Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR
Houck, Scott A., Ren, Hong Yu, Madden, Victoria J., Bonner, Jacob N., Conlin, Michael P., Janovick, Jo Ann, Conn, P. Michael, Cyr, Douglas M.
Published in Molecular cell (10.04.2014)
Published in Molecular cell (10.04.2014)
Get full text
Journal Article
Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy
Jo Ann Janovick, Stewart, M. David, Jacob, Darla, Martin, L. D., Deng, Jian Min, Stewart, C. Allison, Wang, Ying, Cornea, Anda, Chavali, Lakshmi, Lopez, Suhujey, Mitalipov, Shoukhrat, Kang, Eunju, Lee, Hyo-Sang, Manna, Pulak R., Stocco, Douglas M., Behringer, Richard R., Conn, P. Michael
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
Get full text
Journal Article
Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice
Wang, Huizhen, Larson, Melissa, Jablonka-Shariff, Albina, Pearl, Christopher A., Miller, William L., Conn, P. Michael, Boime, Irving, Kumar, T. Rajendra
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2014)
Get full text
Journal Article
Salt bridge integrates GPCR activation with protein trafficking
Janovick, Jo Ann, Conn, P. Michael
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
Get full text
Journal Article
The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane
Re, Michelle, Pampillo, Macarena, Savard, Martin, Dubuc, Céléna, McArdle, Craig A, Millar, Robert P, Conn, P Michael, Gobeil, Jr, Fernand, Bhattacharya, Moshmi, Babwah, Andy V
Published in PloS one (08.07.2010)
Published in PloS one (08.07.2010)
Get full text
Journal Article
Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity
Janovick, Jo Ann, Pogozheva, Irina D, Mosberg, Henry I, Cornea, Anda, Conn, P. Michael
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2012)
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2012)
Get full text
Journal Article
Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231
Aguilar-Rojas, Arturo, Huerta-Reyes, Maira, Maya-Núñez, Guadalupe, Arechavaleta-Velásco, Fabián, Conn, P Michael, Ulloa-Aguirre, Alfredo, Valdés, Jesús
Published in BMC cancer (23.11.2012)
Published in BMC cancer (23.11.2012)
Get full text
Journal Article
Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor
Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T, Altman, Michael D, Rush, Thomas S, Cornea, Anda, Conn, P. Michael
Published in Molecular endocrinology (Baltimore, Md.) (01.02.2009)
Published in Molecular endocrinology (Baltimore, Md.) (01.02.2009)
Get full text
Journal Article
Mice Harboring Gnrhr E90K, a Mutation that Causes Protein Misfolding and Hypogonadotropic Hypogonadism in Humans, Exhibit Testis Size Reduction and Ovulation Failure
Stewart, M. David, Deng, Jian Ming, Stewart, C. Allison, Mullen, Rachael D, Wang, Ying, Lopez, Suhujey, Serna, M. Katalina, Huang, Cheng-Chiu, Janovick, Jo Ann, Pask, Andrew J, Schwartz, Robert J, Conn, P. Michael, Behringer, Richard R
Published in Molecular endocrinology (Baltimore, Md.) (01.11.2012)
Published in Molecular endocrinology (Baltimore, Md.) (01.11.2012)
Get full text
Journal Article
Pharmacological Profile of a New, Potent, and Long-Acting Gonadotropin-Releasing Hormone Antagonist: Degarelix
Broqua, Pierre, Riviere, Pierre J-M, Conn, P Michael, Rivier, Jean E, Aubert, Michel L, Junien, Jean-Louis
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Get full text
Journal Article
Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor
Janovick, Jo Ann, Goulet, Mark, Bush, Eugene, Greer, Jonathan, Wettlaufer, David G, Conn, P Michael
Published in The Journal of pharmacology and experimental therapeutics (01.05.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2003)
Get full text
Journal Article