2004)
Journal Article
Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB 1 Cannabinoid Receptor Antagonists
Lange, Jos H. M., Coolen, Hein K. A. C., van Stuivenberg, Herman H., Dijksman, Jessica A. R., Herremans, Arnoud H. J., Ronken, Eric, Keizer, Hiskias G., Tipker, Koos, McCreary, Andrew C., Veerman, Willem, Wals, Henri C., Stork, Bob, Verveer, Peter C., den Hartog, Arnold P., de Jong, Natasja M. J., Adolfs, Tiny J. P., Hoogendoorn, Jan, Kruse, Chris G.
Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
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Journal Article
Fused heterocyclic derivatives as S1P modulators
Smid, Pieter, den Hartog, Jacobus A. J, Iwema Bakker, Wouter I, Coolen, Hein K. A. C, Hobson, Adrian, Sliedregt, Leonardus A. J. M, van Dongen, Maria J. P
Year of Publication 10.11.2020
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Year of Publication 10.11.2020
Patent
Spiro-cyclic amine derivatives as S1P modulators
Stoit, Axel, Iwema Bakker, Wouter I, Coolen, Hein K. A. C, Hobson, Adrian, Leflemme, Nicolas J.-L. D, van Dongen, Maria J. P
Year of Publication 20.10.2020
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Year of Publication 20.10.2020
Patent