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Revascularization in the rabbit hindlimb: dissociation between capillary sprouting and arteriogenesis
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Discovery and evaluation of potent P-1 aryl heterocycle-based thrombin inhibitors
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Published in Journal of medicinal chemistry (03.06.2004)
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Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines
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Published in Journal of medicinal chemistry (13.02.2003)
Published in Journal of medicinal chemistry (13.02.2003)
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9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors
Stauffer, Kenneth J, Williams, Peter D, Selnick, Harold G, Nantermet, Philippe G, Newton, Christina L, Homnick, Carl F, Zrada, Matthew M, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Pietrak, Beth L, Lyle, Elizabeth A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Wallace, Audrey A, Sitko, Gary R, Cook, Jacquelyn J, Holahan, Marie A, Stranieri-Michener, Maria, Leonard, Yvonne M, Lynch, Joseph J, McMasters, Daniel R, Yan, Youwei
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists
WOOD, Michael R, SCHIRRIPA, Kathy M, CHANG, Raymond S. L, HOLAHAN, Marie A, COOK, Jacquelynn J, LEMAIRE, Wei, MOSSER, Scott D, BEDNAR, Rodney A, CUYUE TANG, PRUEKSARITANONT, Thomayant, WALLACE, Audrey A, QIN MEI, KIM, June J, JIAN YU, BOHN, Dennis L, CLAYTON, Frank C, ADARAYN, Emily D, SITKO, Gary R, LEONARD, Yvonne M, FREIDINGER, Roger M, PETTIBONE, Douglas J, BOCK, Mark G, KUDUK, Scott D, CHANG, Ronald K, DI MARCO, Christina N, DIPARDO, Robert M, WAN, Bang-Lin, MURPHY, Kathy L, RANSOM, Richard W
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Demonstration of enhanced endogenous fibrinolysis in thrombin activatable fibrinolysis inhibitor-deficient mice
Mao, Shi-Shan, Holahan, Marie A, Bailey, Carolyn, Wu, Guoxin, Colussi, Dennis, Carroll, Steven S, Cook, Jacquelynn J
Published in Blood coagulation & fibrinolysis (01.09.2005)
Published in Blood coagulation & fibrinolysis (01.09.2005)
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Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics
Barrow, James C, Nantermet, Philippe G, Stauffer, Shaun R, Ngo, Phung L, Steinbeiser, Melissa A, Mao, Shi-Shan, Carroll, Steven S, Bailey, Carolyn, Colussi, Dennis, Bosserman, Michelle, Burlein, Christine, Cook, Jacquelynn J, Sitko, Gary, Tiller, Philip R, Miller-Stein, Cynthia M, Rose, Mark, McMasters, Daniel R, Vacca, Joseph P, Selnick, Harold G
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position
Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P
Published in Journal of medicinal chemistry (13.08.1998)
Published in Journal of medicinal chemistry (13.08.1998)
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Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates
Sanderson, Philip E. J, Lyle, Terry A, Cutrona, Kellie J, Dyer, Dona L, Dorsey, Bruce D, McDonough, Colleen M, Naylor-Olsen, Adel M, Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J, Cooper, Carolyn M, Gardell, Stephen J, Hare, Timothy R, Krueger, Julie A, Lewis, S. Dale, Lin, Jiunn H, Lucas, Bobby J, Lyle, Elizabeth A, Lynch, Joseph J, Stranieri, Maria T, Vastag, Kari, Yan, Youwei, Shafer, Jules A, Vacca, Joseph P
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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Fibrinogen Receptor Antagonist-Induced Thrombocytopenia in Chimpanzee and Rhesus Monkey Associated With Preexisting Drug-Dependent Antibodies to Platelet Glycoprotein IIb/IIIa
Bednar, Bohumil, Cook, Jacquelynn J., Holahan, Marie A., Cunningham, Michael E., Jumes, Patricia A., Bednar, Rodney A., Hartman, George D., Gould, Robert J.
Published in Blood (15.07.1999)
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Determination of potato carboxypeptidase inhibitor in African Green Monkey plasma using 96-well SPE and LC–MS/MS
Rose, Mark J., Fernandez-Metzler, Carmen, Johns, Brett A., Sitko, Gary R., Cook, Jacquelynn J., Yergey, James
Published in Journal of pharmaceutical and biomedical analysis (15.07.2005)
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Non-peptide glycoprotein IIb/IIIa antagonists .2. Design and in vivo evaluation of 3,4-dihydro-1(1H)-isoquinolinone-based antagonists and ethyl ester prodrugs
Hutchinson, JH, Cook, JJ, Brashear, KM, Breslin, MJ, Glass, JD, Gould, RJ, Halczenko, W, Holahan, MA, Lynch, RJ, Sitko, GR, Stranieri, MT, Hartman, GD
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Enhanced hindlimb collateralization induced by acidic fibroblast growth factor is dependent upon femoral artery extraction
HERSHEY, James C, CORCORAN, Halea A, BASKIN, Elizabeth P, GILBERTO, David B, XIANZHI MAO, THOMAS, Kenneth A, COOK, Jacquelynn J
Published in Cardiovascular research (01.10.2003)
Published in Cardiovascular research (01.10.2003)
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Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support
Brady, Stephen F, Stauffer, Kenneth J, Lumma, William C, Smith, Graham M, Ramjit, Harri G, Lewis, S. Dale, Lucas, Bobby J, Gardell, Steven J, Lyle, Elizabeth A, Appleby, Sandra D, Cook, Jacquelynn J, Holahan, Marie A, Stranieri, Maria T, Lynch, Joseph J, Lin, Jiunn H, Chen, I.-Wu, Vastag, Kari, Naylor-Olsen, Adel M, Vacca, Joseph P
Published in Journal of medicinal chemistry (29.01.1998)
Published in Journal of medicinal chemistry (29.01.1998)
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Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation
Egbertson, Melissa S, Cook, Jacquelynn J, Bednar, Bohumil, Prugh, John D, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Hartman, George D, Homnick, Carl F, Holahan, Marie A, Libby, Laura A, Lynch, Joseph J, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Vassallo, Laura M
Published in Journal of medicinal chemistry (01.07.1999)
Published in Journal of medicinal chemistry (01.07.1999)
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An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey
COOK, J. J, SITKO, G. R, BEDNAR, B, CONDRA, C, MELLOTT, M. J, DONG-MEI FENG, NUTT, R. F, SHAFER, J. A, GOULD, R. J, CONNOLLY, T. M
Published in Circulation (New York, N.Y.) (15.06.1995)
Published in Circulation (New York, N.Y.) (15.06.1995)
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L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor
Sanderson, Philip E.J., Cutrona, Kellie J., Dorsey, Bruce D., Dyer, Dona L., McDonough, Colleen M., Naylor-Olsen, Adel M., Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J., Gardell, Stephen J., Krueger, Julie A., Lewis, S.Dale, Lin, Jiunn H., Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Stranieri, Maria T., Vastag, Kari, Shafer, Jules A., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
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